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Pathological mechanisms of neuroimmune response and multitarget disease-modifying therapies of mesenchymal stem cells in Parkinson’s disease
Parkinson's disease (PD) is a neurodegenerative disease characterized by the degeneration of dopaminergic neurons in the substantia nigra (SN); the...
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PD-L1/PD-1 pathway: a potential neuroimmune target for pain relief
Pain is a common symptom of many diseases with a high incidence rate. Clinically, drug treatment, as the main method to relieve pain at present, is...
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Human parasagittal dura is a potential neuroimmune interface
Parasagittal dura (PSD) is located on both sides of the superior sagittal sinus and harbours arachnoid granulations and lymphatic vessels. Efflux of...
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A sex-stratified analysis of neuroimmune gene expression signatures in Alzheimer’s disease brains
Alzheimer’s disease (AD) is the most common form of progressively disabling dementia. The chitinases CHI3L1 and CHI3L2 have long been known as...
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The path to next-generation disease-modifying immunomodulatory combination therapies in Alzheimer’s disease
The cautious optimism following recent anti-amyloid therapeutic trials for Alzheimer’s disease (AD) provides a glimmer of hope after years of...
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Arsenic Activates the NLRP3 Inflammasome and Disturbs the Th1/Th2/Th17/Treg Balance in the Hippocampus in Mice
Arsenic exerts neurotoxicity and immunomodulatory effects. Studies have shown that the nervous system is not considered to be an immune-privileged...
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Non-Specific Targets for Correction of Pneumonia Caused by Aerosols Containing Damaging Factors of Various Nature
AbstractThis review article provides data on the current state of the pathogenesis peculiarities of body and lung inflammation (pneumonia) under the...
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The CSF1-CSF1R pathway in the trigeminal ganglion mediates trigeminal neuralgia via inflammatory responses in mice
BackgroundTrigeminal neuralgia (TN) is the most severe type of neuropathic pain. The trigeminal ganglion (TG) is a crucial target for the...
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From Peptides to Receptors
Abstract—In the 1960s and 1970s, the Institute of Chemistry of Natural Compounds developed a topochemical approach for designing new biologically...
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Pharmacological modulation of cytokines correlating neuroinflammatory cascades in epileptogenesis
Epileptic seizure-induced brain injuries include activation of neuroimmune response with activation of microglia, astrocytes cells releasing...
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Dietary Modulation of the Nervous and Immune System: Role of Probiotics/Prebiotics/Synbiotics/Postbiotics
The gut microbiota involves billions of microbial residents that live in the gastrointestinal tract. Gut microbiota is interconnected with multiple...
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Common immunopathogenesis of central nervous system diseases: the protein-homeostasis-system hypothesis
There are hundreds of central nervous system (CNS) diseases, but there are few diseases for which the etiology or pathogenesis is understood as well...
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Arsenic Induces Blood‒Brain Barrier Disruption and Regulates T Lymphocyte Subpopulation Differentiation in the Cerebral Cortex and Hippocampus Associated with the Nrf2 Pathway In Vivo
Increasing evidence has confirmed that the nervous system shows innate and adaptive immunity, which also participates in nerve damage. This study...
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Understanding the development, pathogenesis, and injury response of meningeal lymphatic networks through the use of animal models
Meningeal lymphatic vessels (MLVs) help maintain central nervous system (CNS) homeostasis via their ability to facilitate macromolecule waste...
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SNP-based and haplotype-based genome-wide association on drug dependence in Han Chinese
BackgroundDrug addiction is a serious problem worldwide and is influenced by genetic factors. The present study aimed to investigate the association...
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Cerebral endothelial cell-derived extracellular vesicles regulate microglial polarization and promote autophagy via delivery of miR-672-5p
The interaction between cerebral endothelial cells (CEC) and brain parenchymal cells is critical to maintain neurovascular homeostasis, whereas...
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Correction of Immunological and Behavioral Parameters in Rats with Experimental Traumatic Brain Injury by a Monoclonal Antibody to Complement Component 3
AbstractAfter traumatic brain injury (TBI), inflammation develops in the CNS, an active participant of which is the complement system. Activated...
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Peripheral NOD-like receptor deficient inflammatory macrophages trigger neutrophil infiltration into the brain disrupting daytime locomotion
Inflammation is known to disrupt normal behavior, yet the underlying neuroimmune interactions remain elusive. Here, we investigated whether...
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Lactoferrin deficiency during lactation increases the risk of depressive-like behavior in adult mice
BackgroundLactoferrin is an active protein in breast milk that plays an important role in the growth and development of infants and is implicated as...
