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An intestinal sphingolipid confers intergenerational neuroprotection
In animals, maternal diet and environment can influence the health of offspring. Whether and how maternal dietary choice impacts the nervous system...
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Molecular targets of histone deacetylase inhibitors in neurodegeneration and neuroprotection
BackgroundNeurodegenerative diseases show various phenotypes of molecular and cellular malfunction including mitochondrial dysfunction and...
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Enhanced mitochondrial biogenesis promotes neuroprotection in human pluripotent stem cell derived retinal ganglion cells
Mitochondrial dysfunctions are widely afflicted in central nervous system (CNS) disorders with minimal understanding on how to improve mitochondrial...
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Recent advances to Neuroprotection: repurposing drugs against neuroinflammatory disorders
Cell death is a natural mechanism for biological clearance for the maintenance of homeostasis in a dynamic microenvironment of the central nervous...
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Pro-survival Phenotype of HIF-1α: Neuroprotection Through Inflammatory Mechanisms
Hypoxia-inducible factor 1 (HIF-1) is a major player in the oxygen sensor system as well as a transcription factor. HIF-1 is also associated in the...
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Synergistic neuroprotection by phytocompounds of Bacopa monnieri in scopolamine-induced Alzheimer’s disease mice model
BackgroundMillions of people around the globe are affected by Alzheimer’s disease (AD). This crippling condition has no treatment despite intensive...
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Neuroprotection and axon regeneration by novel low-molecular-weight compounds through the modification of DOCK3 conformation
Dedicator of cytokinesis 3 (DOCK3) is an atypical member of the guanine nucleotide exchange factors (GEFs) and plays important roles in neurite...
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Human Wharton’s Jelly Mesenchymal Stem Cell Secretome Modifies the Processes of Neuroprotection and Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium at Transcriptional Level
BackgroundRetinal pigment epithelium (RPE) cells are potential targets for treating retinal detachment (RD) and proliferative vitreoretinopathy...
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Karan**: a potential furanoflavonoid for neuroprotection
Phytochemicals are widely known for the pharmacological effects in treating various human conditions and in recent years, new compounds are being...
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Hesperidin Supplementation During Alternate Day Fasting Provides Synergistic Effect in Conferring Neuroprotection to Aging Rats
Alternate day fasting (ADF) is a beneficial dietary intervention that reduces age- associated complications. Hesperidin is a potential antioxidant...
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Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection
Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced...
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Cellular prion protein offers neuroprotection in astrocytes submitted to amyloid β oligomer toxicity
The cellular prion protein (PrP C ), in its native conformation, performs numerous cellular and cognitive functions in brain tissue. However, despite...
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3-Bromopyruvate, a caloric restriction mimetic, exerts a mitohormetic effect to provide neuroprotection through activation of autophagy in rats during aging
In the present study, attempts have been made to evaluate the potential role of 3 Bromopyruvate (3-BP) a glycolytic inhibitor and a caloric...
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Neuroprotection by tetramethylpyrazine and its synthesized analogues for central nervous system diseases: a review
BackgroundDue to the global increase in aging populations and changes in modern lifestyles, the prevalence of neurodegenerative diseases,...
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Microglia and Stem-Cell Mediated Neuroprotection after Neonatal Hypoxia-Ischemia
Neonatal hypoxia-ischemia encephalopathy (HIE) refers to a brain injury in term infants that can lead to death or lifelong neurological deficits such...
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Molecular mechanisms underlying cyclophosphamide-induced cognitive impairment and strategies for neuroprotection in preclinical models
Cyclophosphamide has drastically enhanced the expectancy and quality of life of cancer patients. However, it is accompanied by diverse neurological...
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Molecular mechanism of caloric restriction mimetics-mediated neuroprotection of age-related neurodegenerative diseases: an emerging therapeutic approach
Aging-induced neurodegenerative diseases (NDs) are significantly increasing health problem worldwide. It has been well documented that oxidative...
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The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke
Remote limb ischemic postconditioning (RLIP) is an experimental strategy in which short femoral artery ischemia reduces brain damage induced by a...
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Multi-omics reveal neuroprotection of Acer truncatum Bunge Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude
Hypoxic-ischemic encephalopathy (HIE) at high-altitudes leads to neonatal mortality and long-term neurological complications without effective...
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GardeninA confers neuroprotection against environmental toxin in a Drosophila model of Parkinson’s disease
Parkinson’s disease is an age-associated neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons from the midbrain....
