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A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors
Pediatric patients with recurrent and refractory cancers are in most need for new treatments. This study developed patient-derived-xenograft (PDX)...
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Detection of Ferroptosis in Patient-Derived Tumor Models
Ferroptosis is a form of iron-dependent regulated cell death that is primarily caused by the accumulation of iron, lipid peroxidation, and subsequent...
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Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target
Uveal melanoma (UM) has a high risk to progress to metastatic disease with a median survival of 3.9 months after metastases detection, as metastatic...
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Patient-Derived Organoids for In Vivo Validation of In Vitro Data
Patient-derived organoids are promising tumor models for functional validation of next-generation sequencing-based therapy recommendations. In times...
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Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis
Metastasis is a fatal disease where research progress has been hindered by a lack of authentic experimental models. Here, we develop a 3D tumor...
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The EurOPDX Data Portal: an open platform for patient-derived cancer xenograft data sharing and visualization
BackgroundPatient-derived xenografts (PDX) mice models play an important role in preclinical trials and personalized medicine. Sharing data on the...
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The Chicken Embryo Chorioallantoic Membrane (CAM): A Versatile Tool for the Study of Patient-Derived Xenografts
Patient-derived xenografts represent the gold standard in pre-clinical research models. The chicken embryo chorioallantoic membrane (CAM) is used in...
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Label-free separation of neuroblastoma patient-derived xenograft (PDX) cells from hematopoietic progenitor cell products by acoustophoresis
BackgroundGraft-contaminating tumor cells correlate with inferior outcome in high-risk neuroblastoma patients undergoing hematopoietic stem cell...
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Apatinib inhibits glioma cell malignancy in patient-derived orthotopic xenograft mouse model by targeting thrombospondin 1/myosin heavy chain 9 axis
We determined the antitumor mechanism of apatinib in glioma using a patient-derived orthotopic xenograft (PDOX) glioma mouse model and glioblastoma...
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Zebrafish xenograft as a tool for the study of colorectal cancer: a review
Colorectal cancer (CRC) is the second leading cause of cancer-related death, mostly due to metastatic disease and the fact that many patients already...
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Establishment and characterization of novel high mucus-producing lung tumoroids derived from a patient with pulmonary solid adenocarcinoma
Among mucus-producing lung cancers, invasive mucinous adenocarcinoma of the lung is a rare and unique subtype of pulmonary adenocarcinoma. Notably,...
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Establishment and characterization of multiple patient-derived organoids from a case of advanced endometrial cancer
Patient-derived organoids (PDOs) retain the original tumor’s characteristics to a large degree and allow direct evaluation of the drug sensitivity,...
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Targeting HER3 or MEK overcomes acquired Trastuzumab resistance in HER2-positive gastric cancer-derived xenograft
Acquired Trastuzumab resistance is a complicated and disastrous event for HER2-positive gastric cancer (GC). In this study, we successfully...
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Creation and Development of Patient-Derived Organoids for Therapeutic Screening in Solid Cancer
Purpose of ReviewClinical implementation of personalized cancer therapy necessitates translational cancer models that faithfully represent the...
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Metastases and treatment-resistant lineages in patient-derived cancer cells of colorectal cancer
Circulating tumor cells (CTCs) play an important role in metastasis and recurrence. However, which cells comprise the complex tumor lineages in...
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Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool
In December 2022 the US Food and Drug Administration (FDA) removed the requirement that drugs in development must undergo animal testing before...
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A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology
Models that recapitulate the complexity of human tumors are urgently needed to develop more effective cancer therapies. We report a bank of human...
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Establishment and characterization of two novel patient-derived cell lines from giant cell tumor of bone
Giant cell tumor of bone (GCTB) is a rare bone tumor with osteolytic features, composed of stromal cells with a monotonous appearance, macrophages,...
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Establishment and characterization of NCC-PMP2-C1: a novel patient-derived cell line of pseudomyxoma peritonei with signet ring cells
Pseudomyxoma peritonei (PMP) is a rare phenomenon, characterized by accumulation of mucus in the abdominal cavity due to a mucinous neoplasm....
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A Xenograft Model for Venous Malformation
Xenograft models allow for an in vivo approach to monitor cellular functions within the context of a host microenvironment. Here we describe a...