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Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1
Microglia were considered as immune cells in inflammation until their angiogenic role was widely understood. Although the pro-inflammatory role of...
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Secretogranin III stringently regulates pathological but not physiological angiogenesis in oxygen-induced retinopathy
Conventional angiogenic factors, such as vascular endothelial growth factor (VEGF), regulate both pathological and physiological angiogenesis...
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IL-33 enhances Jagged1 mediated NOTCH1 intracellular domain (NICD) deubiquitination and pathological angiogenesis in proliferative retinopathy
Pathological retinal neovascularization (NV) is a clinical manifestation of various proliferative retinopathies, and treatment of NV using anti-VEGF...
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Matrix Pathobiology and Angiogenesis
In the vasculature, the extracellular matrix (ECM) is involved in the regulation of angiogenesis, vascular mechanosensing, and blood vessel stability.
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Fibronectin Fibrillogenesis During Angiogenesis
Vascular basement membrane is a critical regulator of angiogenesis. Fibronectin, a component of the vascular matrix, acts as a scaffold between the...
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Identification of the central role of RNA polymerase mitochondrial for angiogenesis
Mitochondria are central to endothelial cell activation and angiogenesis, with the RNA polymerase mitochondrial (POLRMT) serving as a key protein in...
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Hypoxia: A Potent Regulator of Angiogenesis Through Extracellular Matrix Remodelling
Angiogenesis, sprouting of new vessels from pre-existing ones, occurs throughout life in both health (physiological angiogenesis) and disease...
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A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis
BackgroundVascular endothelial growth factor (VEGF) is one of the most powerful proangiogenic factors and plays an important role in multiple...
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Recombinant thrombomodulin domain 1 rescues pathological angiogenesis by inhibition of HIF-1α-VEGF pathway
Pathological angiogenesis (PA) contributes to various ocular diseases, including age-related macular degeneration, diabetic retinopathy, and...
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MiRNAs regulate cell communication in osteogenesis-angiogenesis coupling during bone regeneration
Bone regeneration is a complex process that requires not only the participation of multiple cell types, but also signal communication between cells....
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Mechanisms of Physiological Angiogenesis
AbstractAngiogenesis is the formation of blood vessels from a pre-existing vasculature to provide optimal tissue perfusion. In the adult...
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The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy
BackgroundLong noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides in length that do not code for proteins. Initially considered a...
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The requirement of the mitochondrial protein NDUFS8 for angiogenesis
Mitochondria are important for the activation of endothelial cells and the process of angiogenesis. NDUFS8 (NADH:ubiquinone oxidoreductase core...
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Kindlin-2 controls angiogenesis through modulating Notch1 signaling
Kindlin-2 is critical for development and homeostasis of key organs, including skeleton, liver, islet, etc., yet its role in modulating angiogenesis...
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Differential angiogenesis of bone and muscle endothelium in aging and inflammatory processes
Different tissues have different endothelial features, however, the implications of this heterogeneity in pathological responses are not clear yet....
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Role of exosome-derived miRNAs in diabetic wound angiogenesis
Chronic wounds with high disability are among the most common and serious complications of diabetes. Angiogenesis dysfunction impair wound healing in...
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M2 macrophage-derived exosomes promote angiogenesis and improve cardiac function after myocardial infarction
BackgroundMyocardial infarction (MI) is a major cause of mortality and morbidity worldwide. The intercellular communication in post-infarction...
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Angiogenesis Invasion Assay to Study Endothelial Cell Invasion and Sprouting Behavior
Angiogenesis is the formation of new blood vessels from the existing vasculature. It is a fundamental process in developmental biology but also a...
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Hypoxia and low-glucose environments co-induced HGDILnc1 promote glycolysis and angiogenesis
Small bowel vascular malformation disease (SBVM) commonly causes obscure gastrointestinal bleeding (OGIB). However, the pathogenetic mechanism and...
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Leading Roles of Heparan Sulfate in Angiogenesis and Cancer
Heparan sulfate (HS) is a member of the broad family of linear heteropolysaccharides known as glycosaminoglycans (GAGs). Except for hyaluronic acid,...