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1. Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions

   The mitochondrial permeability transition (mPT) describes a Ca ²⁺ -dependent and cyclophilin D (CypD)-facilitated increase of inner mitochondrial...

   Paolo Bernardi, Christoph Gerle, ... Alexander A. Soukas in Cell Death & Differentiation

   Article Open access 17 July 2023
   

2. Nano-flow cytometry unveils mitochondrial permeability transition process and multi-pathway cell death induction for cancer therapy

   Mitochondrial permeability transition (mPT)-mediated mitochondrial dysfunction plays a pivotal role in various human diseases. However, the intricate...

   Liyun Su, **gyi Xu, ... **aomei Yan in Cell Death Discovery

   Article Open access 15 April 2024
   

3. Molecular mechanisms and consequences of mitochondrial permeability transition

   Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of low molecular weight solutes (molecular weight up to...

   Massimo Bonora, Carlotta Giorgi, Paolo Pinton in Nature Reviews Molecular Cell Biology

   Article 08 December 2021
   

4. Translocator Protein Is Involved in the Induction and Regulation of Mitochondrial Permeability Transition Pore Opening in C6 Glioma Cells

   Abstract

   Translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor (PBR), is a 18-kDa protein localized in the outer...

   Yu. L. Baburina, L. D. Sotnikova, O. V. Krestinina in Cell and Tissue Biology

   Article 27 April 2023
   

5. EFHD1 promotes osteosarcoma proliferation and drug resistance by inhibiting the opening of the mitochondrial membrane permeability transition pore (mPTP) by binding to ANT3

   Chemoresistance is the main obstacle in the clinical treatment of osteosarcoma (OS). In this study, we investigated the role of EF-hand...

   **n Shen, Mengjun Ma, ... Huiyong Shen in Cellular and Molecular Life Sciences

   Article Open access 25 May 2024
   

6. The opening of mitochondrial permeability transition pore (mPTP) and the inhibition of electron transfer chain (ETC) induce mitophagy in wheat roots under waterlogging stress

   Mitochondria are crucial for the regulation of intracellular energy metabolism, biosynthesis, and cell survival. And studies have demonstrated the...

   Yueli Wang, Hailong Ye, ... Zhuqing Zhou in Protoplasma

   Article 06 February 2023
   

7. Mitochondrial Permeability Transition in Stem Cells, Development, and Disease

   The mitochondrial permeability transition (mPT) is a process that permits rapid exchange of small molecules across the inner mitochondrial membrane...

   Sandeep P. Dumbali, Pamela L. Wenzel in Cell Biology and Translational Medicine, Volume 18

   Chapter 2022
   

8. Nonspecific Permeability Pore (mPTP) in Plant Mitochondria and Its Role in Cell Death

   Abstract

   Current concepts are reviewed concerning the structure, regulatory mechanisms, and the functional role of nonspecific permeability pore (also...

   P. A. Butsanets, N. A. Shugaeva, A. G. Shugaev in Russian Journal of Plant Physiology

   Article 21 July 2023
   

9. Mitochondrial DNA release via the mitochondrial permeability transition pore activates the cGAS-STING pathway, exacerbating inflammation in acute Kawasaki disease

   Background

   Kawasaki disease (KD) is an immune vasculitis of unknown origin, characterized by transient inflammation. The activation of the cGAS-STING...

   Ke Wei, Tao Chen, ... Jianmei Zhao in Cell Communication and Signaling

   Article Open access 13 June 2024
   

10. Rotenone Decreases Ischemia-Induced Injury by Inhibiting Mitochondrial Permeability Transition: A Study in Brain

    Mitochondria participate in many physiological and pathological processes in the cells, including cellular energy supply, regulation of calcium...

    Ramune Morkuniene, Evelina Rekuviene, Dalia M. Kopustinskiene in Mitochondria

    Protocol 2022
    

11. M2 macrophage-secreted exosomes promote metastasis and increase vascular permeability in hepatocellular carcinoma

    Background

    Metastasis is a key feature of malignant tumors and significantly contributes to their high mortality, particularly in hepatocellular...

    Yiwei Lu, Guoyong Han, ... **dao Wu in Cell Communication and Signaling

    Article Open access 30 October 2023
    

12. Downhill running induced DNA damage enhances mitochondrial membrane permeability by facilitating ER-mitochondria signaling

    To observe whether downhill running can lead to DNA damage in skeletal muscle cells and changes in mitochondrial membrane permeability and to explore...

    Jun** Li, Binting Zhao, ... Ruiyuan Wang in Journal of Muscle Research and Cell Motility

    Article 09 November 2022
    

13. Cell Membrane State, Permeability, and Elasticity Assessment for Single Cells and Cell Ensembles

    The phase state and especially phase transitions of synthetic lipid membranes are known to drastically modulate mechanical membrane properties like...

    Nicolas Färber, Simon V. Neidinger, Christoph Westerhausen in Cell Viability Assays

    Protocol 2023
    

14. Simultaneous Acquisition of Mitochondrial Calcium Retention Capacity and Swelling to Measure Permeability Transition Sensitivity

    The loss of mitochondrial cristae integrity and mitochondrial swelling are hallmarks of multiple forms of necrotic cell death. One of the most...

    Arielys M. Mendoza, Jason Karch in Mitochondria

    Protocol 2022
    

15. Trans-Resveratrol Decreases Membrane Water Permeability: A Study of Cholesterol-Dependent Interactions

    Resveratrol (RSV), a biologically active plant phenol, has been extensively investigated for cancer prevention and treatment due to its ability to...

    Jasmin Ceja-Vega, Escarlin Perez, ... Sunghee Lee in The Journal of Membrane Biology

    Article 24 June 2022
    

16. Monosodium Glutamate Induces Cytotoxicity in Rat Liver via Mitochondrial Permeability Transition Pore Opening

    Monosodium glutamate (MSG) is a major food additive used as a flavor enhancer. A lot of controversies have been generated over the use of MSG. The...

    Adeola Oluwakemi Olowofolahan, Oluwatobi Andrew Adeosun, Olufunso Olabode Olorunsogo in Cell Biochemistry and Biophysics

    Article 23 September 2020
    

17. Ca²⁺-Dependent Regulation of Proton Permeability of the Inner Membrane in the Mitochondria of Lupine Cotyledons

    Abstract

    The effect of exogenous Ca ²⁺ on respiration, generation of membrane potential, change in volume, and proton permeability of the inner...

    A. G. Shugaev, P. A. Butsanets, N. A. Shugaeva in Russian Journal of Plant Physiology

    Article 22 June 2023
    

18. PAI-1 regulates AT2-mediated re-alveolarization and ion permeability

    Background

    Acute lung injury is characterized by overwhelmingly elevated PAI-1 in both lung edema fluid and the circulating system. The role of...

    Gibran Ali, Mo Zhang, ... Hong-Long Ji in Stem Cell Research & Therapy

    Article Open access 27 July 2023
    

19. Molecular and Cellular Aspects of the Endothelial–Mesenchymal Transition in Cardiovascular Diseases

    Abstract

    Endothelial cells (ECs), which form the inner surface of the blood vessels, contact the blood, withstand mechanical pressure, and demonstrate...

    E. A. Strelnikova, R. E. Kalinin, ... N. D. Mzhavanadze in Molecular Biology

    Article 08 August 2023
    

20. Involvement of the Mitochondrial Ca²⁺-Independent Phospholipase iPLA2 in the Induction of Mitochondrial Permeability Transition Pore by Long-Chain Acylcarnitines

    Abstract

    It is known that activated derivatives of long-chain fatty acids acylcarnitines (LCAC) are considered the most toxic, which, along with...

    N. I. Fedotcheva, E. V. Grishina, V. V. Dynnik in Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology

    Article 10 December 2023