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Ex Vivo Model of Spontaneous Neuroretinal Degeneration for Evaluating Stem Cells’ Paracrine Properties
Ex vivo neuroretina cultures closely resemble in vivo conditions, retaining the complex neuroretina cells dynamics, connections, and functionality,...
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Factors influencing mesenchymal stromal cells in in vitro cellular models to study retinal pigment epithelial cell rescue
Mesenchymal stromal cells (MSC) stop or slow retinal pigment epithelium (RPE) and neuroretina (NR) degeneration by paracrine activity in oxidative...
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mTOR-dependent dysregulation of autophagy contributes to the retinal ganglion cell loss in streptozotocin-induced diabetic retinopathy
BackgroundNeurodegeneration, an early event in the pathogenesis of diabetic retinopathy (DR), precedes clinically detectable microvascular damage....
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All-trans retinoic acid modulates pigmentation, neuroretinal maturation, and corneal transparency in human multiocular organoids
BackgroundAll-trans retinoic acid (ATRA) plays an essential role during human eye development, being temporally and spatially adjusted to create...
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Application of Human Stem Cell Derived Retinal Organoids in the Exploration of the Mechanisms of Early Retinal Development
The intricate neural circuit of retina extracts salient features of the natural world and forms bioelectric impulse as the origin of vision. The...
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Evaluation of the State of the Blood-Retinal Barrier during the Development of Signs of Age-Related Macular Degeneration in OXYS Rats
AbstractAge-related macular degeneration (AMD) is a multifactorial neurodegenerative disease that is becoming the leading cause of irreversible...
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Intravitreal allogeneic mesenchymal stem cells: a non-randomized phase II clinical trial for acute non-arteritic optic neuropathy
BackgroundAn effective treatment for acute non-arteritic ischemic optic neuropathy (NA-AION) has not been known or proven yet. Previous studies have...
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Long-term intake of Lactobacillus helveticus enhances bioavailability of omega-3 fatty acids in the mouse retina
Omega-3 (n-3) polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), are required for the structure and function of the...
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Advances in cell therapies using stem cells/progenitors as a novel approach for neurovascular repair of the diabetic retina
BackgroundDiabetic retinopathy, a major complication of diabetes mellitus, is a leading cause of sigh-loss in working age adults. Progressive loss of...
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Astrocyte derived TSP2 contributes to synaptic alteration and visual dysfunction in retinal ischemia/reperfusion injury
BackgroundDespite current intervention measures/therapies are able to ameliorate neuronal death following retinal injuries/diseases, the recovery of...
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Macrophages modulate fibrosis during newt lens regeneration
BackgroundPrevious studies have suggested that macrophages are present during lens regeneration in newts, but their role in the process is yet to be...
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Transplantation of retinal pigment epithelium and photoreceptors generated concomitantly via small molecule-mediated differentiation rescues visual function in rodent models of retinal degeneration
BackgroundAge-related macular degeneration (AMD) is a result of degeneration/damage of the retinal pigment epithelium (RPE) while retinitis...
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Multiocular organoids from human induced pluripotent stem cells displayed retinal, corneal, and retinal pigment epithelium lineages
BackgroundRecently, great efforts have been made to design protocols for obtaining ocular cells from human stem cells to model diseases or for...
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Uveitic glaucoma-like features in Yap conditional knockout mice
Glaucoma is a multifactorial neurodegenerative disease characterized by the progressive and irreversible degeneration of the optic nerve and retinal...
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Ophthalmology of Agnatha: Lampreys and Hagfish
Clearly, the earliest eyes existed well before the development of the vertebrate body, but it is the jawless fish, the Agnathi, which provide us with...
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Persistent intraocular Ebola virus RNA is associated with severe uveitis in a convalescent rhesus monkey
Despite increasing evidence that uveitis is common and consequential in survivors of Ebola virus disease (EVD), the host-pathogen determinants of the...
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CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety
High myopia is a leading cause of blindness worldwide. It may lead to emotional defects that rely closely on the link between visual sensation and...
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Therapeutic Applications of Oxysterols and Derivatives in Age-Related Diseases, Infectious and Inflammatory Diseases, and Cancers
Oxysterols, resulting from the oxidation of cholesterol, are formed either by autoxidation, enzymatically, or by both processes. These molecules,...
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Stem cell therapy for inherited retinal diseases: a systematic review and meta-analysis
PurposeStem cell therapy is a promising therapeutic approach for inherited retinal diseases (IRDs). This study aims to quantitatively examine the...
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Paracrine effects of intraocularly implanted cells on degenerating retinas in mice
BackgroundRetinal degeneration is a leading cause of blindness in the world; its etiology is complex and involves genetic defects and...
