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1. Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review

   Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various...

   Katarzyna Kolczynska, Angel Loza-Valdes, ... Grzegorz Sumara in Lipids in Health and Disease

   Article Open access 28 May 2020
   

2. Genome-wide alternative splicing profile in the posterior kidney of brown trout (Salmo trutta) during proliferative kidney disease

   Background

   The cnidarian myxozoan parasite Tetracapsuloides bryosalmonae causes chronic proliferative kidney disease (PKD) in salmonids. This...

   Arun Sudhagar, Mansour El-Matbouli, Gokhlesh Kumar in BMC Genomics

   Article Open access 16 June 2022
   

3. Addressing the role of PKD3 in the T cell compartment with knockout mice

   Background

   The Protein kinase D3 (PKD3) has been implicated in signal transduction downstream of the T cell receptor (TCR). However, its role for the...

   Jiří Koutník, Verena Neururer, ... Kerstin Siegmund in Cell Communication and Signaling

   Article Open access 19 April 2022
   

4. Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling

   Breast cancer stem cells (BCSCs) are essential for cancer growth, metastasis and recurrence. The regulatory mechanisms of BCSC interactions with the...

   Yinan Jiang, Yichen Guo, ... Bin Ren in Communications Biology

   Article Open access 24 June 2021
   

5. Dopamine D1- and D2-like receptors oppositely regulate lifespan via a dietary restriction mechanism in Caenorhabditis elegans

   Background

   Despite recent progress in understanding the molecular mechanisms regulating aging and lifespan, and the pathways involved being conserved...

   Yizhou Jiang, Uma Gaur, ... Wenhua Zheng in BMC Biology

   Article Open access 23 March 2022
   

6. Metabolic derangement in polycystic kidney disease mouse models is ameliorated by mitochondrial-targeted antioxidants

   Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressively enlarging cysts. Here we elucidate the interplay between...

   Nastaran Daneshgar, Andrew W. Baguley, ... Dao-Fu Dai in Communications Biology

   Article Open access 20 October 2021
   

7. 5-IP₇ is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis

   5-diphosphoinositol pentakisphosphate (5-IP ₇ ) is a signalling metabolite linked to various cellular processes. How extracellular stimuli elicit 5-IP ₇ ...

   **aozhe Zhang, Na Li, ... Feng Rao in Nature Metabolism

   Article 18 October 2021
   

8. Identification and in silico characterization of a novel PKLR genotype in a Turkish newborn

   Pyruvate kinase deficiency (PKD) is the most common glycolytic defect leading to chronic nonspherocytic hemolytic anemia (CNSHA). Clinical...

   Giulia Canu, Elisa De Paolis, ... Angelo Minucci in Molecular Biology Reports

   Article 24 September 2020
   

9. The tyrosine-kinase inhibitor Nintedanib ameliorates autosomal-dominant polycystic kidney disease

   Autosomal-dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease and is characterized by progressive growth of...

   Abeda Jamadar, Sreenath M. Suma, ... Reena Rao in Cell Death & Disease

   Article Open access 14 October 2021
   

10. Exploring kinase family inhibitors and their moiety preferences using deep SHapley additive exPlanations

    Background

    While it has been known that human protein kinases mediate most signal transductions in cells and their dysfunction can result in...

    You-Wei Fan, Wan-Hsin Liu, ... **n-Moon Yang in BMC Bioinformatics

    Article Open access 20 June 2022
    

11. PATJ inhibits histone deacetylase 7 to control tight junction formation and cell polarity

    The conserved multiple PDZ-domain containing protein PATJ stabilizes the Crumbs-Pals1 complex to regulate apical-basal polarity and tight junction...

    Julia Fiedler, Thomas Moennig, ... Michael P. Krahn in Cellular and Molecular Life Sciences

    Article Open access 25 October 2023
    

12. Genetic interactions between Protein Kinase D and Lobe mutants during eye development of Drosophila melanogaster

    Background

    In Drosophila, the development of the fly eye involves the activity of several, interconnected pathways that first define the presumptive...

    Dieter Maier, Anja C. Nagel, Anette Preiss in Hereditas

    Article Open access 19 December 2019
    

13. CARTS Formation Assay

    Sorting and transport of secretory and membrane proteins occur at the trans-Golgi network (TGN). Carriers of the TGN to the cell surface (CARTS) are...

    Yuichi Wakana, Mitsuo Tagaya in Golgi

    Protocol 2023
    

14. Emerging mechanistic understanding of cilia function in cellular signalling

    Primary cilia are solitary, immotile sensory organelles present on most cells in the body that participate broadly in human health, physiology and...

    Keren I. Hilgendorf, Benjamin R. Myers, Jeremy F. Reiter in Nature Reviews Molecular Cell Biology

    Article 16 February 2024
    

15. Genome-wide identification and immune response analysis of mitogen-activated protein kinase cascades in tea geometrid, Ectropis grisescens Warren (Geometridae, Lepidoptera)

    Background

    Tea geometrid Ectropis grisescens (Geometridae: Lepidoptera), is one of the most destructive defoliators in tea plantations in China. The...

    **aozhu Wu, Chenghua Zhou, ... Liande Wang in BMC Genomics

    Article Open access 22 June 2023
    

16. RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria

    Mitophagy, a mitochondria-specific form of autophagy, removes dysfunctional mitochondria and is hence an essential process contributing to...

    Michelle Tu, Valerie P. Tan, ... Shigeki Miyamoto in Cell Death & Differentiation

    Article Open access 27 June 2022
    

17. Role of Titin Phosphorylation in Myocardial Stiffness Changes during Cardiomyopathies

    Abstract

    The review provides a brief analysis of the current knowledge of such a post-translational modification of titin as phosphorylation, with a...

    G. Z. Mikhailova, I. M. Vikhlyantsev, V. L. Lakomkin in Journal of Evolutionary Biochemistry and Physiology

    Article 01 March 2024
    

18. Holistic expression of miR-17-92 cluster in obesity, kidney diseases, cardiovascular diseases, and diabetes

    miR-17-92 cluster encodes six micro RNAs (miRNAs) and plays a crucial role in the regulation of various cellular processes. Aberrant expression of...

    Maheen Ejaz, Syed Mohammad Usman, ... Muhammad Jawad Khan in Molecular Biology Reports

    Article 17 June 2023
    

19. Identification of transient receptor potential channel genes from the swimming crab, Portunus Trituberculatus, and their expression profiles under acute temperature stress

    Background

    Temperature is an important environment factor that is critical to the survival and growth of crustaceans. However, the mechanisms by which...

    Yichen Qian, Qiaoling Yu, ... Dongfa Zhu in BMC Genomics

    Article Open access 17 January 2024
    

20. First report on chemometrics-driven multilayered lead prioritization in addressing oxysterol-mediated overexpression of G protein-coupled receptor 183

    Contemporary research has convincingly demonstrated that upregulation of G protein-coupled receptor 183 (GPR183), orchestrated by its endogenous...

    Arnab Bhattacharjee, Supratik Kar, Probir Kumar Ojha in Molecular Diversity

    Article 09 March 2024