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Analysis of Peroxisome Biogenesis by Phos-Tag SDS-PAGE
Phos-tag, a selective phosphate-binding molecule, and Phos-tag-based methodologies have been developed to investigate the phosphoproteome. In various...
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Peroxisome biogenesis and inter-organelle communication: an indispensable role for Pex11 and Pex30 family proteins in yeast
Peroxisomes are highly dynamic organelles present in most eukaryotic cells. They also play an important role in human health and the optimum...
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Applying CRISPR-Cas9 Genome Editing to Study Genes Involved in Peroxisome Biogenesis or Peroxisomal Functions
The development and application of the CRISPR-Cas9 technology for genome editing of mammalian cells have opened up a wealth of possibilities for...
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Quantitative subcellular reconstruction reveals a lipid mediated inter-organelle biogenesis network
The structures and functions of organelles in cells depend on each other but have not been systematically explored. We established stable knockout...
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High-content image screening to identify chemical modulators for peroxisome and ferroptosis
BackgroundThe peroxisome is a dynamic organelle with variety in number, size, shape, and activity in different cell types and physiological states....
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ZNF281 inhibits mitochondrial biogenesis to facilitate metastasis of hepatocellular carcinoma
Zinc finger protein 281 (ZNF281) has been shown to promote tumor progression. However, the underlying mechanism remains to be further elucidated. In...
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Loss of functional peroxisomes leads to increased mitochondrial biogenesis and reduced autophagy that preserve mitochondrial function
Peroxisomes are essential for mitochondrial health, as the absence of peroxisomes leads to altered mitochondria. However, it is unclear whether the...
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Characterization of the Multiple Domains of Pex30 Involved in Subcellular Localization of the Protein and Regulation of Peroxisome Number
Pex30 is a peroxisomal protein whose role in peroxisome biogenesis via the endoplasmic reticulum has been established. It is a 58 KDa multi-domain...
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FGF19 increases mitochondrial biogenesis and fusion in chondrocytes via the AMPKα-p38/MAPK pathway
Fibroblast growth factor 19 (FGF19) is recognized to play an essential role in cartilage development and physiology, and has emerged as a potential...
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Therapeutic effects of genistein in experimentally induced ulcerative colitis in rats via affecting mitochondrial biogenesis
Ulcerative colitis (UC) is an inflammatory bowel disease that affects the mucosa of the colon, resulting in severe inflammation and ulcers. Genistein...
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Pex30 undergoes phosphorylation and regulates peroxisome number in Saccharomyces cerevisiae
Pex30 is a dysferlin domain-containing protein whose role in peroxisome biogenesis has been studied by several research groups. Notably, recent...
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Infliximab Ameliorates Methotrexate-Induced Nephrotoxicity in Experimental Rat Model: Impact on Oxidative Stress, Mitochondrial Biogenesis, Apoptotic and Autophagic Machineries
Accumulating data confirms that Methotrexate (MTX), a well-known immunosuppressive and anticancer drug, causes nephrotoxicity. Infliximab (INF), the...
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Dietary cysteine and methionine promote peroxisome elevation and fat loss by induction of CG33474 expression in Drosophila adipose tissue
The high-protein diet (HPD) has emerged as a potent dietary approach to curb obesity. Peroxisome, a highly malleable organelle, adapts to nutritional...
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CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis
BackgroundCementoblasts on the tooth-root surface are responsible for cementum formation (cementogenesis) and sensitive to Porphyromonas gingivalis ...
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The nexus between peroxisome abundance and chronological ageing in Saccharomyces cerevisiae
Ageing is characterized by changes in several cellular processes, with dysregulation of peroxisome function being one of them. Interestingly, the...
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Andrographolide attenuated MCT-induced HSOS via regulating NRF2-initiated mitochondrial biogenesis and antioxidant response
Hepatic sinusoidal obstruction syndrome (HSOS) is a death-dealing liver disease with a fatality rate of up to 67%. In the study present, we explored...
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Lipid overload-induced RTN3 activation leads to cardiac dysfunction by promoting lipid droplet biogenesis
Lipid droplet (LD) accumulation is a notable feature of obesity-induced cardiomyopathy, while underlying mechanism remains poorly understood. Here we...
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PGC-1α affects skeletal muscle and adipose tissue development by regulating mitochondrial biogenesis
The discovery and interpretation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) protein in mitochondrial biogenesis,...
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PGC-1a mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration
Neurodegenerative disorders are characterized by the progressive loss of structure and function of neurons, often including the death of the neuron....
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TRPA1 promotes the maturation of embryonic stem cell-derived cardiomyocytes by regulating mitochondrial biogenesis and dynamics
BackgroundCardiomyocytes derived from pluripotent stem cells (PSC-CMs) have been widely accepted as a promising cell source for cardiac drug...
