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Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway
BackgroundDegenerative disc disease(DDD)is one of the most important causes of low back pain (LBP). Programmed death of human nucleus pulposus...
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Pretreatment of nucleus pulposus mesenchymal stem cells with appropriate concentration of H2O2 enhances their ability to treat intervertebral disc degeneration
BackgroundNucleus pulposus mesenchymal stem cells (NPMSCs) transplantation is a promising treatment for intervertebral disc degeneration (IVDD)....
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The dual role of mesenchymal stem cells in apoptosis regulation
Mesenchymal stem cells (MSCs) are widely distributed pluripotent stem cells with powerful immunomodulatory capacity. MSCs transplantation therapy...
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C-type lectin domain-containing protein CLEC3A regulates proliferation, regeneration and maintenance of nucleus pulposus cells
It is widely assumed that as connective tissue, the intervertebral disc (IVD) plays a crucial role in providing flexibility for the spinal column....
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Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration
BackgroundIntervertebral disc degeneration (IVDD) can cause low back pain, a major public health concern. IVDD is characterized with loss of cells...
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Mesenchymal Stem Cells as Modern Off-the-Shelf Products: From Research Perspectives to Clinical Practice
Mesenchymal stem cells (MSCs) are multipotent stem cells capable of differentiating into many cell types. They also have a remarkable ability to...
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Mesenchymal stem cells and their microenvironment
Mesenchymal stem cells (MSCs), coming from a wide range of sources, have multi-directional differentiation ability. MSCs play vital roles in...
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Extracellular matrix-induced signaling pathways in mesenchymal stem/stromal cells
The extracellular matrix (ECM) is a crucial component of the stem cell microenvironment, or stem-cell niches, and contributes to the regulation of...
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The functional effects of Piezo channels in mesenchymal stem cells
Mesenchymal stem cells (MSCs) are widely used in cell therapy, tissue engineering, and regenerative medicine because of their self-renewal,...
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Mesenchymal Stem Cells as Modern Off-the-Shelf Products: From Research Perspectives to Clinical Practice
Mesenchymal stem cells (MSCs) are multipotent stem cells capable of differentiating into many cell types. They also have a remarkable ability to...
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Induced pluripotent stem cell-derived mesenchymal stem cells deliver exogenous miR-105-5p via small extracellular vesicles to rejuvenate senescent nucleus pulposus cells and attenuate intervertebral disc degeneration
BackgroundMesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) have emerged as a promising new therapeutic strategy for...
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Menstrual blood-derived mesenchymal stem cells combined with collagen I gel as a regenerative therapeutic strategy for degenerated disc after discectomy in rats
BackgroundAnnulus fibrosis (AF) defects have been identified as the primary cause of disc herniation relapse and subsequent disc degeneration...
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Research progress of the application of mesenchymal stem cells in chronic inflammatory systemic diseases
Chronic inflammatory systemic diseases are the result of the body's immune imbalance, with a long course and recurring episodes. Immunosuppressants...
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Mesenchymal stem cells and their derived small extracellular vesicles for COVID-19 treatment
Since December 2019, the coronavirus (COVID-19) pandemic has imposed huge burdens to the whole world, seriously affecting global economic growth, and...
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FNDC5 inhibits autophagy of bone marrow mesenchymal stem cells and promotes their survival after transplantation by downregulating Sp1
Regenerative therapy based on mesenchymal stem cells (MSCs) has great promise to achieve functional recovery in cerebral infarction patients....
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Epitranscriptomic modifications in mesenchymal stem cell differentiation: advances, mechanistic insights, and beyond
RNA modifications, known as the “epitranscriptome”, represent a key layer of regulation that influences a wide array of biological processes in...
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microRNA-140-5p from human umbilical cord mesenchymal stem cells–released exosomes suppresses preeclampsia development
This work unraveled the action of human umbilical cord mesenchymal stem cells–released exosomes (huc-MSCs-EXO) transfer of miR-140-5p in preeclampsia...
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Analyzing the cellular and molecular atlas of ovarian mesenchymal cells provides a strategy against female reproductive aging
Ovarian mesenchymal cells (oMCs) constitute a distinct microenvironment that supports folliculogenesis under physiological conditions....
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Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway
The endogenous repair failure of degenerated intervertebral disk (IVD) is highly related to the exhaustion of nucleus pulposus stem cells (NPSCs)....
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Co‐culture with Sirt1-overexpressed chondrocytes delays the nucleus pulposus cells degeneration
Nucleus pulposus cells (NPCs) degeneration is an essential pathological basis of intervertebral disc diseases, and autologous cell transplantation is...
