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Nicotinamide Riboside Promotes the Proliferation of Endogenous Neural Stem Cells to Repair Spinal Cord Injury
AbstractActivation of endogenous neural stem cells (NSC) is one of the most potential measures for neural repair after spinal cord injury. However,...
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Morphology of Doxorubicin-Induced Organopathies under Different Intravenous Nicotinamide Riboside Administration Modes
AbstractDoxorubicin (DOX) is a potent chemotherapeutic drug, but its clinical use is hindered by significant side effects, it exerts on such vital...
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A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment
Nicotinamide riboside (NR) increases blood levels of NAD+, a cofactor central to energy metabolism, and improves brain function in some rodent models...
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Balancing NAD+ deficits with nicotinamide riboside: therapeutic possibilities and limitations
Alterations in cellular nicotinamide adenine dinucleotide (NAD + ) levels have been observed in multiple lifestyle and age-related medical conditions....
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Technology and functional insights into the nicotinamide mononucleotide for human health
AbstractNicotinamide mononucleotide (NMN), a naturally occurring biologically active nucleotide, mainly functions via mediating the biosynthesis of...
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Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study
The study evaluated how ingestion of nicotinamide mononucleotide (NMN) for 12 weeks by older adults affected blood nicotinamide adenine dinucleotide...
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Biological synthesis of nicotinamide mononucleotide
Nicotinamide mononucleotide (NMN) or Nicotinamide-1-ium-1-β-D-ribofuranoside 5′-phosphate is a nucleotide that can be converted into nicotinamide...
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Enhancing nicotinamide mononucleotide production from glucose in Escherichia coli by genetic engineering
Nicotinamide mononucleotide (NMN), as a healthcare product, plays positive effects on the human body. In this study, an engineered Escherichia coli ( E....
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Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid
Nicotinamide adenine dinucleotide (NAD + ) is crucial for energy metabolism, oxidative stress, DNA damage repair, longevity regulation, and several...
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The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions
Biosynthesis and regulation of nicotinamide adenine dinucleotide (NAD + ) has recently gained a lot of attention. A systemic decline in NAD + across...
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Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction
BackgroundHexose-6-Phosphate Dehydrogenase (H6PD) is a generator of NADPH in the Endoplasmic/Sarcoplasmic Reticulum (ER/SR). Interaction of H6PD with...
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Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity
The decline of nicotinamide adenine dinucleotide (NAD) occurs in a variety of human pathologies including neurodegeneration. NAD-boosting agents can...
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Complex roles of nicotinamide N-methyltransferase in cancer progression
Nicotinamide N -methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing the N-methylation of nicotinamide (NAM) to form...
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Nicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells
Nicotinamide, the amide form of Vitamin B3, is a common nutrient supplement that plays important role in human fetal development. Nicotinamide has...
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The Impact of Stimulation and Suppression of NAD+ Biosynthesis on the Maintenance of Pluripotency of Mouse Embryonic Stem Cells
AbstractNicotinamide adenine dinucleotide (NAD + ) plays a key role in cell metabolism and signaling. In recent years, evidence has accumulated that...
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Metabolism and Receptor Mechanisms of Niacin Action
AbstractThe paper discusses the metabolism of niacin, also known as vitamin B3 or PP, and the mechanisms of its receptor-induced functions in the...
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The role of NAD and NAD precursors on longevity and lifespan modulation in the budding yeast, Saccharomyces cerevisiae
Molecular causes of aging and longevity interventions have witnessed an upsurge in the last decade. The resurgent interests in the application of...
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The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy
Intervertebral disc degeneration (IVDD) is an aging disease that results in a low quality of life and heavy socioeconomic burden. The mitochondrial...
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WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome
BackgroundMetabolic dysfunction is one of the main symptoms of Werner syndrome (WS); however, the underlying mechanisms remain unclear. Here, we...
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NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury
Our understanding of how global changes in cellular metabolism contribute to human kidney disease remains incompletely understood. Here we show that...
