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Mechanistic insights of Euphorbia milii des moul mediated biocompatible and non-cytotoxic, antimicrobial nanoparticles: an answer to multidrug resistant bacteria
The emergence of drug-resistant microbial pathogens is a matter of global concern and become more serious if they linked with healthcare-associated...
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Mechanistic and therapeutic perspectives of non-coding RNA-modulated apoptotic signaling in diabetic retinopathy
Diabetic retinopathy (DR), a significant and vision-endangering complication associated with diabetes mellitus, constitutes a substantial portion of...
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Explanation in Evo-Devo
Evo-devo is a multidisciplinary field that investigates the interplay between evolutionary and developmental processes and brings together different...
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Explanation in Evo-Devo
Evo-devo is a multidisciplinary field that investigates the interplay between evolutionary and developmental processes and brings together different...
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Theoretical Explanation for the Variability in Platelet Activation through the GPVI Receptor
Abstract—One of the key receptors on the surface of platelets, non-nuclear cells responsible for preventing blood loss when blood vessels are...
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Mechanistic study of regulation of iron homeostasis by N. sativa seeds and P. ovata husks on high fat/high sucrose diet induced non-alcoholic fatty liver disease
BackgroundIn recent years, nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions. Characteristic findings in NAFLD patients are...
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The Organism in Evolutionary Explanation: From Early Twentieth Century to the Extended Evolutionary Synthesis
In recent years there have been a number of calls for integrating developmental and organismal phenomena into evolutionary theory. This so-called...
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Like History, Evolution “Rhymes”
Since evolution is the biologic “history” of man, it should be functionally integrated with our social history. Furthermore, conventional Darwinian...
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Early manifestation of aging-related vascular dysfunction in human penile vasculature—A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease
Advanced age is related to functional alterations of human vasculature, but erectile dysfunction precedes systemic manifestations of vascular...
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Mechanistic interpretation of non-coding variants for discovering transcriptional regulators of drug response
BackgroundIdentification of functional non-coding variants and their mechanistic interpretation is a major challenge of modern genomics, especially...
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Mechanistic analysis of enhancer sequences in the estrogen receptor transcriptional program
Estrogen Receptor α (ERα) is a major lineage determining transcription factor (TF) in mammary gland development. Dysregulation of ERα-mediated...
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Genes that are Used Together are More Likely to be Fused Together in Evolution by Mutational Mechanisms: A Bioinformatic Test of the Used-Fused Hypothesis
Cases of parallel or recurrent gene fusions in evolution as well as in genetic disease and cancer are difficult to explain, because unlike point...
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Introduction
In this chapter, we make some general comments about the nature of scientific explanation and use them to contextualize recent debates within...
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Potential role of the lncRNA "HOTAIR"/miRNA "206"/BDNF network in the alteration in expression of synaptic plasticity gene arc and BDNF level in sera of patients with heroin use disorder through the PI3K/AKT/mTOR pathway compared to the controls
IntroductionHeroin use disorder (HUD) is a seriously increasing health issue, accounting for most deaths among drug abusers. Studying non-coding...
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Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication
Replication of viruses requires interaction with host cell factors and repression of innate immunity. Recent findings suggest that a subset of...
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Transcriptomic signatures of individual cell types in cerebral cavernous malformation
Cerebral cavernous malformation (CCM) is a hemorrhagic neurovascular disease with no currently available therapeutics. Prior evidence suggests that...
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Emerging functions within the enzyme families of plant alkaloid biosynthesis
The alkaloids are a major class of nitrogen-containing plant specialized metabolites that function as both toxic defense compounds and useful...
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Methods: Ways of Gaining Knowledge
Whether and to what extent the meaning content of natural phenomena is accessible to the exact sciences has long been a subject of controversy. At...
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Digital strategies for nitrogen management in grain production systems: lessons from multi-method assessment using on-farm experimentation
During the past few decades, a range of digital strategies for Nitrogen (N) management using various types of input data and recommendation...
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Climate drives global functional trait variation in lizards
A major challenge in ecology and evolution is to disentangle the mechanisms driving broad-scale variation in biological traits such as body size,...
