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Hypothesis on the Endocrine System of the Brain: Evidence for the Regulated Delivery of Neurohormones from the Brain to the Cerebrospinal Fluid and Vice Versa in Neonatal and Prepubertal Periods of Ontogenesis
AbstractThe extensive information accumulated over the past few decades on the important role of cerebrospinal fluid in many physiological processes...
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Encephalopathy of Prematurity: Invisible Cause of Cognitive and Behavioral Disorders
AbstractThe article explores a relatively new concept in pediatrics, neonatology and neurology, encephalopathy of prematurity (EoP). The development...
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Standardisation and future of preclinical echocardiography
Echocardiography is a non-invasive imaging technique providing real-time information to assess the structure and function of the heart. Due to...
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Whole-exome sequencing detected a novel AIFM1 variant in a Han-Chinese family with Cowchock syndrome
Charcot-Marie-Tooth disease(CMT) is a hereditary peripheral neuropathy, characterized by progressive distal hypoesthesia and amyotrophia. CMT is...
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High-risk clones of carbapenem resistant Klebsiella pneumoniae recovered from pediatric patients in Southern Brazil
Carbapenem-resistant Klebsiella pneumoniae (CRKP) exhibit high mortality rates in pediatric patients and usually belong to international high-risk...
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A Brief Review on Erythropoietin and Mesenchymal Stem Cell Therapies for Paediatric Neurological Disorders
Purpose of ReviewPaediatric neurological disorders (PNDs) are neurological conditions in infants resulting from injury to the develo** nervous...
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LOX-1 mediates inflammatory activation of microglial cells through the p38-MAPK/NF-κB pathways under hypoxic-ischemic conditions
BackgroundMicroglial cells play an important role in the immune system in the brain. Activated microglial cells are not only injurious but also...
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Prospects for Gene Therapy of Epilepsy Using Calcium-Acivated Potassium Channel Vectors
AbstractEpilepsy is one of the widespread neurological human diseases, and nearly a third of patients are not completely relieved from epileptic...
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Antibacterial effects of Octenicept, and benzalkonium chloride on Acinetobacter baumannii strains isolated from clinical samples and determination of genetic diversity of isolates by RAPD-PCR method
BackgroundAcinetobacter baumannii ( A. baumannii ) is among the important causes of nosocomial infections. Due to the emergence of antibiotic...
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Cannabis and Parkinson’s Disease
Parkinson’s disease is a slowly progressive, degenerative disorder characterized by resting tremors, stiffness (rigidity), slow and decreased...
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A review of the neural control of micturition in dogs and cats: neuroanatomy, neurophysiology and neuroplasticity
This article discusses the current knowledge on the role of the neurological structures, especially the cerebellum and the hypothalamus, and compares...
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Childhood-related neural genotype–phenotype in ATP1A3 mutations: comprehensive analysis
BackgroundATP1A3 is a gene that encodes the ATPase Na + /K + transporting subunit alpha-3 isoenzyme that is widely expressed in GABAergic neurons....
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Clinical and genetic analyses in syndromic intellectual disability with primary microcephaly reveal biallelic and de novo variants in patients with parental consanguinity
BackgroundSyndromic intellectual disability (ID) with accompanying primary microcephaly is a group of rare neurodevelopmental disorders exhibiting...
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Identification of novel mutations among Iranian NPC1 patients: a bioinformatics approach to predict pathogenic mutations
BackgroundNiemann-Pick disease type C (NPC) is a rare lysosomal neurovisceral storage disease caused by mutations in the NPC 1 (95%) or NPC2 (5%)...
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Severe cardiac and skeletal manifestations in DMD-edited microminipigs: an advanced surrogate for Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is an intractable X-linked muscular dystrophy caused by mutations in the DMD gene. While many animal models have...
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Rare paediatric disorders in Indian healthcare settings with focus on neuromuscular disorders: Diagnostic and management challenges
Rare diseases form the bulk of the financial expenditure of any develo** or developed economy. Among the various rare diseases, paediatric...
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Feasibility of 16S rRNA sequencing for cerebrospinal fluid microbiome analysis in cattle with neurological disorders: a pilot study
Bacterial infection of the central nervous system (CNS) in cattle requires prompt and adequate antimicrobial treatment. The current gold standard for...
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Acceptability of neural stem cell therapy for cerebral palsy: survey of the Australian cerebral palsy community
BackgroundNeural stem cells (NSCs) have the potential to engraft and replace damaged brain tissue, repairing the damaged neonatal brain that causes...
