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TRPM5 activation depends on a synergistic effect of calcium and PKC phosphorylation
Transient receptor potential melastatin 5 (TRPM5) is a calcium-activated monovalent-specific ion channel involved in insulin secretion and taste...
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Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in mice
Kidney fibrosis is considered to be the ultimate aggregation pathway of chronic kidney disease (CKD), but its underlying mechanism remains elusive....
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The RXFP2-PLC/PKC signaling pathway mediates INSL3-induced regulation of the proliferation, migration and apoptosis of mouse gubernacular cells
BackgroundTesticular hypoplasia can affect the sexual and reproductive ability in adulthood, and even increase the risk of cancer. Abnormal...
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Temperature-induced embryonic diapause in chickens is mediated by PKC-NF-κB-IRF1 signaling
BackgroundEmbryonic diapause (dormancy) is a state of temporary arrest of embryonic development that is triggered by unfavorable conditions and...
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PKC-β modulates Ca2+ mobilization through Stim1 phosphorylation
BackgroundCalcium ions play a pivotal role in cell proliferation, differentiation, and migration. Under basal conditions, the calcium level is...
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Phosphorylation of PP2Ac by PKC is a key regulatory step in the PP2A-switch-dependent AKT dephosphorylation that leads to apoptosis
BackgroundAlthough GqPCR activation often leads to cell survival by activating the PI3K/AKT pathway, it was previously shown that in several cell...
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TRPM2 promotes pancreatic cancer by PKC/MAPK pathway
The mechanism of pancreatic cancer (PA) is not fully understanded. In our last report, TRPM2 plays a promising role in pancreatic cancer. However,...
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Amyloid β / PKC-dependent alterations in NMDA receptor composition are detected in early stages of Alzheimer´s disease
Amyloid beta (Aβ)-mediated synapse dysfunction is an early event in Alzheimer’s disease (AD) pathogenesis and previous studies suggest that NMDA...
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Elucidation of an mTORC2-PKC-NRF2 pathway that sustains the ATF4 stress response and identification of Sirt5 as a key ATF4 effector
Proliferating cancer cells are dependent on glutamine metabolism for survival when challenged with oxidative stresses caused by reactive oxygen...
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PKC-SWI6 signaling regulates asexual development, cell wall integrity, stress response, and lifestyle transition in the nematode-trap** fungus Arthrobotrys oligospora
Predatory fungi possess intricate signal transduction systems that regulate their development and support successful infection of the host. Herein,...
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Matrix vesicles from dental follicle cells improve alveolar bone regeneration via activation of the PLC/PKC/MAPK pathway
BackgroundThe regeneration of bone loss that occurs after periodontal diseases is a significant challenge in clinical dentistry. Extracellular...
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Activation of YAP regulates muscle fiber size in a PKC-dependent mechanism during chick in vitro myogenesis
The formation of skeletal muscle fibers is an intricate process controlled by a multitude of signaling pathways, including Wnt, Shh, and FGF....
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PKC downregulation upon rapamycin treatment attenuates mitochondrial disease
Leigh syndrome is a fatal neurometabolic disorder caused by defects in mitochondrial function. Mechanistic target of rapamycin (mTOR) inhibition with...
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Tectoridin inhibits the progression of colon cancer through downregulating PKC/p38 MAPK pathway
Colon cancer is one of the most familiar malignancies worldwide, with high morbidity and high mortality. This study intended to explore the role and...
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Stress granules safeguard against MAPK signaling hyperactivation by sequestering PKC/Pck2: new findings and perspectives
Stress granule (SG) assembly is a conserved cellular strategy that copes with stress-related damage and promotes cell survival. SGs form through a...
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Classical isoforms of protein kinase C (PKC) and Akt regulate the osteogenic differentiation of human dental follicle cells via both β-catenin and NF-κB
BackgroundHuman dental follicle cells (DFCs) are the precursor cells of the periodontium with a high potential for regenerative therapies of...
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PKC-δ deficiency in B cells displays osteopenia accompanied with upregulation of RANKL expression and osteoclast–osteoblast uncoupling
PKC-δ is an important molecule for B-cell proliferation and tolerance. B cells have long been recognized to play a part in osteoimmunology and...
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A novel PKC activating molecule promotes neuroblast differentiation and delivery of newborn neurons in brain injuries
Neural stem cells are activated within neurogenic niches in response to brain injuries. This results in the production of neuroblasts, which...
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Effects of palm kernel cake on nutrient utilization and performance of grazing and confined cattle: a meta-analysis
A meta-analysis was conducted to evaluate the effects of dietary palm kernel cake inclusion (PKC Inclusion ) on the nutrient intake and digestibility,...
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Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review
Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various...
