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Short-term Effects of Cadmium Exposure on Blood Pressure and Vascular Function in Wistar Rats
Chronic cadmium exposure is known to be associated with vascular changes and increased blood pressure, but its short-term effects on the...
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In vitro cadmium exposure induces structural damage and endothelial dysfunction in female rat aorta
Cadmium is a heavy metal that is widespread in the environment and has been described as a metalloestrogen and a cardiovascular risk factor....
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Cessation Restores Blood Pressure Levels and Endothelial Function Affected by Cadmium Exposure on Rats
Chronic cadmium exposure produces high blood pressure and endothelial damage; however, it is not known whether these effects could be reversed by...
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Effects of Nephrectomy on the Electrical Field Stimulation-Evoked Changes in Tone of Arteries from the Normotensive and Spontaneously Hypertensive Rats
AbstractThe effects of nephrectomy on the electrical field stimulation-evoked changes in tone of Wistar–Kyoto (WKY) and spontaneously...
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Effect of Doxorubicin on the Reactivity of Rat Mesenteric Arteries
AbstractDoxorubicin is widely used as an antitumor drug, but it has a negative effect on the cardiovascular system. While special attention has...
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Reactivity of Mesenteric Arteries in the Development of Metabolic Syndrome in Rats Fed on a High-Fat Diet
AbstractHigh-fat diet (HFD) can lead to the development of metabolic syndrome (MS). However, the issue of the mechanisms underlying...
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α1-Adrenergic Stimulation Increases Platelet Adhesion to Endothelial Cells Mediated by TRPC6
Stimulation of a1-adrenergicAdrenergic nervous systemNervous system is increased during systemic inflammationInflammation and other pathological...
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ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation
Moderate autophagy can remove damaged proteins and organelles. In some inflammatory diseases, autophagy plays a protective role by inhibiting the...
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Epulmonary Arterial Hypertension Attenuates Vasoconstrictor Responses Caused by Activation of Alpha-1-Adrenoreceptors in the Systemic Circulation
AbstractPulmonary arterial hypertension (PAH) accompanied by an arterial pressure increase in the pulmonary circulation, remodeling of...
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TNIP3 protects against pathological cardiac hypertrophy by stabilizing STAT1
Pathological cardiac hypertrophy is one of the major risk factors of heart failure and other cardiovascular diseases. However, the mechanisms...
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Endothelium-Independent Anti-Contractile Effect of Rat Aorta Perivascular Adipose Tissue at Control and Metabolic Disorders Induced by the Cafe Diet
AbstractThe use of high-calorie nutrition can lead to morpho-functional changes of the vascular bed that have clinical importance, however, the...
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Effect of Nephrectomy on Arterial Reactivity in Spontaneously Hypertensive Rats
AbstractThe effects of 5/6 nephrectomy on contractile and dilatory properties of the superior mesenteric artery (SMA) and internal carotid artery...
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UGCG modulates heart hypertrophy through B4GalT5-mediated mitochondrial oxidative stress and the ERK signaling pathway
Mechanical pressure overload and other stimuli often contribute to heart hypertrophy, a significant factor in the induction of heart failure. The...
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The MEF2A transcription factor interactome in cardiomyocytes
Transcriptional regulators encoded by the
M yocyteE nhancerF actor2 (MEF2) gene family play a fundamental role in cardiac development, homeostasis...
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α1-Adrenergic Receptors Control the Activity of Sinoatrial Node by Modulating Transmembrane Transport of Chloride Anions
AbstractNorepinephrine (NE), which is released by sympathetic nerve endings, causes an increase in the frequency of spontaneous action potentials in...
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Functional State of Mesenteric Arteries and Vessels of the Skin Microcirculatory Bed in Rats with Experimental Kidney Dysfunction
AbstractChronic kidney disease is accompanied by cardiovascular complications, including endothelial dysfunction, arterial hypertension, and...
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Longitudinal detection of gait alterations associated with hypertension-induced cerebral microhemorrhages in mice: predictive role of stride length and stride time asymmetry and increased gait entropy
Cerebral microhemorrhages (CMHs) are of paramount importance as they not only signify underlying vascular pathology but also have profound...
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The Influence of Probenecid on the Proarrhythmic Effects of the Activation of α-1-adrenoceptor in the Atrioventricular Node of the Rat Heart
AbstractThe cardiac tissue contains not only beta-type adrenergic receptors (ARs) but also alpha-type ARs (α-ARs). Both types of ARs play a...
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Poly (ADP-ribose) polymerases 16 triggers pathological cardiac hypertrophy via activating IRE1α–sXBP1–GATA4 pathway
BackgroundPressure overload-induced pathological cardiac hypertrophy is an independent predecessor of heart failure (HF), which remains the leading...
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Early Functional Changes in Rat Arteries and Microcirculatory Vessels while Modeling Metabolic Syndrome
AbstractEarly changes in the cardiovascular system of young Wistar rats were studied in modeling metabolic syndrome by a fructose load. It was found...
