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Ectopic JAK–STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance
Emerging evidence indicates that various cancers can gain resistance to targeted therapies by acquiring lineage plasticity. Although various genomic...
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Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases
The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immunological processes, including cell...
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STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK–STAT endosomal activation
Activation of the JAK–STAT pathway by type I interferons (IFNs) requires clathrin-dependent endocytosis of the IFN-α and -β receptor (IFNAR),...
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WNT Signaling in Stem Cells: A Look into the Non-Canonical Pathway
Tissue homeostasis is crucial for multicellular organisms, wherein the loss of cells is compensated by generating new cells with the capacity for...
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Canonical and non-canonical functions of p53 isoforms: potentiating the complexity of tumor development and therapy resistance
Full-length p53 (p53α) plays a pivotal role in maintaining genomic integrity and preventing tumor development. Over the years, p53 was found to exist...
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Maheshvara regulates JAK/STAT signaling by interacting and stabilizing hopscotch transcripts which leads to apoptosis in Drosophila melanogaster
Maheshvara ( mahe ), an RNA helicase that is widely conserved across taxa, regulates Notch signaling and neuronal development in Drosophila . In order...
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The interaction between ferroptosis and inflammatory signaling pathways
Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation. Inflammation is one common and effective physiological...
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Comprehensive insight into altered host cell-signaling cascades upon Helicobacter pylori and Epstein–Barr virus infections in cancer
Cancer is characterized by mutagenic events that lead to disrupted cell signaling and cellular functions. It is one of the leading causes of death...
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Potential network markers and signaling pathways for B cells of COVID-19 based on single-cell condition-specific networks
To explore the potential network markers and related signaling pathways of human B cells infected by COVID-19, we performed standardized integration...
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Evidence for a non-canonical JAK/STAT signaling pathway in the synthesis of the brain’s major ion channels and neurotransmitter receptors
BackgroundBrain-derived neurotrophic factor (BDNF) is a major signaling molecule that the brain uses to control a vast network of intracellular...
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ROR1-STAT3 signaling contributes to ovarian cancer intra-tumor heterogeneity
Wnt pathway dysregulation through genetic and non-genetic alterations occurs in multiple cancers, including ovarian cancer (OC). The aberrant...
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The Cross-Talk between Epigenetic Gene Regulation and Signaling Pathways Regulates Cancer Pathogenesis
Cancer begins due to uncontrolled cell division. Cancer cells are insensitive to the signals that control normal cell proliferation. This...
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Medicinal chemistry perspective of JAK inhibitors: synthesis, biological profile, selectivity, and structure activity relationship
JAK-STAT signalling pathway was discovered more than quarter century ago. The JAK-STAT pathway protein is considered as one of the crucial hubs for...
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SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1
BackgroundSARS-CoV-2 is the causative agent of COVID-19. Overproduction and release of proinflammatory cytokines are the underlying cause of severe...
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Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses
Signaling cascades provide integrative and interactive frameworks that allow the cell to respond to signals from its environment and/or from within...
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Circadian patterns of growth factor receptor-dependent signaling and implications for carcinogenesis
Several different signaling pathways that regulate cell proliferation and differentiation are initiated by binding of ligands to cell-surface and...
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Integrative function of histone deacetylase 3 in inflammation
Inflammation is a complex biological response triggered when an organism encounters internal or external stimuli. These triggers activate various...
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NRN1 interacts with Notch to increase oncogenic STAT3 signaling in melanoma
BackgroundMelanoma is a highly heterogeneous cancer, in which frequent changes in activation of signaling pathways lead to a high adaptability to...
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NF-κB signaling in neoplastic transition from epithelial to mesenchymal phenotype
NF-κB transcription factors are critical regulators of innate and adaptive immunity and major mediators of inflammatory signaling. The NF-κB...
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Targeting Wnt/β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds
Wound healing is a tightly regulated process that ensures tissue repair and normal function following injury. It is modulated by activation of...
