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CRISPR Interference (CRISPRi) Mediated Suppression of OmpR Gene in E. coli: An Alternative Approach to Inhibit Biofilm
Biofilm plays an important role in the community and hospital-acquired infections. Especially E. coli biofilm that contributes towards the...
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Multifaceted regulation of siderophore synthesis by multiple regulatory systems in Shewanella oneidensis
Siderophore-dependent iron uptake is a mechanism by which microorganisms scavenge and utilize iron for their survival, growth, and many specialized...
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H3-T6SS of Pseudomonas aeruginosa PA14 contributes to environmental adaptation via secretion of a biofilm-promoting effector
Microbial species often occur in complex communities and exhibit intricate synergistic and antagonistic interactions. To avoid predation and compete...
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Navigating the signaling landscape of Ralstonia solanacearum: a study of bacterial two-component systems
Ralstonia solanacearum , the bacterium that causes bacterial wilt, is a destructive phytopathogen that can infect over 450 different plant species....
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Molecular mechanism of siderophore regulation by the Pseudomonas aeruginosa BfmRS two-component system in response to osmotic stress
Pseudomonas aeruginosa , a common nosocomial pathogen, relies on siderophores to acquire iron, crucial for its survival in various environments and...
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Engineering Whole-Cell Biosensors for Enhanced Detection of Environmental Antibiotics Using a Synthetic Biology Approach
Bacterial Two component systems have evolved with many intricate sensory apparatuses for external stimuli like light, temperature, oxygen, pH and...
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Structural Insights into Regulation of Vibrio Virulence Gene Networks
One of the best studied aspects of pathogenic Vibrios are the virulence cascades that lead to the production of virulence factors and, ultimately,...
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Genomic insights into the molecular mechanisms of a Pseudomonas strain significant in its survival in Kongsfjorden, an Arctic fjord
Whole-genome sequence of Pseudomonas sp. Kongs-67 retrieved from Kongsfjorden, an Arctic fjord, has been investigated to understand the molecular...
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The role of the type VI secretion system in the stress resistance of plant-associated bacteria
The type VI secretion system (T6SS) is a powerful bacterial molecular weapon that can inject effector proteins into prokaryotic or eukaryotic cells,...
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Determining the potential targets of silybin by molecular docking and its antibacterial functions on efflux pumps and porins in uropathogenic E. coli
BackgroundOne of the causes of antibiotic resistance is the reduced accumulation of antibiotics in bacterial cells through pum** out the drugs....
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Comparative bacteriome and antibiotic resistome analysis of water and sediment of the Ganga River of India
A comparative analysis between water and sediment can provide better information to understand the dynamics of the inhabitant microbiome and their...
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What do we know about osmoadaptation of Yersinia pestis?
The plague agent Yersinia pestis mainly spreads among mammalian hosts and their associated fleas. Production of a successful mammal–flea–mammal life...
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The osmotic stress response operon betIBA is under the functional regulation of BetI and the quorum-sensing regulator AnoR in Acinetobacter nosocomialis
Adaptation to changing environmental conditions is crucial for the survival of microorganisms. Bacteria have evolved various mechanisms to cope with...
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Genome-scale identification and comparative analysis of transcription factors in thermophilic cyanobacteria
BackgroundThe transcription factors (TFs) in thermophilic cyanobacteria might represent a uniquely evolved gene repertoire in light of the strong...
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The Determination, Monitoring, Molecular Mechanisms and Formation of Biofilm in E. coli
Biofilms are cell assemblies embedded in an exopolysaccharide matrix formed by microorganisms of a single or many different species. This matrix in...
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Regulation of the AcrAB efflux system by the quorum-sensing regulator AnoR in Acinetobacter nosocomialis
Multidrug efflux pumps play an important role in antimicrobial resistance and pathogenicity in bacteria. Here, we report the functional...
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Reciprocal Regulation of OmpR and Hfq and Their Regulatory Actions on the Vi Polysaccharide Capsular Antigen in Salmonella enterica Serovar Typhi
Salmonella enterica serovar Typhi ( S . Typhi) is the causative agent of human typhoid fever. S . Typhi expresses a major virulence determinant called...
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What goes underground comes around: the molecular basis of crosstalk between plants and soil microorganisms
The co-existence of plants and microorganisms throughout their evolution resulted in an intertwined ecological network that serves as the basis for...
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Exploration of genes encoding KEGG pathway enzymes in rhizospheric microbiome of the wild plant Abutilon fruticosum
The operative mechanisms and advantageous synergies existing between the rhizobiome and the wild plant species Abutilon fruticosum were studied....
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Production of ammonia as a low-cost and long-distance antibiotic strategy by Streptomyces species
Soil-inhabiting streptomycetes are nature’s medicine makers, producing over half of all known antibiotics and many other bioactive natural products....
