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Association of skeletal muscle oxidative capacity with muscle function, sarcopenia-related exercise performance, and intramuscular adipose tissue in older adults
Muscle function and exercise performance measures, such as muscle endurance capacity, maximal strength, chair stand score, gait speed, and Timed Up...
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Simulated microgravity attenuates myogenesis and contractile function of 3D engineered skeletal muscle tissues
While the effects of microgravity on inducing skeletal muscle atrophy have been extensively studied, the impacts of microgravity on myogenesis and...
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Methods to Monitor Circadian Clock Function in Skeletal Muscle
The circadian clock exerts temporal regulation in physiology and behavior. The skeletal muscle possesses cell-autonomous clock circuits that play key...
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Spaceflight effects on human vascular smooth muscle cell phenotype and function
The cardiovascular system is strongly impacted by the hazards of spaceflight. Astronauts spending steadily increasing lengths of time in microgravity...
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Network of muscle fibers activation facilitates inter-muscular coordination, adapts to fatigue and reflects muscle function
Fundamental movement patterns require continuous skeletal muscle coordination, where muscle fibers with different timing of activation synchronize...
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An updated C. elegans nuclear body muscle transcriptome for studies in muscle formation and function
The body muscle is an important tissue used in organisms for proper viability and locomotion. Although this tissue is generally well studied and...
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Tropomyosin 3 (TPM3) function in skeletal muscle and in myopathy
The tropomyosin genes ( TPM1-4 ) contribute to the functional diversity of skeletal muscle fibers. Since its discovery in 1988, the TPM3 gene has been...
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Determining the feasibility of characterising cellular senescence in human skeletal muscle and exploring associations with muscle morphology and physical function at different ages: findings from the MASS_Lifecourse Study
Cellular senescence may be associated with morphological changes in skeletal muscle and changes in physical function with age although there have...
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A potential correlation between adipokines, skeletal muscle function and bone mineral density in middle-aged and elderly individuals
BackgroundEvidence exists of a strong association between inflammation and a decrease in skeletal muscle function and bone mineral density (BMD);...
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O304 ameliorates hyperglycemia in mice by dually promoting muscle glucose effectiveness and preserving β-cell function
Although insulin mediated glucose uptake in skeletal muscle is a major mechanism ensuring glucose disposal in humans, glucose effectiveness, i.e.,...
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Absence of the primary cilia formation gene Talpid3 impairs muscle stem cell function
Skeletal muscle stem cells (MuSC) are crucial for tissue homoeostasis and repair after injury. Following activation, they proliferate to generate...
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Vitamin A regulates mitochondrial biogenesis and function through p38 MAPK-PGC-1α signaling pathway and alters the muscle fiber composition of sheep
BackgroundVitamin A (VA) and its metabolite, retinoic acid (RA), are of great interest for their wide range of physiological functions. However, the...
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Skeletal Muscle Receptors
This amazing chapter takes a deep dive into the realm of skeletal muscle receptors, particularly emphasizing the Vitamin D receptor (VDR) and the...
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Effects of weaning on intestinal longitudinal muscle-myenteric plexus function in piglets
Weaning piglets usually suffer from severe diarrhea (commonly known as postweaning diarrhea, PWD) along with intestinal motility disorder. Intestinal...
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Anti-RANKL Therapy Prevents Glucocorticoid-Induced Bone Loss and Promotes Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy
Bisphosphonates prevent bone loss in glucocorticoid (GC)-treated boys with Duchenne muscular dystrophy (DMD) and are recommended as standard of care....
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The Effects of Exercise on Skeletal Muscle
This chapter investigates the profound effects of exercise on skeletal muscle. In its many forms, exercise plays an indisputable role in influencing...
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Effect of Three Weeks of Strict Head‑Down Tilt Bed Rest on Human Muscle Function and Architecture
AbstractThe purpose of this study was, first, to quantitatively describe the relationship between joint angles and muscle architecture (length, fiber...
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Healthy aging and muscle function are positively associated with NAD+ abundance in humans
Skeletal muscle is greatly affected by aging, resulting in a loss of metabolic and physical function. However, the underlying molecular processes and...
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Use of a novel technique to assess impact of age-related denervation on mouse soleus muscle function
Denervation contributes to loss of force-generating capacity in aged skeletal muscles, but problems with quantification of denervated fibers mean the...
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Basic Structure of Skeletal Muscle
Building on the foundational understanding established in the first chapter, Chap. 2 explores the burgeoning...