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MRE11A: a novel negative regulator of human DNA mismatch repair
BackgroundDNA mismatch repair (MMR) is a highly conserved pathway that corrects DNA replication errors, the loss of which is attributed to the...
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Membrane Proteins as a Regulator for Antibiotic Persistence in Gram-Negative Bacteria
Antibiotic treatment failure threatens our ability to control bacterial infections that can cause chronic diseases. Persister bacteria are a...
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GhVIM28, a negative regulator identified from VIM family genes, positively responds to salt stress in cotton
The VIM (belonged to E3 ubiquitin ligase) gene family is crucial for plant growth, development, and stress responses, yet their role in salt stress...
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ANGPTL8 is a negative regulator in pathological cardiac hypertrophy
Pathological cardiac hypertrophy is an independent risk factor for heart failure and is considered a target for the treatment of heart failure....
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The Copper Efflux Regulator (CueR)
The copper efflux regulator (CueR) is a classical member of the MerR family of metalloregulators and is common in gram-negative bacteria. Through its...
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The protein methyltransferase TrSAM inhibits cellulase gene expression by interacting with the negative regulator ACE1 in Trichoderma reesei
Protein methylation is a commonly posttranslational modification of transcriptional regulators to fine-tune protein function, however, whether this...
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AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis
The RAS–BRAF signaling is a major pathway of cell proliferation and their mutations are frequently found in human cancers. Adenylate kinase 2 (AK2),...
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Transcription factor Sp9 is a negative regulator of D1-type MSN development
The striatum is the main input structure of the basal ganglia, receiving information from the cortex and the thalamus and consisting of D1- and D2-...
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Coat protein of rice stripe virus enhances autophagy activity through interaction with cytosolic glyceraldehyde-3-phosphate dehydrogenases, a negative regulator of plant autophagy
Viral infection commonly induces autophagy, leading to antiviral responses or conversely, promoting viral infection or replication. In this study,...
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G2-LIKE CAROTENOID REGULATOR (SlGCR) is a positive regulator of lutein biosynthesis in tomato
Lutein is an oxygen-containing carotenoid synthesized in plant chloroplasts and chromoplasts. It plays an indispensable role in promoting plant...
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A new glucosyltransferase UGT78 from Iris sanguinea is a putative negative regulator in cadmium stress response
Urbanization has resulted in a significant degradation of soil quality, subjecting plants to persistent abiotic stressors such as heavy metal...
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The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation
Activation of RAS is crucial in driving cellular outcomes including proliferation, differentiation, migration and apoptosis via the MAPK pathway....
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Eukaryotic initiation factor 5A hypusine as a negative regulator of adenosine 2B receptor (A2bAR) through interaction with stem loop sequences within the A2bAR 3′-untranslated region
PurposeThe aim of this study was to investigate whether eIF5A hypusine (eIF5A Hyp ) reduces adenosine 2b receptor (A2bAR) gene expression through...
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Crosstalk of TetR-like regulator SACE_4839 and a nitrogen regulator for erythromycin biosynthesis
AbstractTetR family transcriptional regulators (TFRs) are widespread in actinomycetes, which exhibit diverse regulatory modes in antibiotic...
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TRAIL-receptor 2—a novel negative regulator of p53
TNF-related apoptosis-inducing ligand (TRAIL) receptor 2 (TRAIL-R2) can induce apoptosis in cancer cells upon crosslinking by TRAIL. However,...
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Unveiling the repressive mechanism of a PPS-like regulator (PspR) in polyhydroxyalkanoates biosynthesis network
AbstractPoly(3-hydroxybutyrate- co -3-hydroxyvalerate) (PHBV) is a type of polyhydroxyalkanoates (PHA) that exhibits numerous outstanding properties...
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Proteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistance
Epe1 histone demethylase restricts H3K9-methylation-dependent heterochromatin, preventing it from spreading over, and silencing, gene-containing...
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A Mitochondrial Localized Chaperone Regulator OsBAG6 Functions in Saline-Alkaline Stress Tolerance in Rice
B-cell lymphoma 2 (Bcl-2)-associated athanogene (BAG) family genes play prominent roles in regulating plant growth, development, and stress response....
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The stress induced caleosin, RD20/CLO3, acts as a negative regulator of GPA1 in Arabidopsis
Key messageA stress induced calcium-binding protein, RD20/CLO3 interacts with the alpha subunit of the heterotrimeric G-protein complex in...
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ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function
Hepatocarcinogenesis is a multi-step process. However, the regulators of hepatocellular carcinoma (HCC) initiation are understudied. Adult...
