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Differential expression of circRNAs during osteogenic/odontogenic differentiation of stem cells from apical papilla promoted by blue light-emitting diode
BackgroundCircular RNA (circRNA) is a key player in regulating the multidirectional differentiation of stem cells. Previous research by our group...
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CDC42-mediated Wnt signaling facilitates odontogenic differentiation of DPCs during tooth root elongation
BackgroundCDC42 is a member of Rho GTPase family, acting as a molecular switch to regulate cytoskeleton organization and junction maturation of...
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The effects of melatonin on the viability and osteogenic/odontogenic differentiation of human stem cells from the apical papilla
BackgroundAn experimental study was conducted to examine whether melatonin influences osteogenic/odontogenic differentiation of human stem cells...
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lncRNA SNHG1 regulates odontogenic differentiation of human dental pulp stem cells via miR-328-3p/Wnt/β-catenin pathway
BackgroundElucidating the mechanism of odontogenic differentiation of human dental pulp stem cells (hDPSCs) is the key to in-depth mastery and...
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Long non-coding RNA IGFBP7-AS1 accelerates the odontogenic differentiation of stem cells from human exfoliated deciduous teeth by regulating IGFBP7 expression
Stem cells from human exfoliated deciduous teeth (SHED) are attractive seed cells for dental tissue engineering. We identified the effect of the long...
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Crucial Factors Influencing the Involvement of Odontogenic Exosomes in Dental Pulp Regeneration
Recent progress in exosome based studies has revealed that they possess several advantages over cells, including "cell-free" properties, low...
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Amphiregulin regulates odontogenic differentiation of dental pulp stem cells by activation of mitogen-activated protein kinase and the phosphatidylinositol 3-kinase signaling pathways
BackgroundHuman dental pulp stem cells (hDPSCs) have received widespread attention in the fields of tissue engineering and regenerative medicine....
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Combined Application of Dentin Noncollagenous Proteins and Odontogenic Biphasic Calcium Phosphate in Rabbit Maxillary Sinus Lifting
Background:Teeth can be used as a raw material for preparing bone substitutes due to their similar chemical composition to bone. The objective of our...
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Discovery of metabolite biomarkers for odontogenic keratocysts
IntroductionOdontogenic keratocysts (OKCs) are locally aggressive and have a high rate of recurrence, but the pathogenesis of OKCs is not fully...
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Extracellular Vesicles Carrying RUNX3 Promote Differentiation of Dental Pulp Stem Cells
Background:This study aims to clarify the mechanism underlying dental pulp cells-extracellular vesicles (DPC–EVs) carrying runt-related transcription...
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Significance of EGFR investigation in odontogenic keratocyst: a narrative review
BackgroundThe recent classification of odontogenic keratocysts (OKSs) recognized them as benign neoplasms, although previous findings have revealed...
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Agarose-based spheroid culture enhanced stemness and promoted odontogenic differentiation potential of human dental follicle cells in vitro
Human dental follicle cells (HDFCs) are an ideal cell source of stem cells for dental tissue repair and regeneration and they have great potential...
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MicroRNAs-mediated regulation of the differentiation of dental pulp-derived mesenchymal stem cells: a systematic review and bioinformatic analysis
BackgroundHuman dental pulp-derived mesenchymal stem cells (hDP-MSCs), which include human dental pulp stem cells (hDPSCs) and stem cells from human...
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Genome-wide identification of potential odontogenic genes involved in the dental epithelium-mesenchymal interaction during early odontogenesis
BackgroundEpithelium-mesenchymal interactions are involved in odontogenic processes. Previous studies have focused on the intracellular signalling...
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Autophagy-Related Protein MAP1LC3C Plays a Crucial Role in Odontogenic Differentiation of Human Dental Pulp Cells
Background:Autophagy plays important roles in odontogenic differentiation of dental pulp cells (DPCs) in the developmental stage of tooth bud. Few...
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Effect of magnesium oxide nanoparticles and LED irradiation on the viability and differentiation of human stem cells of the apical papilla
PurposeCurrently, regenerative endodontic treatments are gaining more and more attention, and stem cells play a significant role in these treatments....
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Circular RNA-Mediated Regulation of Oral Tissue-Derived Stem Cell Differentiation: Implications for Oral Medicine and Orthodontic Applications
Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNAs (ncRNAs) which unlike linear RNAs, have a covalently closed continuous loop...
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Effects of CEM cement and emdogain on proliferation and differentiation of human stem cells from the apical papilla: a comparative in vitro study
ObjectivesThis study compared the effects of calcium-enriched mixture (CEM) cement, Emdogain (EMD), and their combination (CEM/Emdogain) on the...
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Dental follicle cells show potential for treating Parkinson’s disease through dopaminergic-neuronogenic differentiation
Among all the adult stem cells, odontogenic stem cells inherit the characterization of neurogenic potential of their precursor ones–the cranial crest...
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New diagnostic molecular markers and biomarkers in odontogenic tumors
Odontogenic tumors comprised of complex heterogeneous lesions that diverse from harmatomas to malignant tumors with different behavior and histology....
