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1. Non-coding RNAs Function in Periodontal Ligament Stem Cells

   Non-coding RNA has many types which has rich functions and plays an important role in the study of basic molecular mechanisms. Many non-coding RNA...

   Wei Zhai, Jie Gao, ... Yuerong Xu in Stem Cell Reviews and Reports

   Article 07 June 2024
   

2. TRPC expression in human periodontal ligament cells and the periodontal tissue of periodontitis mice: a preliminary study

   Background

   Transient receptor potential canonical (TRPC) channels are non-selective cationic channels with permeability to Ca ²⁺ and Na ⁺ . Despite...

   Aeryun Kim, Ae Ri Kim, ... Eun‑Jung Bak in Laboratory Animal Research

   Article Open access 01 September 2023
   

3. Residual periodontal ligament in the extraction socket promotes the dentin regeneration potential of DPSCs in the rabbit jaw

   Background

   Because of the low regeneration efficiency and unclear underlying molecular mechanism, tooth regeneration applications are limited. In this...

   Bin Luo, Yu Luo, ... Qingsong Jiang in Stem Cell Research & Therapy

   Article Open access 20 March 2023
   

4. Cardamonin decreases inflammatory mediator expression in IL-1β-stimulated human periodontal ligament cells

   Background

   Cardamonin is classified as a natural chalcone, and has been reported to possess various bioactive effects. However, there have been...

   Risa Okamoto, Yoshitaka Hosokawa, ... Keiichi Hosaka in Molecular Biology Reports

   Article 28 January 2024
   

5. Mechanical force induces mitophagy-mediated anaerobic oxidation in periodontal ligament stem cells

   Background

   The preference for glucose oxidative mode has crucial impacts on various physiological activities, including determining stem cell fate....

   Zijie Zhang, Shuyue Cui, ... Fulan Wei in Cellular & Molecular Biology Letters

   Article Open access 21 July 2023
   

6. MicroRNA-671-5p regulates the inflammatory response of periodontal ligament stem cells via the DUSP8/p38 MAPK pathway

   Background

   MicroRNAs are differentially expressed in periodontitis tissues. They are involved in cellular responses to inflammation and can be used as...

   Shifen Wang, Yajiao Ren, ... Yao Wang in Molecular Biology Reports

   Article 10 May 2024
   

7. Evaluation on the efficacy of processed hydrated and dehydrated amnion chorion membrane on the proliferation of periodontal ligament fibroblasts

   The purpose of the present study was to process and assess the effect of hydrated amnion chorion membrane and dehydrated amnion chorion membrane on...

   Ayesha Khan, Shaila V. Kothiwale in Cell and Tissue Banking

   Article 25 February 2023
   

8. Effects of vitamin A in promoting proliferation and osteogenic differentiation of human periodontal ligament cells

   Human periodontal ligament cells (hPDLCs) are known as ideal seed cells for the regeneration of periodontal tissues. Several factors (i.e., vitamin D ₃ ...

   **g Wang, Zhaobao Li in In Vitro Cellular & Developmental Biology - Animal

   Article 01 February 2023
   

9. ANGPTL4 regulates the osteogenic differentiation of periodontal ligament stem cells

   The molecular mechanism of mechanical force regulating the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) has not been...

   Lingli Xu, Chengze Wang, ... Guoli Yang in Functional & Integrative Genomics

   Article 13 July 2022
   

10. Licochalcone B, a natural anti-inflammatory agent, inhibits the inflammatory response and oxidative stress of periodontal ligament cells in periodontitis

    Background

    Periodontitis is a multi-microbial infection characterized by a destructive inflammatory process that affects periodontal tissues. The...

    Zhen Du, **angling Liao, Qichao Kang in Molecular & Cellular Toxicology

    Article 07 April 2024
    

11. Regulation of proliferation and apoptosis of aging periodontal ligament cells by autophagy-related gene 7

    Background

    Human periodontal ligament cells (hPDLCs) can be applied in periodontal regeneration engineering to repair the tissue defects related to...

    Yiheng Wang, **nyi Li, ... **angyi He in Molecular Biology Reports

    Article 15 June 2023
    

12. Fluid shear stress promotes periodontal ligament cells proliferation via p38-AMOT-YAP

    Periodontal ligament (PDL) cells are a promising tool for periodontal regeneration therapy. Achieving a sufficient number of PDL cells is essential...

    Qiusheng Shi, Lisha Zheng, ... Yubo Fan in Cellular and Molecular Life Sciences

    Article 16 October 2022
    

13. Insulin-like growth factor binding protein 5 accelerate the senescence of periodontal ligament stem cells

    Evidences have showed stem cell mediated tissue regeneration is a promising method for the treatment of periodontitis. Insulin-like growth factor...

    Le Li, Haiyan Wang, ... Yu Cao in Cell and Tissue Banking

    Article 08 August 2022
    

14. Periodontal ligament stem cells as a promising therapeutic target for neural damage

    Background

    The damaged neuronal cells of adult mammalian lack the regenerative ability to replace the neuronal connections. Periodontal ligament stem...

    Fariba Mohebichamkhorami, Roya Fattahi, ... Hakimeh Zali in Stem Cell Research & Therapy

    Article Open access 21 June 2022
    

15. Transdifferentiation of periodontal ligament stem cells into acinar cells using an indirect co-culture system

    Serous Acinar Cells (ACs) are mature and functional secretory epithelial cells that develop and complete through other stem cells at the end of the...

    Nafiseh Sheykhbahaei, Fatemeh Bayramzadeh, Maryam Koopaie in Cell and Tissue Banking

    Article 18 August 2022
    

16. mTOR is involved in LRP5-induced osteogenic differentiation of normal and aged periodontal ligament stem cells in vitro

    Periodontal ligament stem cells (PDLSCs) plays an important role in tissue engineering. As the age increased, the cell viability and osteogenic...

    Ke Yu, Chengze Wang, ... Ying Wang in Journal of Molecular Histology

    Article 24 August 2022
    

17. LRP6/filamentous-actin signaling facilitates osteogenic commitment in mechanically induced periodontal ligament stem cells

    Background

    Mechanotransduction mechanisms whereby periodontal ligament stem cells (PDLSCs) translate mechanical stress into biochemical signals and...

    Jixiao Wang, Huiqi Yang, ... Fulan Wei in Cellular & Molecular Biology Letters

    Article Open access 24 January 2023
    

18. Lipopolysaccharide induces oxidative stress and inhibits osteogenic differentiation in periodontal ligament stem cells through downregulating Nrf2

    Background

    Periodontitis, a common inflammatory disease in adults, causes the loss of alveolar bone, eventually leading to tooth loss. The inhibition...

    Yue Chen, Awuti Gulinuer, ** Zhao in Molecular & Cellular Toxicology

    Article 10 June 2022
    

19. Low concentrations of tumor necrosis factor-alpha promote human periodontal ligament stem cells osteogenic differentiation by activation of autophagy via inhibition of AKT/mTOR pathway

    Background

    Tumor necrosis factor-alpha (TNF-α) is one of the crucial inflammatory factors in alveolar bone metabolism during the process of...

    Qi Yu**, Luan Yijun, Wang Limei in Molecular Biology Reports

    Article 01 February 2023
    

20. Establishment of Down’s syndrome periodontal ligament cells by transfection with SV40T-Ag and hTERT

    Down’s syndrome is one of the most common human congenital genetic diseases and affected patients have increased risk of periodontal disease. To...

    Takeyoshi Asakawa, Atsushi Yamada, ... Takahiro Funatsu in Human Cell

    Article Open access 29 September 2021