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NANOG controls testicular germ cell tumour stemness through regulation of MIR9-2
BackgroundTesticular germ cell tumours (TGCTs) represent a clinical challenge; they are most prevalent in young individuals and are triggered by...
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c-Fos regulated by TMPO/ERK axis promotes 5-FU resistance via inducing NANOG transcription in colon cancer
Acquired drug resistance is one of the most common limitations for the clinical response of colon cancer to 5-Fluorouracil (5-FU)-based chemotherapy....
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FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway
CDK4/6 inhibitors are routinely recommended agents for the treatment of advanced HR + HER2 − breast cancer. However, their therapeutic effectiveness in...
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Silencing Notch4 promotes tumorigenesis and inhibits metastasis of triple-negative breast cancer via Nanog and Cdc42
Elucidation of individual Notch protein biology in specific cancer is crucial to develop safe, effective, and tumor-selective Notch-targeting...
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Identification of Nanog as a novel inhibitor of Rad51
To develop inhibitors targeting DNA damage repair pathways is important to improve the effectiveness of chemo- and radiotherapy for cancer patients....
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The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate
BackgroundHuman primordial germ cells (hPGCs) initiate from the early post-implantation embryo at week 2–3 and undergo epigenetic reprogramming...
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NANOG prion-like assembly mediates DNA bridging to facilitate chromatin reorganization and activation of pluripotency
Human NANOG expression resets stem cells to ground-state pluripotency. Here we identify the unique features of human NANOG that relate to its...
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Nanog mediated by FAO/ACLY signaling induces cellular dormancy in colorectal cancer cells
Dormant cancer cells drive recurrence and drug resistance, which lead to poor prognosis in colorectal cancer (CRC). The mechanisms that regulate the...
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Characterization of the Nanog gene involved in the gonadal development in pearlscale angelfish (Centropyge vrolikii)
The homeodomain transcription factor Nanog plays a crucial role in the embryonic and gonadal development and the maintenance of embryonic stem cells...
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Trim28 citrullination maintains mouse embryonic stem cell pluripotency via regulating Nanog and Klf4 transcription
Protein citrullination, including histone H1 and H3 citrullination, is important for transcriptional regulation, DNA damage response, and...
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Claudin-6 increases SNAI1, NANOG and SOX2 gene expression in human gastric adenocarcinoma AGS cells
BackgroundGastric cancer is a heterogeneous disease associated to deregulated gastric epithelia tight junction barrier function and di novo ...
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Nanog/NFATc1/Osterix signaling pathway-mediated promotion of bone formation at the tendon–bone interface after ACL reconstruction with De-BMSCs transplantation
BackgroundBone formation plays an important role in early tendon–bone healing after anterior cruciate ligament reconstruction (ACLR)....
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Effect of Nanog overexpression on the metastatic potential of a mouse melanoma cell line B16-BL6
Nanog , a marker and regulator of the undifferentiated state in embryonic stem cells were anticipated to be an effective enhancer of cancer...
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Differential transcriptional regulation of the NANOG gene in chicken primordial germ cells and embryonic stem cells
BackgroundNANOG is a core transcription factor (TF) in embryonic stem cells (ESCs) and primordial germ cells (PGCs). Regulation of the NANOG gene by...
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1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells
Recent studies have demonstrated that acquisition of cancer stem-like properties plays an essential role in promoting epidermal growth factor...
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Alu retrotransposons modulate Nanog expression through dynamic changes in regional chromatin conformation via aryl hydrocarbon receptor
Transcriptional repression of Nanog is an important hallmark of stem cell differentiation. Chromatin modifications have been linked to the epigenetic...
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Nanosecond pulsed electric fields enhance mesenchymal stem cells differentiation via DNMT1-regulated OCT4/NANOG gene expression
BackgroundMultiple strategies have been proposed to promote the differentiation potential of mesenchymal stem cells (MSCs), which is the fundamental...
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RETRACTED ARTICLE: ERK1/2-Nanog signaling pathway enhances CD44(+) cancer stem-like cell phenotypes and epithelial-to-mesenchymal transition in head and neck squamous cell carcinomas
Head and neck squamous cell carcinomas (HNSCCs) harbor a subset of cells that are CD44(+) and present with malignancy and radiotherapy resistance. As...
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Efficient Quantification of Extrinsic Fluctuations via Stochastic Simulations
At the molecular level, all the biological processes are exposed to fluctuations emanating from various sources in and around the cellular system....