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Identification and integrated analysis of lncRNAs and miRNAs in IPEC-J2 cells provide novel insight into the regulation of the innate immune response by PDCoV infection
BackgroundNoncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are pivotal regulators involved in the pathogenic...
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Epidemiology, pathogenesis, immune evasion mechanism and vaccine development of porcine Deltacoronavirus
Coronaviruses have been identified as pathogens of gastrointestinal and respiratory diseases in humans and various animal species. In recent years,...
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Development of an RT-PCR-based RspCas13d system to detect porcine deltacoronavirus
AbstractPorcine deltacoronavirus (PDCoV) is an enteropathogen that causes diarrhea in piglets and may undergo cross-species transmission. The...
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Production of Plant-Based Recombinant Vaccine Against Porcine Deltacoronavirus in the Form of Bacteria-Like Particles Using Lactococcus lactis
Porcine deltacoronavirus (PDCoV) is an enteropathogenic swine coronavirus that causes severe diarrheal disease in suckling piglets and young pigs,...
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Development of a CRISPR-Cas12a based assay for the detection of swine enteric coronaviruses in pig herds in China
Porcine epidemic diarrhea virus (PEDV), Transmissible gastroenteritis virus (TGEV), Porcine deltacoronavirus (PDCoV) and Swine acute diarrhea...
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Identification of a novel linear B-cell epitope in porcine deltacoronavirus nucleocapsid protein
AbstractPorcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus that caused diarrhea and/or vomiting in neonatal piglets...
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Development of a novel double-antibody sandwich quantitative ELISA for detecting SADS-CoV infection
AbstractSwine acute diarrhea syndrome coronavirus (SADS-CoV) is an emerging swine enteric alphacoronavirus that can cause acute diarrhea, vomiting,...
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Use of dual priming oligonucleotide system-based multiplex RT-PCR assay to detect five diarrhea viruses in pig herds in South China
In this study, a specific and simple method based on the dual priming oligonucleotide (DPO) system was developed to simultaneously detect...
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Porcine enteric coronaviruses: an updated overview of the pathogenesis, prevalence, and diagnosis
The recent prevalence of coronavirus (CoV) poses a serious threat to animal and human health. Currently, porcine enteric coronaviruses (PECs),...
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Peroxisomes and Viruses: Overview on Current Knowledge and Experimental Approaches
The general interest in the study of the interplay between peroxisomes and viruses has increased in recent years, with different reports... -
Therapeutic Potential of Medicinal Mushrooms: Insights into Its Use Against Covid-19
Disease outbreaks have devastated mankind throughout history, altering the course of history and, in some cases, marking the end of entire... -
Pyrococcus furiosus Argonaute-mediated porcine epidemic diarrhea virus detection
AbstractPorcine epidemic diarrhea virus (PEDV), an enteric coronavirus, induces severe vomiting and acute watery diarrhea in unweaned piglets. The...
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Improve meat production and virus resistance by simultaneously editing multiple genes in livestock using Cas12iMax
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated gene (Cas) system is continually optimized to achieve the...
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Rapid detection of porcine circovirus type 2 by a red latex microsphere immunochromatographic strip
AbstractTo establish a rapid and specific antigen detection method for porcine circovirus type 2 (PCV2), monoclonal antibodies (mAbs) were produced...
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Improvements in pig agriculture through gene editing
Genetic modification of animals via selective breeding is the basis for modern agriculture. The current breeding paradigm however has limitations,...
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A novel recombinant porcine sapovirus infection in piglets with diarrhea in Shandong Province, China, 2022
Sapporo virus (SaV) is an emerging enteric virus causing acute gastroenteritis in animals. Here, we found a novel porcine SaV (PoSaV) strain (named...
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Paneth cells in farm animals: current status and future direction
A healthy intestine plays an important role in the growth and development of farm animals. In small intestine, Paneth cells are well known for their...
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Phylogenetic analysis and molecular characterization of the co-infection of the new variant of the porcine epidemic diarrhea virus and the novel porcine kobuvirus isolated from piglets with diarrhea
Porcine epidemic diarrhea virus (PEDV) is a virus that can cause diarrhea in pigs, resulting in significant economic losses to the pig industry. The...
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A comprehensive review of SARS-CoV-2 genetic mutations and lessons from animal coronavirus recombination in one health perspective
SARS-CoV-2 was originated from zoonotic coronaviruses and confirmed as a novel beta-coronavirus, which causes serious respiratory illness such as...
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A TaqMan-probe-based multiplex real-time RT-qPCR for simultaneous detection of porcine enteric coronaviruses
Swine enteric coronaviruses are a group of most significant pathogens causing diarrhea in piglets with similar clinical symptoms and pathological...