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Review of neurotoxicity of T-2 toxin
T-2 toxin is a representative trichothecene that is widely detected in corn, wheat and other grain feeds. T-2 toxin has stable physical and chemical...
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HDAC3 deacetylates H3K27ac and H3K9ac on the TrkC promoter to exacerbate sevoflurane-induced neurotoxicity
BackgroundSevoflurane (Sev) is a widely used general anesthetic that can cause neurotoxicity. Histone acetylation is a vital epigenetic mechanism...
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Intestinal microbiota protects against methylmercury-induced neurotoxicity
Methylmercury (MeHg) remains a global public health issue because of its frequent presence in human food sources obtained from the water. The...
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Quetiapine attenuates cadmium neurotoxicity by suppressing oxidative stress, inflammation, and pyroptosis
BackgroundCadmium (Cd) is a heavy metal with extremely harmful toxic effects on the brain. Quetiapine (QTP) has unique neuroprotective effects with...
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Crocin alleviates neurotoxicity induced by bupivacaine in SH-SY5Y cells with inhibition of PI3K/AKT signaling
BackgroundBupivacaine, a common local anesthetic, can cause neurotoxicity and permanent neurological disorders. Crocin has been widely reported as a...
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Complement C1q-mediated microglial synaptic elimination by enhancing desialylation underlies sevoflurane-induced developmental neurotoxicity
BackgroundRepeated neonatal sevoflurane exposures led to neurocognitive disorders in young mice. We aimed to assess the role of microglia and...
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Sodium Butyrate Ameliorates Fluorosis-Induced Neurotoxicity by Regulating Hippocampal Glycolysis In Vivo
Fluorosis can induce neurotoxicity. Sodium butyrate (SB), a histone deacetylase inhibitor, has important research potential in correcting glucose...
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STAMP2 alleviates microglial neurotoxicity by inhibiting LPS-induced NF-κB activation
BackgroundThe six-transmembrane protein of the prostate 2 (STAMP2) is crucial for damage-induced inflammation. Excessive inflammatory responses in...
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Melatonin Protects Against Titanium Oxide-Induced Neurotoxicity: Neurochemical, Neurobehavioral, and Histopathological Evidences
titania (titanium dioxide, TiO 2 ) is known to induce neurotoxicity and CNS dysfunctions. Numerous studies have explored the neuroprotective effects of...
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Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo
According to The World Alzheimer Report 2023 by Alzheimer’s Disease International (ADI) estimates that 33 to 38.5 million people worldwide suffer...
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Sulbactam protects neurons against double neurotoxicity of amyloid beta and glutamate load by upregulating glial glutamate transporter 1
Amyloid beta (Abeta) synergistically enhances excitotoxicity of glutamate load by impairing glutamate transporter 1 (GLT1) expression and function,...
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Melatonin Attenuates Arsenic-Induced Neurotoxicity in Rats Through the Regulation of miR-34a/miR-144 in Sirt1/Nrf2 Pathway
Arsenic (As) exposure is known to cause several neurological disorders through various molecular mechanisms such as oxidative stress, apoptosis, and...
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Alpha-mangostin Protects PC12 Cells Against Neurotoxicity Induced by Cadmium and Arsenic
Arsenic and cadmium are nonessential elements that are of importance in public health due to their high toxicity. Contact with these toxic elements,...
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Excessive Lysosomal Stress Response and Consequently Impaired Autophagy Contribute to Fluoride-Induced Developmental Neurotoxicity
Fluoride can cause developmental neurotoxicity; however, the precise mechanism has yet to be determined. We aimed to explore the possible role and...
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Pre-mating exposure with hesperidin protects N-ethyl-N-nitrosourea-induced neurotoxicity and congenital abnormalities in next generation of mice as a model of glioma
Chemical carcinogen-induced oxidative stress has a key role in cell signaling linked to the development of cancer. Oxidative stress leads to...
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Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome
Cancer immunotherapy with chimeric antigen receptor (CAR) T cells can cause immune effector cell-associated neurotoxicity syndrome (ICANS). However,...
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Loss of TDP-43 mediates severe neurotoxicity by suppressing PJA1 gene transcription in the monkey brain
The nuclear loss and cytoplasmic accumulation of TDP-43 (TAR DNA/RNA binding protein 43) are pathological hallmarks of amyotrophic lateral sclerosis...
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Regulation of BDNF transcription by Nrf2 and MeCP2 ameliorates MPTP-induced neurotoxicity
Mounting evidence suggests the key role of brain-derived neurotrophic factor (BDNF) in the dopaminergic neurotoxicity of Parkinson’s disease (PD)....
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Pluripotent Stem Cell-derived Dopaminergic Neurons for Studying Developmental Neurotoxicity
With the vast number of chemicals in commerce, higher throughput strategies are needed to inform risk assessment. The field of toxicology is...
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Fenpropathrin exposure induces neurotoxicity in zebrafish embryos
Fenpropathrin has been a commonly used insecticide to control agricultural and household insects over a few decades. Up to now, fenpropathrin residue...
