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Multifunctional Peptide Biointerfaces
In creating useful devices for biomedical and other applications that come into contact with biological fluids, it is of great interest to mimic the...
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M13 phage grafted with peptide motifs as a tool to detect amyloid-β oligomers in brain tissue
Oligomeric clusters of amyloid-β (Aβ) are one of the major biomarkers for Alzheimer’s disease (AD). However, proficient methods to detect...
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cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers
The canonical BRG/BRM-associated factor (cBAF) complex is essential for chromatin opening at enhancers in mammalian cells. However, the nature of the...
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Antimicrobial Peptide Nanomaterials
Antimicrobial peptides exist throughout nature and are produced by multicellular organisms as a defence mechanism against pathogenic microbes....
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Molecular engineering of antimicrobial peptides: microbial targets, peptide motifs and translation opportunities
The global public health threat of antimicrobial resistance has led the scientific community to highly engage into research on alternative strategies...
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The MAMP Peptide Patterns of Bacterial Flagellins and Their Interaction with Plant Receptors: Bioinformatic and Coevolutionary Aspects
AbstractConserved motifs (peptide patterns) determining the elicitor properties of plant-pathogenic bacteria were identified in the amino acid...
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HSP70-binding motifs function as protein quality control degrons
Protein quality control (PQC) degrons are short protein segments that target misfolded proteins for proteasomal degradation, and thus protect cells...
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Peptide Nanostructured Materials as Drug Delivery Carriers
Peptides are ideal building blocks for biomaterials and nanostructures aimed at advanced drug delivery, with hydrogels playing an elected role for...
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α-Helix and Coiled-Coil Peptide Nanomaterials
Good synthetic access to peptide materials with controllable morphology holds great promise for medical applications, but also for the development of...
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β-Sheet and β-Hairpin Peptide Nanomaterials
Supramolecular peptide assemblies have emerged as promising next-generation nanomaterials for applications in medicine, tissue engineering, and...
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The Assembly-Line Enzymology of Nonribosomal Peptide Biosynthesis
Peptide natural products constitute a major class of secondary metabolites produced by microorganisms (mostly bacteria and fungi). In the past...
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Peptide Amphiphile Nanomaterials
Peptide amphiphiles (PAs) have emerged as an essential class of peptides, particularly in the bottom-up fabrication of innovative soft materials....
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Ultra-Short Peptide Nanomaterials
In the analysis of the materials formed by short peptides, we need to define what we mean by short, as the determination of “short peptide” has not...
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SaLT&PepPr is an interface-predicting language model for designing peptide-guided protein degraders
Protein-protein interactions (PPIs) are critical for biological processes and predicting the sites of these interactions is useful for both...
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HeteroTCR: A heterogeneous graph neural network-based method for predicting peptide-TCR interaction
Identifying interactions between T-cell receptors (TCRs) and immunogenic peptides holds profound implications across diverse research domains and...
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Structure-aware deep model for MHC-II peptide binding affinity prediction
The prediction of major histocompatibility complex (MHC)-peptide binding affinity is an important branch in immune bioinformatics, especially helpful...
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Connecting MHC-I-binding motifs with HLA alleles via deep learning
The selection of peptides presented by MHC molecules is crucial for antigen discovery. Previously, several predictors have shown impressive...
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Characterization of Peptide-Based Nanomaterials
In this chapter, we will thoroughly discuss characterization techniques used to elucidate the exact structure and define properties of peptide-based...
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Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor
The neuropeptide 26RFa, a member of the RF-amide peptide family, activates the pyroglutamylated RF-amide peptide receptor (QRFPR), a class A GPCR....
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Dishevelled2 activates WGEF via its interaction with a unique internal peptide motif of the GEF
The Wnt-planar cell polarity (Wnt-PCP) pathway is crucial in establishing cell polarity during development and tissue homoeostasis. This pathway is...
