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Generation of Organoids and Analysis of Ferroptosis in Organoids
Ferroptosis is a unique form of iron-dependent cell death induced by lipid peroxidation and subsequent plasma membrane rupture, which sets it apart...
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Renal Organoids from Whole Kidney Cells
Organoid technology, as a three-dimensional (3D) culture method, provides a feasible tool to self-organize multiple types of organ-specific cells,...
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Mechanical Actuation of Organoids in Synthetic Microenvironments
Organoids are a powerful model system to explore the role of mechanical forces in sculpting emergent tissue cytoarchitecture. The modulation of the...
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Development of Organoids to Study Infectious Host Interactions
Emerging organoid research is paving way for studies in infectious diseases. Described here is a technique for the generation of stem-cell derived...
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Standard: Human intestinal organoids
Organoids have attracted great interest for disease modelling, drug discovery and development, and tissue growth and homeostasis investigations....
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Organoids Models of Pancreatic Duct Adenocarcinoma
Three-dimensional (3D) organoid culture is a laboratory technique used to grow and study miniature organs that mimic the structure and function of...
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Current applications of intestinal organoids: a review
In the past decade, intestinal organoid technology has paved the way for reproducing tissue or organ morphogenesis during intestinal physiological...
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Human cytomegalovirus (CMV) dysregulates neurodevelopmental pathways in cerebral organoids
Human cytomegalovirus (CMV) infection is the leading non-genetic aetiology of congenital malformation in developed countries, causing significant...
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Osteochondral organoids: current advances, applications, and upcoming challenges
In the realm of studying joint-related diseases, there is a continuous quest for more accurate and representative models. Recently, regenerative...
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Standard: Human intestinal cancer organoids
Intestinal cancer is one of the most frequent and lethal types of cancer. Modeling intestinal cancer using organoids has emerged in the last decade....
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Stem Cell-Derived Neural Organoids: From the Origin to Next Generation
The advance of stem cell research has enabled researchers to generate organoids: three-dimensional tissues with biological structures and functions....
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Tumor Organoids: The Era of Personalized Medicine
AbstractThe strategies of future medicine are aimed to modernize and integrate quality approaches including early molecular-genetic profiling,...
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Potential Application of Intestinal Organoids in Intestinal Diseases
To accurately reveal the scenario and mecahnism of gastrointestinal diseases, the establishment of in vitro models of intestinal diseases and drug...
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Lung Organoids: Systematic Review of Recent Advancements and its Future Perspectives
Organoids are essentially an in vitro (lab-grown) three-dimensional tissue culture system model that meticulously replicates the structure and...
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Spatiotemporal, optogenetic control of gene expression in organoids
Organoids derived from stem cells have become an increasingly important tool for studying human development and modeling disease. However, methods...
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Advances in Organoid Technology: A Focus on Corneal Limbal Organoids
Organoid technology provides a versatile platform for simulating organogenesis, investigating disease pathogenesis, and exploring therapeutic...
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SOX2 and OCT4 mediate radiation and drug resistance in pancreatic tumor organoids
Pancreatic cancer has a five-year survival rate of only 10%, mostly due to late diagnosis and limited treatment options. In patients with...
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Cerebral organoids display dynamic clonal growth and tunable tissue replenishment
During brain development, neural progenitors expand through symmetric divisions before giving rise to differentiating cell types via asymmetric...
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Advancements in understanding bacterial enteritis pathogenesis through organoids
Bacterial enteritis has a substantial role in contributing to a large portion of the global disease burden and serves as a major cause of newborn...
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Establishment of human hematopoietic organoids for evaluation of hematopoietic injury and regeneration effect
BackgroundHuman hematopoietic organoids have a wide application value for modeling human bone marrow diseases, such as acute hematopoietic radiation...
