Search
Search Results
-
Nuclear import receptors and hnRNPK mediates nuclear import and stress granule localization of SIRLOIN
The majority of lncRNAs and a small fraction of mRNAs localize in the cell nucleus to exert their functions. A SIRLOIN RNA motif was previously...
-
Nuclear import of Mas-related G protein-coupled receptor member D induces pathological cardiac remodeling
Alamandine (Ala), a ligand of Mas-related G protein-coupled receptor, member D (MrgD), alleviates angiotensin II (AngII)-induced cardiac hypertrophy....
-
The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD
Expanded intronic G 4 C 2 repeats in the C9ORF72 gene cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These intronic...
-
Nuclear import of PTPN18 inhibits breast cancer metastasis mediated by MVP and importin β2
Distant metastasis is the primary cause of breast cancer-associated death. The existing information, such as the precise molecular mechanisms and...
-
Chaperone proteins and peroxisomal protein import
Peroxisomes are ubiquitous organelles present in most eukaryotic cells. Their role in cellular metabolism is diverse among species. An array of genes...
-
Hormone-Inducible Transport Reporter Assay to Study Nuclear Import Defects in Neurodegenerative Diseases
In the recent years, defective nuclear import has emerged as an important pathomechanism of neurodegenerative diseases, particularly in amyotrophic...
-
Integration of FUNDC1-associated mitochondrial protein import and mitochondrial quality control contributes to TDP-43 degradation
Though TDP-43 protein can be translocated into mitochondria and causes mitochondrial damage in TDP-43 proteinopathy, little is known about how TDP-43...
-
A Simple Method for the Detection of Wybutosine-Modified tRNAPheGAA as a Readout of Retrograde tRNA Nuclear Import and Re-export: HCl/Aniline Cleavage and Nonradioactive Northern Hybridization
tRNAs are highly mobile molecules that are trafficked back and forth between the nucleus and cytoplasm by several proteins. However, characterization...
-
Identification of a nuclear localization signal mediating the nuclear import of Arabidopsis splicing factor1
The splicing factor1 protein (SF1) is involved in branch point recognition of pre-mRNA introns during the early stages of spliceosome assembly in the...
-
The LINC Complex Assists the Nuclear Import of Mechanosensitive Transcriptional Regulators
Mechanical forces play pivotal roles in directing cell functions and fate. To elicit gene expression, either intrinsic or extrinsic mechanical...
-
Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle
Effective protein import from cytosol is critical for mitochondrial functions and metabolic regulation. We describe here the mammalian...
-
Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway
Mitochondrial stress inducers such as carbonyl cyanide m-chlorophenyl hydrazone (CCCP) and oligomycin trigger the DELE1-HRI branch of the integrated...
-
Neddylation of PTEN regulates its nuclear import and promotes tumor development
PTEN tumor suppressor opposes the PI3K/Akt signaling pathway in the cytoplasm and maintains chromosomal integrity in the nucleus. Nucleus–cytoplasm...
-
Types of nuclear localization signals and mechanisms of protein import into the nucleus
Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the...
-
LASS2 enhances p53 protein stability and nuclear import to suppress liver cancer progression through interaction with MDM2/MDMX
LASS2 functions as a tumor suppressor in hepatocellular carcinoma (HCC), the most common type of primary liver cancer, but the underlying mechanism...
-
Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels
Delivering the virus genome into the host nucleus through the nuclear pore complex (NPC) is pivotal in human immunodeficiency virus 1 (HIV-1)...
-
Acyl CoA oxidase: from its expression, structure, folding, and import to its role in human health and disease
β-oxidation of fatty acids is an important metabolic pathway and is a shared function between mitochondria and peroxisomes in mammalian cells. On the...
-
BMP-1-induced GBA1 nuclear accumulation provokes CCN2 mRNA expression via importin-β-mediated nucleocytoplasmic pathway
Bone morphogenetic protein (BMP)-1 is expressed by odontoblasts in the dentin-pulp complex. Although the functional effects of BMP-1 on the...
-
Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT
Effective protein quality control (PQC), essential for cellular health, relies on spatial sequestration of misfolded proteins into defined...
-
A Cell-Free In Vitro Import System for Peroxisomal Proteins Containing a Type 2 Targeting Signal (PTS2)
Cell-free in vitro systems are invaluable tools to study the molecular mechanisms of protein translocation across biological membranes. We have been...