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Palmatine ameliorates high fat diet induced impaired glucose tolerance
BackgroundThe impaired glucose tolerance (IGT) is a representative prediabetes characterized by defective glucose homeostasis, and palmatine (PAL) is...
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Elite chemotype selection, antipathogenic activities, secondary metabolite fingerprinting of in vitro regenerated Tinospora cordifolia (Willd.) Hook.f. & Thomson – a plant with multipurpose therapeutic significance
Tinospora cordifolia (Willd.) Hook.f. & Thomson is an ethnomedicinal plant belonging to the family Menispermaceae, known for its multi-disciplinary...
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Transcriptome analysis reveals the potential mechanism of altering viability, yield, and isoquinoline alkaloids in Coptis chinensis through Cunninghamia lanceolata understory cultivation
The dried rhizomes of Coptis chinensis hold significance in Chinese medicine. Monocrop** C. chinensis under the shade of a manmade scaffold, the...
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Antifungal alkaloids from Mahonia fortunei against pathogens of postharvest fruit
Postharvest pathogens can affect a wide range of fresh fruit and vegetables, including grapes, resulting in significant profit loss. Isoquinoline...
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Epiberberine: a potential rumen microbial urease inhibitor to reduce ammonia release screened by targeting UreG
AbstractRumen microbial urease inhibitors have been proposed for regulating nitrogen emission and improving nitrogen utilization efficiency in...
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Systematic analysis on the mechanism of Zhizi-Bopi decoction against hepatitis B via network pharmacology and molecular docking
Purpose: Zhizi-Bopi decoction (ZZBPD) is a classic herbal formula with wide clinical applications in treating liver diseases including hepatitis B....
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Plant-Derived Immunomodulators Targeting COVID-19 (SARS-CoV-2): Preclinical Evaluation and Clinical Trials
Coronavirus disease-2019 (COVID-19) is a contagious disease that originated and proliferated via a novel viral strain named Severe Acute Respiratory... -
Alkaloids as potential antivirals. A comprehensive review
Alkaloids are a diverse group of natural phytochemicals. These phytochemicals in plants provide them protection against pests, and herbivorous...
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The columbamine O-methyltransferase gene (CoOMT) is capable of increasing alkaloid content in transgenic tobacco plants
BackgroundIn the alkaloid biosynthetic pathways of Stephania and Rannunculaceae, columbamine O-methyltransferase ( CoOMT ) is an important enzyme that...
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Huanglian-Hongqu herb pair improves nonalcoholic fatty liver disease via NF-κB/NLRP3 pathway in mice: network pharmacology, molecular docking and experimental validation
The Huanglian-Hongqu herb pair (HH) is a carefully crafted traditional Chinese herbal compound designed to address disorders related to glucose and...
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Coptis rhizome extract influence on Streptococcus pneumoniae through autolysin activation
This study investigated the antibacterial properties of Coptis rhizome , a plant traditionally used for respiratory infections, against Streptoccus...
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Role of Medicinal Plants in the Management of Diabetes Mellitus
Since ancient times, cure or prevention of diseases by medicinal plants was being practiced by indigenous people of different communities around the... -
Secondary Metabolites Biosynthesis and Related Gene Expression Under Ultraviolet-B Radiation
Plants have a diverse array of secondary metabolites as part of their defense mechanism against various stress conditions. These secondary... -
Mechanism of antibacterial phytoconstituents: an updated review
The increase of multiple drug resistance bacteria significantly diminishes the effectiveness of antibiotic armory and subsequently exaggerates the...
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Integrated metabolomic and transcriptomic analyses provide insights into regulation mechanisms during bulbous stem development in the Chinese medicinal herb plant, Stephania kwangsiensis
BackgroundStephania kwangsiensis Lo (Menispermaceae) is a well-known Chinese herbal medicine, and its bulbous stems are used medicinally. The...
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Dynamicity and extractability of hydro-alcoholic solvents for Tinospora cordifolia stem: an investigation for target-oriented traditional drug discovery based on biologically active phytocompounds
Hydro-alcoholic solvents play a vital role in traditional drug discovery from plants. Phytocompounds extracted from plants using hydro-alcoholic...
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Chemopreventive Strategies in Herbal Medicine Practice: Current Aspects, Challenges, Prospects, and Sustainable Future Outlook
Cancer is one of the high-profile diseases and is responsible for millions of deaths worldwide every year. Even though there are many therapeutic... -
Chemopreventive Strategies in Herbal Medicine Practice: Current Aspects, Challenges, Prospects, and Sustainable Future Outlook
Cancer is one of the high-profile diseases and is responsible for millions of deaths worldwide every year. Even though there are many therapeutic... -
Binding and stabilizating effect of RNA triplex poly(U)⋅poly(A)*poly(U) by enantiomers of ruthenium(II) polypyridyl complex [Ru(bpy)2(dppx)]2+
Two chiral ruthenium(II) polypyridyl complexes, Λ-[Ru(bpy) 2 (dppx)] 2+ (bpy = 2,2′-bipyridine, dppx = 7,8-dimethyldipyridophenazine; Λ- 1 ) and Δ-[Ru(bpy)
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The chromosome-level reference genome of Coptis chinensis provides insights into genomic evolution and berberine biosynthesis
Coptis chinensis Franch, a perennial herb, is mainly distributed in southeastern China. The rhizome of C. chinensis has been used as a traditional...