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Potent suppression of neuroendocrine tumors and gastrointestinal cancers by CDH17CAR T cells without toxicity to normal tissues
Gastrointestinal cancers (GICs) and neuroendocrine tumors (NETs) are often refractory to therapy after metastasis. Adoptive cell therapy using...
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Variation in Morpho-Agronomic Traits of Lowland Rice (Oryza Sativa) Genotypes of Assam in Response to Phosphorus Fertilization
The present investigation was conducted with twenty-four genotypes (sub-plot) in two phosphorus doses (main plot) in a split-plot design with three...
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Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury
The STING pathway and its induction of autophagy initiate a potent immune defense response upon the recognition of pathogenic DNA. However, this...
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IL-22 ameliorates LPS-induced acute liver injury by autophagy activation through ATF4-ATG7 signaling
Uncontrollable inflammatory response acts as a driver of sepsis-associated liver injury (SALI). IL-22 plays an important role in regulating...
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Field Experiment: Effects of Increased Temperature on a Tidalic Fluvisol
An experimental approach was executed in one salt marsh in western Schleswig-Holstein to analyse the reaction of soil processes under a 5°K higher...
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Soils
The soil units of all project research areas were described. Their functions as part of ecosystems are characterised by the properties of...
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Monthly and Seasonal Forecast of Precipitation and Temperature over India for Agro-meteorological Applications
Government, industry, traffic, media, farming community and risk management departments need a reliable high-resolution weather forecast (Majewski,...
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A conserved mechanism determines the activity of two pivotal transcription factors that control epidermal cell differentiation in Arabidopsis thaliana
The surface of plants is covered by the epidermis, which protects the plant’s body from the external environment and mediates inter-cell layer...
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Structure and function of the N-terminal extension of the formin INF2
In INF2—a formin linked to inherited renal and neurological disease in humans—the DID is preceded by a short N-terminal extension of unknown...
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Expression of virus-like particles (VLPs) of foot-and-mouth disease virus (FMDV) using Saccharomyces cerevisiae
AbstractWe engineered Saccharomyces cerevisiae to express structural proteins of foot-and-mouth disease virus (FMDV) and produce virus-like...
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Adenylate cyclase A amplification and functional diversification during Polyspondylium pallidum development
BackgroundIn Dictyostelium discoideum ( Ddis ), adenylate cyclase A (ACA) critically generates the cAMP oscillations that coordinate aggregation and...
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Gene Therapy
The gene with the expression vector is inserted in the organ, which needs to be repaired. The gene is expressed locally in the area and recombinant...
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Secrets and lies of host–microbial interactions: MHC restriction and trans-regulation of T cell trafficking conceal the role of microbial agents on the edge between health and multifactorial/complex diseases
Here we critically discuss data supporting the view that microbial agents (pathogens, pathobionts or commensals alike) play a relevant role in the...
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Golgi-Localized OsFPN1 is Involved in Co and Ni Transport and Their Detoxification in Rice
Cobalt (Co) and nickel (Ni) are beneficial and essential elements for plants, respectively, with the latter required for urease activity, which...
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Emerging roles for diguanylate cyclase during the evolution of soma in dictyostelia
BackgroundCyclic di-guanylate (c-di-GMP), synthesized by diguanylate cyclase, is a major second messenger in prokaryotes, where it triggers biofilm...
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OsCYBDOMG1, a cytochrome b561 domain-containing protein, regulates salt tolerance and grain yield in rice
Key messageOsCYBDOMG1 positively regulates salt tolerance, plant growth, and grain yield by affecting ascorbate biosynthesis and redox state.
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Identification of two plastid transit peptides for construction of pollen-inactivation system in rice
Hybrid seed production technology (SPT) is achieved through the utilization of a recessive nuclear male-sterile mutant transformed with a transgenic...
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Indexing heat stress induced changes in transgenic tobacco by overexpressing membrane-tethered transcription factor from Sorghum bicolor bZIP17
Basic leucine zipper (bZIP) TF family is key regulator of diverse biological functions, including heat stress tolerance. However, its role in...
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Rpn4p without the DNA-Binding Domain Provides Saccharomyces cerevisiae Resistance to Oxidative Stress and Cycloheximide
AbstractThe ubiquitin-proteasome system is involved in the control of all essential molecular processes under normal conditions and the response of...
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Comparative stability and analytical performance of anti-miroestrol recombinant antibody in different cassettes
Immunoassays are efficient for the phytochemical analysis of various matrices. However, producing an appropriate recombinant antibody for small...
