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DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation
As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early mammalian development, they acquire high DNA methylation...
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Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury
BackgroundVascular endothelial cells are pivotal in the pathophysiological progression following spinal cord injury (SCI). The UTX (Ubiquitously...
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Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression
Neural stem cells (NSCs) are critical for brain development and maintenance of neurogenesis. However, the molecular mechanisms that regulate NSC...
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Loss of Dip2b leads to abnormal neural differentiation from mESCs
BackgroundDisco-interacting protein 2 homolog B is a member of the Dip2 family encoded by the Dip2b gene. Dip2b is widely expressed in neuro-related...
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Prenatal lipopolysaccharide exposure induces anxiety-like behaviour in male mouse offspring and aberrant glial differentiation of embryonic neural stem cells
BackgroundPrenatal infection has been implicated in the development of neuropsychiatric disorders in children. We hypothesised that exposure to...
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MicroRNA Profiling of Self-Renewing Human Neural Stem Cells Reveals Novel Sets of Differentially Expressed microRNAs During Neural Differentiation In Vitro
The involvement of microRNAs (miRNAs) in orchestrating self-renewal and differentiation of stem cells has been revealed in a number of recent...
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Proteomic investigation of neural stem cell to oligodendrocyte precursor cell differentiation reveals phosphorylation-dependent Dclk1 processing
Oligodendrocytes are generated via a two-step mechanism from pluripotent neural stem cells (NSCs): after differentiation of NSCs to oligodendrocyte...
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Salidroside promotes the repair of spinal cord injury by inhibiting astrocyte polarization, promoting neural stem cell proliferation and neuronal differentiation
Spinal cord injury (SCI) remains a formidable challenge, lacking effective treatments. Following SCI, neural stem cells (NSCs) migrate to SCI sites,...
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In vitro effects of H2O2 on neural stem cell differentiation
The development of the CNS is a complex and well-regulated process, where stem cells differentiate into committed cells depending on the stimuli from...
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KLF2 Regulates Neural Differentiation of Dental Pulp-derived Stem Cells by Modulating Autophagy and Mitophagy
BackgroundTransplantation of stem cells for treating neurodegenerative disorders is a promising future therapeutic approach. However, the molecular...
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Investigating neural differentiation of mouse P19 embryonic stem cells in a time-dependent manner by bioinformatic, microscopic and transcriptional analyses
BackgroundAs an available cell line, mouse pluripotent P19 has been widely employed for neuronal differentiation studies. In this research, by...
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Ethanol Causes Cell Death and Neuronal Differentiation Defect During Initial Neurogenesis of the Neural Retina by Disrupting Calcium Signaling in Human Retinal Organoids
Fetal Alcohol Syndrome (FAS) affects a significant proportion, exceeding 90%, of afflicted children, leading to severe ocular aberrations such as...
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Neural is Fundamental: Neural Stemness as the Ground State of Cell Tumorigenicity and Differentiation Potential
Tumorigenic cells are similar to neural stem cells or embryonic neural cells in regulatory networks, tumorigenicity and pluripotent differentiation...
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Differentiation of Speech and Language Functional Systems and Analysis of the Differences in Related Neural Networks
Abstract —This paper explores the problem of differentiation of human speech and language systems. On the basis of contemporary perspectives in speech...
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Treatment with quercetin increases Nrf2 expression and neuronal differentiation of sub ventricular zone derived neural progenitor stem cells in adult rats
BackgroundThe presence of neural precursor stem cells (NPSCs) in some parts of the adult brain and the potency of these types of cells with a...
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An impaired splicing program underlies differentiation defects in hSOD1G93A neural progenitor cells
Amyotrophic lateral sclerosis (ALS) is an adult devastating neurodegenerative disease characterized by the loss of upper and lower motor neurons...
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Linc-NSC affects cell differentiation, apoptosis and proliferation in mouse neural stem cells and embryonic stem cells in vitro and in vivo
BackgroundStem cell therapy is a promising therapeutic strategy. In a previous study, we evaluated tumorigenicity by the stereotactic transplantation...
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Differentiation of Neurons, Astrocytes, Oligodendrocytes and Microglia From Human Induced Pluripotent Stem Cells to Form Neural Tissue-On-Chip: A Neuroinflammation Model to Evaluate the Therapeutic Potential of Extracellular Vesicles Derived from Mesenchymal Stem Cells
Advances in stem cell (SC) technology allow the generation of cellular models that recapitulate the histological, molecular and physiological...
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Electrical stimulation affects the differentiation of transplanted regionally specific human spinal neural progenitor cells (sNPCs) after chronic spinal cord injury
BackgroundThere are currently no effective clinical therapies to ameliorate the loss of function that occurs after spinal cord injury. Electrical...
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Upregulation of Intracellular Zinc Ion Level after Differentiation of the Neural Stem/Progenitor Cells In Vitro with the Changes in Gene Expression of Zinc Transporters
We measured the intracellular zinc ion concentration of murine fetal neural stem/progenitor cells (NSPCs) and that in the differentiated cells. The...
