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A murine monoclonal antibody against H5N1 avian influenza virus cross-reacts with human kidney cortex cells
To investigate the biological characteristics of monoclonal antibodies (mAbs) against avian influenza virus (AIV) and the possible mechanism of...
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Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases
Kidney diseases remain one of the leading causes of human death and have placed a heavy burden on the medical system. Regulated cell death...
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Dysregulated lipid metabolism is associated with kidney allograft fibrosis
BackgroundInterstitial fibrosis and tubular atrophy (IF/TA), a histologic feature of kidney allograft destruction, is linked to decreased allograft...
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INF2 formin variants linked to human inherited kidney disease reprogram the transcriptome, causing mitotic chaos and cell death
Mutations in the human INF2 gene cause autosomal dominant focal segmental glomerulosclerosis (FSGS)—a condition characterized by podocyte loss,...
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Modeling oxidative injury response in human kidney organoids
BackgroundHemolysis occurs in many injury settings and can trigger disease processes. In the kidney, extracellular hemoglobin can induce damage via...
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Hyaluronan in Kidney Fibrosis
The kidney is the organ responsible for the regulation of the body’s fluid balance. Hyaluronan (HA), because of its unique hydration capacity, is...
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Diabetic kidney disease induces transcriptome alterations associated with angiogenesis activity in human mesenchymal stromal cells
BackgroundTherapeutic interventions that optimize angiogenic activities may reduce rates of end-stage kidney disease, critical limb ischemia, and...
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Recellularization of Acellular Xeno Kidney Scaffold: An In Vivo Method to Generate Bioartificial Kidney
A significant hurdle for kidney tissue engineering is reproducing the complex three-dimensional structure of the kidney. In our study, a stepwise...
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HIF-1α promotes kidney organoid vascularization and applications in disease modeling
BackgroundKidney organoids derived from human pluripotent stem cells (HiPSCs) hold huge applications for drug screening, disease modeling, and cell...
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Human umbilical cord mesenchymal stem cell exosome-derived miR-874-3p targeting RIPK1/PGAM5 attenuates kidney tubular epithelial cell damage
BackgroundKidney insults due to various pathogenic factors, such as trauma, infection, and inflammation, can cause tubular epithelial cell injury and...
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Podocytes derived from human induced pluripotent stem cells: characterization, comparison, and modeling of diabetic kidney disease
BackgroundIn diabetic kidney disease, high glucose damages specialized cells called podocytes that filter blood in the glomerulus. In vitro culture...
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DeeP4med: deep learning for P4 medicine to predict normal and cancer transcriptome in multiple human tissues
BackgroundP4 medicine (predict, prevent, personalize, and participate) is a new approach to diagnosing and predicting diseases on a...
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Integrating spatial transcriptomics with single-cell transcriptomics reveals a spatiotemporal gene landscape of the human develo** kidney
BackgroundResearch on spatiotemporal gene landscape can provide insights into the spatial characteristics of human kidney development and facilitate...
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Effect of Protein Arginine Methyltransferase 1 Gene Knockout on the Proliferation of Human Embryonic Kidney 293T Cells
AbstractTo construct a protein arginine methyltransferase 1 (PRMT1) knockout human embryonic kidney cell line 293T (HEK293T/293T) and elucidate the...
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Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer
Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer in the adult population. Late diagnosis, resistance to therapeutics and...
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Isolation and Flow Cytometry Analysis of Macrophages from the Kidney
Renal macrophages help maintain homeostasis, participate in tissue injury and repair, and play a vital role in immune surveillance [1–3]. Kidney...
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Spermidine from arginine metabolism activates Nrf2 and inhibits kidney fibrosis
Kidney metabolism may be greatly altered in chronic kidney disease. Here we report that arginine metabolism is the most altered in unilateral...
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iPSC-derived type IV collagen α5-expressing kidney organoids model Alport syndrome
Alport syndrome (AS) is a hereditary glomerulonephritis caused by COL4A3 , COL4A4 or COL4A5 gene mutations and characterized by abnormalities of...
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Chronic Kidney Disease: Challenges in Translational Medicine
Chronic kidney disease (CKD) has long been recognized as a state of progressive decline in renal function. Morbidity and mortality are well...