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Hippocampal neurons code individual episodic memories in humans
The hippocampus is an essential hub for episodic memory processing. However, how human hippocampal single neurons code multi-element associations...
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BNST GABAergic neurons modulate wakefulness over sleep and anesthesia
The neural circuits underlying sleep-wakefulness and general anesthesia have not been fully investigated. The GABAergic neurons in the bed nucleus of...
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Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke
Neuronal ferroptosis plays a key role in neurologic deficits post intracerebral hemorrhage (ICH). However, the endogenous regulation of rescuing...
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Calcium-permeable AMPA and kainate receptors of GABAergic neurons
This Commentary presents a brief discussion of the action of glutamate calcium permeable receptors present with neurons on the release of the...
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Activation of oxytocinergic neurons enhances torpor in mice
Mus musculus enters a torpid state in response to caloric restriction in sub-thermoneutral ambient temperatures. This torpid state is characterized...
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NeuN Expression in Spinal Neurons Projecting to the Cerebellum
AbstractWe studied the distinctive features of NeuN immunolabeling in the neurons located in the four cat spinal cord structures sending projections...
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TMEM63B channel is the osmosensor required for thirst drive of interoceptive neurons
Thirst plays a vital role in the regulation of body fluid homeostasis and if deregulated can be life-threatening. Interoceptive neurons in the...
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Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
Central norepinephrine (NE) neurons, located mainly in the locus coeruleus (LC), are implicated in diverse psychiatric and neurodegenerative diseases...
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Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism
Agouti-related peptide (AgRP)-expressing and proopiomelanocortin (POMC)-expressing neurons reciprocally regulate food intake. Here, we combine...
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Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA
The lateral hypothalamic area (LHA) regulates food intake and energy balance. Although LHA neurons innervate adipose tissues, the identity of neurons...
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CaMK1D signalling in AgRP neurons promotes ghrelin-mediated food intake
Hypothalamic AgRP/NPY neurons are key players in the control of feeding behaviour. Ghrelin, a major orexigenic hormone, activates AgRP/NPY neurons to...
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Postprandial sodium sensing by enteric neurons in Drosophila
Sodium is essential for all living organisms
1 . Animals including insects and mammals detect sodium primarily through peripheral taste cells2 –7 . It is...
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nNOS in Erbb4-positive neurons regulates GABAergic transmission in mouse hippocampus
Neuronal nitric oxide synthase (nNOS, gene name Nos1) orchestrates the synthesis of nitric oxide (NO) within neurons, pivotal for diverse neural...
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USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neurons
Ubiquitination of mitochondrial proteins plays an important role in the cellular regulation of mitophagy. The E3 ubiquitin ligase parkin (encoded by PARK2...
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Comparative Neuroanatomy of Descending Neurons in Supraesophageal Ganglia of Cockroaches of the Family Blaberidae
AbstractHere, we report the results of the morphological investigation of descending neurons connecting the supraesophageal and thoracic ganglia in...
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Hypothalamic supramammillary neurons that project to the medial septum modulate wakefulness in mice
The hypothalamic supramammillary nucleus (SuM) plays a crucial role in controlling wakefulness, but the downstream target regions participating in...
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The Janus face of endogenous neuronal tPA: promoting self-protection and worsening the death of neighboring neurons
Recombinant tissue-type plasminogen activator (r-tPA/Actilyse) stands as the prevailing pharmacological solution for treating ischemic stroke...
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DNA Instability in Neurons: Lifespan Clock and Driver of Evolution
AbstractIn the last ten years, the discovery of neuronal DNA postmitotic instability has changed the theoretical landscape in neuroscience and, more...
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Upper brainstem cholinergic neurons project to ascending and descending circuits
BackgroundBased on their anatomical location, rostral projections of nuclei are classified as ascending circuits, while caudal projections are...
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Survival of compromised adult sensory neurons involves macrovesicular formation
Adult neurons are recognized as post-mitotically arrested cells with limited regenerative potential. Given these restraints, it is perplexing how...
