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Synthesis of Novel Azabenzimidazole Bridged bis-Coumarin Compounds, Investigation of Pancreatic Lipase Inhibitory Properties, and Docking Studies
AbstractIn this study, new azabenzimidazole-bridged bis-coumarin compounds have been synthesized and screened for their pancreatic lipase inhibitory...
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Acylated Flavonoids from Cucumis sativus Inhibit the Activity of Human Pancreatic Lipase
Lipid metabolism disorders are a large group of diseases for the treatment of which various strategies are used, including the use of pancreatic...
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Pancreatic lipase-related protein 2 is selectively expressed by peritubular myoid cells in the murine testis and sustains long-term spermatogenesis
Spermatogenesis is a complicated process of germ cell differentiation that occurs within the seminiferous tubule in the testis. Peritubular myoid...
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Macromolecular Interactions of Lipoprotein Lipase (LPL)
Lipoprotein lipase (LPL) is a critical enzyme in humans that provides fuel to peripheral tissues. LPL hydrolyzes triglycerides from the cores of...
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Synthesis of Some Benzimidazole-Thiophene Hybrids as Potential Urease and Lipase Inhibitors
AbstractIn this study, some benzimidazole-thiophene hybrid compounds containing isatin and salicyl moieties were synthesized and investigated for...
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Myricetin alleviates pancreatic microcirculation and inflammation in rats with severe acute pancreatitis through FOXO1 and NF-κB pathways
BackgroundMyricetin, a flavonoid, has anti-inflammation effects and can improve pancreatic β cells dysfunction. However, the role of myricetin in...
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Sequencing analysis and efficient biodiesel production by lipase from Pseudomonas aeruginosa
BackgroundRecently, lipase processing for biodiesel production has shown a global increase as it is considered a potential alternative clean-fuel...
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Innovative approach for semi‐continuous production of puerarin palmitate via transesterification with novel immobilized lipase
BackgroundPuerarin, a flavonoid abundantly found in the roots of Pueraria lobata , exhibits antioxidant, anti-cancer, anti-inflammatory, and...
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Immobilized Lipase for Industrial Biodiesel Production
The advent of biodiesel is set to usher in a new era of adaptive and environment-friendly fuel with depleting petroleum reserves. With the...
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Activation of AMPK ameliorates acute severe pancreatitis by suppressing pancreatic acinar cell necroptosis in obese mice models
Obese people with acute pancreatitis (AP) have an increased risk of develo** severe acute pancreatitis (SAP), which prolongs the length of hospital...
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Pancreatic adenocarcinoma treated with surgical resection, toceranib phosphate and firocoxib in a dog: a case report
Exocrine pancreatic carcinomas are rarely reported in dogs. A ductal pancreatic adenocarcinoma in a 10-year-old intact beagle is described in this...
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Intrapancreatic fat, pancreatitis, and pancreatic cancer
Pancreatic cancer is typically detected at an advanced stage, and is refractory to most forms of treatment, contributing to poor survival outcomes....
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Evaluation of potential of miR-8073 and miR-642 as diagnostic markers in pancreatic cancer
BackgroundPancreatic cancer is a cancer with an insidious course. Since disease is often diagnosed at advanced stages, clinical outcome is impaired....
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Bax Inhibitor-1 preserves pancreatic β-cell proteostasis by limiting proinsulin misfolding and programmed cell death
The prevalence of diabetes steadily increases worldwide mirroring the prevalence of obesity. Endoplasmic reticulum (ER) stress is activated in...
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Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress
Triple-negative breast cancer (TNBC) has a poor clinical outcome, due to a lack of actionable therapeutic targets. Herein we define lysosomal acid...
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Diacylglycerol lipase alpha promotes hepatocellular carcinoma progression and induces lenvatinib resistance by enhancing YAP activity
As an important hydrolytic enzyme that yields 2-AG and free fatty acids, diacylglycerol lipase alpha (DAGLA) is involved in exacerbating malignant...
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Waste Derived Supports for Immobilization of Lipase Towards Enhancing Efficiency and Reusability of Enzymes
The biorefineries plays vital role in maintaining energy symmetry which is a critical factor that controls the socio-economic development of any...
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Pancreatic acinar cell fate relies on system xC- to prevent ferroptosis during stress
Acinar cell dedifferentiation is one of the most notable features of acute and chronic pancreatitis. It can also be the initial step that facilitates...
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Application of exosomes in the diagnosis and treatment of pancreatic diseases
Pancreatic diseases, a serious threat to human health, have garnered considerable research interest, as they are associated with a high mortality...
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Suppression of Exocrine Pancreatic Function in Laying Hens at Oviposition
AbstractThe results of the survey with 280-day-old and older cross Hisex-White chickens that underwent complex surgery and were implanted with...
