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In Vitro Simulated Neuronal Environmental Conditions Qualify Umbilical Cord Derived Highly Potent Stem Cells for Neuronal Differentiation
The healing of neuronal injuries is still an unachieved goal. Medicine-based therapies can only extend the survival of patients, but not finally lead...
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Adult hair follicle stem cells differentiate into neuronal cells in explanted rat intestinal tissue
Hair follicle stem cells (HFSCs) are adult stem cells located in the outer root sheath of the follicle bulge with high neural plasticity, which...
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From compartments to loops: understanding the unique chromatin organization in neuronal cells
The three-dimensional organization of the genome plays a central role in the regulation of cellular functions, particularly in the human brain. This...
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Retinoic Acid-Mediated Differentiation of Mouse Embryonic Stem Cells to Neuronal Cells
The capability of pluripotent embryonic stem cells (ESCs) to proliferate and differentiate into specific lineages makes them an important avenue of...
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PGC-1a mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration
Neurodegenerative disorders are characterized by the progressive loss of structure and function of neurons, often including the death of the neuron....
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PLCβ1 by-passes early growth response -1 to induce the differentiation of neuronal cells
The Gα q /phospholipase C-β (PLCβ) signaling system mediates calcium responses to a variety of hormones and neurotransmitters. Recent studies suggest...
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The HSP40 family chaperone isoform DNAJB6b prevents neuronal cells from tau aggregation
BackgroundAlzheimer’s disease (AD) is the most common neurodegenerative disorder with clinical presentations of progressive cognitive and memory...
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SUMOylation of nuclear receptor Nor1/NR4A3 coordinates microtubule cytoskeletal dynamics and stability in neuronal cells
BackgroundNor1/NR4A3 is a member of the NR4A subfamily of nuclear receptors that play essential roles in regulating gene expression related to...
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Hyaluronan-CD44 Interaction Regulates Mouse Retinal Progenitor Cells Migration, Proliferation and Neuronal Differentiation
Cell-based therapies have shown great potential because of their abilities to replace dying retinal neuron cells and preserve vision. The migration,...
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Neuronal and Muscle Differentiation of Mammalian Cells Is Accompanied by a Change in PHF10 Isoform Expression
AbstractThe PBAF chromatin remodeling complex of the SWI/SNF family plays a critical role in the regulation of gene expression during tissue...
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Tunnelling nanotubes between neuronal and microglial cells allow bi-directional transfer of α-Synuclein and mitochondria
Tunnelling Nanotubes (TNTs) facilitate contact-mediated intercellular communication over long distances. Material transfer via TNTs can range from...
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Thermal proteome profiling unveils protein targets of deoxycholic acid in living neuronal cells
Bile acids, synthesized in the liver and modified by the gut microbiota, play vital roles in various physiological processes. The dysregulation of...
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FMRP-mediated spatial regulation of physiologic NMD targets in neuronal cells
In non-polarized cells, nonsense-mediated mRNA decay (NMD) generally begins during the translation of newly synthesized mRNAs after the mRNAs are...
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Formononetin ameliorates the LPS-induced inflammatory response and apoptosis of neuronal cells via NF-κB/NLRP3 signaling pathway
The objective of this study was to investigate the impact of formononetin on cellular apoptosis and inflammatory responses following spinal cord...
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Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation
BackgroundNeural stem cells (NSCs) are considered as candidates for cell replacement therapy in many neurological disorders. However, the propensity...
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Fucoidan ameliorates amyloid-β 42 oligomer-induced neuronal apoptosis by activating the PI3K/Akt signaling pathway and MAPK cascades in human neuroblastoma SH-SY5Y cells
BackgroundFucoidan, a polysaccharide derived from brown seaweed, has multiple biological properties, including antioxidant, antitumor, anticoagulant,...
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Electrical pulse stimulation parameters modulate N2a neuronal differentiation
Electrical pulse stimulation has been used to enhance the differentiation or proliferation of neuronal progenitor cells in tissue engineering and...
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HSP70 attenuates neuronal necroptosis through the HSP90α-RIPK3 pathway following neuronal trauma
BackgroundNecroptosis, a newly defined regulatable necrosis with membrane disruption, has been demonstrated to participate in trauma brain injury...
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Non-Neuronal GABA in Neocortical Neurografts of the Rats
AbstractGamma aminobutyric acid (GABA) plays an important role in regulating the development and functioning of the brain. The aim of this work was...
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Neuronal autosis is Na+/K+-ATPase alpha 3-dependent and involved in hypoxic-ischemic neuronal death
Macroautophagy (hereafter called autophagy) is an essential physiological process of degradation of organelles and long-lived proteins. The discovery...
