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CASSPER is a semantic segmentation-based particle picking algorithm for single-particle cryo-electron microscopy
Particle identification and selection, which is a prerequisite for high-resolution structure determination of biological macromolecules via...
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DRPnet: automated particle picking in cryo-electron micrographs using deep regression
BackgroundIdentification and selection of protein particles in cryo-electron micrographs is an important step in single particle analysis. In this...
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DeepCryoPicker: fully automated deep neural network for single protein particle picking in cryo-EM
BackgroundCryo-electron microscopy (Cryo-EM) is widely used in the determination of the three-dimensional (3D) structures of macromolecules. Particle...
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PickerOptimizer: A Deep Learning-Based Particle Optimizer for Cryo-Electron Microscopy Particle-Picking Algorithms
Cryo-electron microscopy single particle analysis requires tens of thousands of particle projections for the structural determination of...
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nextPYP: a comprehensive and scalable platform for characterizing protein variability in situ using single-particle cryo-electron tomography
Single-particle cryo-electron tomography is an emerging technique capable of determining the structure of proteins imaged within the native context...
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Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs
Cryo-electron microscopy is a popular method for the determination of protein structures; however, identifying a sufficient number of particles for...
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Uncovering structural ensembles from single-particle cryo-EM data using cryoDRGN
Single-particle cryogenic electron microscopy (cryo-EM) has emerged as a powerful technique to visualize the structural landscape sampled by a...
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Structure of the preholoproteasome reveals late steps in proteasome core particle biogenesis
Assembly of the proteasome’s core particle (CP), a barrel-shaped chamber of four stacked rings, requires five chaperones and five subunit...
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TomoTwin: generalized 3D localization of macromolecules in cryo-electron tomograms with structural data mining
Cryogenic-electron tomography enables the visualization of cellular environments in extreme detail, however, tools to analyze the full amount of...
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Rapid Particle-Based Simulations of Cellular Signalling with the FLAME-Accelerated Signalling Tool (FaST) and GPUs
Cellular signalling is a vital process in living organisms for coordinating highly diverse responses to various stimuli. Particle-based modelling...
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AutoCryoPicker: an unsupervised learning approach for fully automated single particle picking in Cryo-EM images
BackgroundAn important task of macromolecular structure determination by cryo-electron microscopy (cryo-EM) is the identification of single particles...
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Single-particle cryo-EM structures from iDPC–STEM at near-atomic resolution
In electron cryomicroscopy (cryo-EM), molecular images of vitrified biological samples are obtained by conventional transmission microscopy (CTEM)...
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An Improved Soft Subspace Clustering Algorithm Based on Particle Swarm Optimization for MR Image Segmentation
Soft subspace clustering (SSC), which analyzes high-dimensional data and applies various weights to each cluster class to assess the membership...
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Auto3DCryoMap: an automated particle alignment approach for 3D cryo-EM density map reconstruction
BackgroundCryo-EM data generated by electron tomography (ET) contains images for individual protein particles in different orientations and tilted...
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ParticleChromo3D: a Particle Swarm Optimization algorithm for chromosome 3D structure prediction from Hi-C data
BackgroundThe three-dimensional (3D) structure of chromatin has a massive effect on its function. Because of this, it is desirable to have an...
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Subtomogram Averaging
Subtomogram averaging (STA) is a method to determine macromolecular structures from electron tomograms, typically in their frozen-hydrated state...
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Structures of L-BC virus and its open particle provide insight into Totivirus capsid assembly
L-BC virus persists in the budding yeast Saccharomyces cerevisiae , whereas other viruses from the family Totiviridae infect a diverse group of...
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Use of Localized Reconstruction to Visualize the Shigella Phage Sf6 Tail Apparatus
Cryogenic electron microscopy (cryo-EM) single-particle analysis has revolutionized the structural analysis of icosahedral viruses, including tailed...