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The role of neutrophils in chronic cough
Chronic cough is a common disorder lasting more than 8 weeks and affecting all age groups. The evidence supporting the role of neutrophils in chronic...
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Neutrophils Are Atypical Antigen-Presenting Cells
AbstractNeutrophils are the most numerous blood leukocytes and are the “first line” of defense against pathogens in the focus of inflammation, where...
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Clearance of apoptotic cells by neutrophils in inflammation and cancer
When a cell dies of apoptosis, it is eliminated either by neighbouring cells or by attracted professional phagocytes. Although it was generally...
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Effect of Dexamethasone on Adhesion of Human Neutrophils and Concomitant Secretion
AbstractNeutrophils play a dual role in protecting the body. They are able to penetrate infected tissues and destroy pathogens there by releasing...
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Differential signalling requirements for RIPK1-dependent pyroptosis in neutrophils and macrophages
TLR4 and TNFR1 signalling promotes potent proinflammatory signal transduction events, thus, are often hijacked by pathogenic microorganisms. We...
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RIPK1 inhibitor ameliorates pulmonary injury by modulating the function of neutrophils and vascular endothelial cells
Acute lung injury (ALI) is an acute and progressive hypoxic respiratory failure that could progress to acute respiratory distress syndrome (ARDS)...
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Sex-specific circulating unconventional neutrophils determine immunological outcome of auto-inflammatory Behçet’s uveitis
Neutrophils are the most abundant immune cells that first respond to insults in circulation. Although associative evidence suggests that differences...
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Mesenchymal stem cells shift the pro-inflammatory phenotype of neutrophils to ameliorate acute lung injury
BackgroundMesenchymal stem cell (MSC) treatment plays a major role in the management of acute lung injury (ALI), and neutrophils are the initial line...
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Effect of Nanodispersions with Lipoic Acid and Its Esters on the Functional Activity of Neutrophils and Platelets
AbstractThe effect of nanodispersions with lipoic acid and its esters on the activity of lactate dehydrogenase in neutrophils and platelets has been...
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Self-recruited neutrophils trigger over-activated innate immune response and phenotypic change of cardiomyocytes in fulminant viral myocarditis
Fulminant myocarditis (FM) is a life-threatening inflammatory disease. However, the mechanisms underlying its acute onset are unknown. By dynamic...
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Mechanisms underlying neutrophils adhesion to triple-negative breast cancer cells via CD11b-ICAM1 in promoting breast cancer progression
BackgroundTriple-negative breast cancer (TNBC) is recognized as the most aggressive and immunologically infiltrated subtype of breast cancer. A high...
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Glycolytic neutrophils accrued in the spleen compromise anti-tumour T cell immunity in breast cancer
The coordination of immunity across organs is fundamental to cancer development and progression. It is well known that the hostile metabolic...
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Peripheral monocytes and neutrophils promote photoreceptor cell death in an experimental retinal detachment model
Photoreceptor cell death and immune cell infiltration are two major events that contribute to retinal degeneration. However, the relationship between...
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The effect of local anaesthetics on apoptosis and NETosis of human neutrophils in vitro: comparison between lidocaine and ropivacaine
There are immunological consequences to the method by which neutrophils undergo cell death. Neutrophil apoptosis, called silent death, leads to the...
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Bovine neutrophils kill the sexually-transmitted parasite Tritrichomonas foetus using trogocytosis
The protozoan parasite Tritrichomonas foetus ( T. foetus ) is the causative organism of bovine trichomonosis (also referred to as trichomoniasis), a...
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Human blood neutrophils generate ROS through FcγR-signaling to mediate protection against febrile P. falciparum malaria
Blood phagocytes, such as neutrophils and monocytes, generate reactive oxygen species (ROS) as a part of host defense response against infections. We...
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S100A8/A9hi neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis
S100a8/a9, largely released by polymorphonuclear neutrophils (PMNs), belongs to the S100 family of calcium-binding proteins and plays a role in a...
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Senescent neutrophils-derived exosomal piRNA-17560 promotes chemoresistance and EMT of breast cancer via FTO-mediated m6A demethylation
Cellular senescence is characterized by a tumor-suppressive program as well as a pro-inflammatory secretome. Neutrophils constitute significant...
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Genes regulating oxidative-inflammatory response in circulating monocytes and neutrophils in septic syndrome
Despite significant progress in the past decades, sepsis still lacks a specific treatment. Under normal conditions, leucocytes play a critical role...
