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Mitigation of acute lung injury by human bronchial epithelial cell-derived extracellular vesicles via ANXA1-mediated FPR signaling
Acute lung injury (ALI) is characterized by respiratory failure resulting from the disruption of the epithelial and endothelial barriers as well as...
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DNA methylome analysis reveals potential alterations contributing to the progression of bronchial hyperplasia
BackgroundSquamous cell lung cancer (SCLC) arises from bronchial changes: basal cell hyperplasia (BCH), squamous metaplasia (SM), and dysplasia....
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Tyndallized bacteria prime bronchial epithelial cells to mount an effective innate immune response against infections
Airway epithelium represents a physical barrier against toxic substances and pathogens but also presents pattern recognition receptors on the...
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Anti-inflammatory and relaxation effects of Ulmus pumilla L. on EGF-inflamed bronchial epithelial and asthmatic bronchial smooth muscle cells
BackgroundUlmus Pumila L. (UPL), the roots of a tree species of elm, has been prescribed for immunity-related diseases, such as dermatitis,...
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Transcriptomic Response of Primary Human Bronchial Cells to Repeated Exposures of Cigarette and ENDS Preparations
Cigarette smoke deregulates several biological pathways by modulating gene expression in airway epithelial cells and altering the physiology of the...
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Lactobacillus rhamnosus Restores Antiviral Signaling and Attenuates Cytokines Secretion from Human Bronchial Epithelial Cells Exposed to Cigarette Smoke and Infected with SARS-CoV-2
Individuals with chronic obstructive pulmonary disease (COPD) are more susceptible to exacerbation crisis triggered by secondary lung infections due...
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Expandable Lung Epithelium Differentiated from Human Embryonic Stem Cells
BackgroundThe progenitors to lung airway epithelium that are capable of long-term propagation may represent an attractive source of cells for...
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MFG-E8 stabilized by deubiquitinase USP14 suppresses cigarette smoke-induced ferroptosis in bronchial epithelial cells
Milk fat globule epidermal growth factor 8 (MFG-E8) participates in a range of cellular processes, including reducing apoptosis and oxidative stress....
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Bronchial epithelial transcriptomics and experimental validation reveal asthma severity-related neutrophilc signatures and potential treatments
Airway epithelial transcriptome analysis of asthma patients with different severity was used to disentangle the immune infiltration mechanisms...
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Proliferation Genes Repressed by TGF-β Are Downstream of Slug/Snail2 in Normal Bronchial Epithelial Progenitors and Are Deregulated in COPD
Slug/Snail2 belongs to the Epithelial-Mesenchymal Transition (EMT)-inducing transcription factors involved in development and diseases. Slug is...
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BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma
BackgroundFine particulate matter (PM2.5) is associated with increased incidence and severity of asthma. PM2.5 exposure disrupts airway epithelial...
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Responsiveness of human bronchial fibroblasts and epithelial cells from asthmatic and non-asthmatic donors to the transforming growth factor-β1 in epithelial-mesenchymal trophic unit model
BackgroundThe asthma-related airway wall remodeling is associated i.a. with a damage of bronchial epithelium and subepithelial fibrosis. Functional...
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The Human Microbiome and Respiratory Diseases
The composition of the respiratory tract microbiota has been actively studied around the world. In this article, we have analyzed and summarized the...
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Role of STAT3 Transcription Factor in Pathogenesis of Bronchial Asthma
AbstractBronchial asthma is a heterogeneous chronic inflammatory disease of airways. The studies of molecular and cellular mechanisms of bronchial...
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Genes coding for transcription factors involved in stem cell maintenance are repressed by TGF-β and downstream of Slug/Snail2 in COPD bronchial epithelial progenitors
BackgroundBasal stem/progenitor cells of airway epithelium from chronic obstructive pulmonary disease (COPD) patients have a decrease in...
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Exosome-encapsulated lncRNA HOTAIRM1 contributes to PM2.5-aggravated COPD airway remodeling by enhancing myofibroblast differentiation
Emphysema, myofibroblast accumulation and airway remodeling can occur in the lungs due to exposure to atmospheric pollution, especially fine...
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Human alveolar progenitors generate dual lineage bronchioalveolar organoids
Mechanisms of epithelial renewal in the alveolar compartment remain incompletely understood. To this end, we aimed to characterize alveolar...
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Establishing Air-Liquid Interface (ALI) Airway Culture Models for Infectious Disease Research
Air-liquid interface (ALI) airway cultureAir-liquid interface (ALI) airway culture models serve as a powerful tool to emulate the characteristic...
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MicroRNA-629-3p Promotes Interleukin-13-Induced Bronchial Epithelial Cell Injury and Inflammation by Targeting FOXA2
ObjectiveAsthma is a chronic pulmonary inflammatory disease. MicroRNA (miR)-629-3p expression is reported to be up-regulated in the sputum of asthma...
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Effect of carbohydrates on the adhesion of Bordetella bronchiseptica to the respiratory epithelium in rabbits
This study proposes an ecological approach for preventing respiratory tract infections caused by Bordetella bronchiseptica in mammals using a mixture...
