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RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis
The T cell population size is stringently controlled before, during, and after immune responses, as improper cell death regulation can result in...
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Esrrb guides naive pluripotent cells through the formative transcriptional programme
During embryonic development, naive pluripotent epiblast cells transit to a formative state. The formative epiblast cells form a polarized...
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c-Jun as a one-way valve at the naive to primed interface
Backgroundc-Jun is a proto-oncogene functioning as a transcription factor to activate gene expression under many physiological and pathological...
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Generation of Human Blastoids from Naive Pluripotent Stem Cells
Under certain culture conditions, naive human pluripotent stem cells can generate human blastocyst-like structures (called human blastoids). Human...
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ID proteins promote the survival and primed-to-naive transition of human embryonic stem cells through TCF3-mediated transcription
Inhibition of DNA binding proteins 1 and 3 (ID1 and ID3) are important downstream targets of BMP signalling that are necessary for embryonic...
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Construction of Human Immune and Naive scFv Phage Display Libraries
Antibody phage display is a widely used in vitro selection technology for the generation of human recombinant antibodies and has yielded thousands of...
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Induction of Human Extraembryonic Mesoderm Cells from Naive Pluripotent Stem Cells
The human extraembryonic mesoderm (EXM) is an important tissue in the postimplantation embryo which is specified before gastrulation in primates but...
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KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2
The pluripotent state of embryonic stem cells (ESCs) is regulated by a sophisticated network of transcription factors. High expression of KLF17 has...
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In vitro naive CD4+ T cell differentiation upon treatment with miR-29b-loaded exosomes from mesenchymal stem cells
BackgroundGene regulation by microRNA (miRNA) is central in T lymphocytes differentiation processes. Here, we investigate miRNA-29b (miR-29b) roles...
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Bilateral Atypical Femur Fractures After Denosumab in a Bisphosphonate Naive Patient: A Case Report
A case report of bilateral atypical femur fractures (AFF) in a bisphosphonate naive patient. A 62-year-old female bisphosphonate naive patient was...
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An fMRI study of scientists with a Ph.D. in physics confronted with naive ideas in science
A central challenge in develo** conceptual understanding in science is overcoming naive ideas that contradict the content of science curricula....
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Study of X Chromosome Activity Status in Human Naive Pluripotent Stem Cells Using RNA-FISH
X chromosome activity is a defining attribute of naive pluripotency, with naive pluripotency being a rare context in which both X chromosomes of...
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Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases
Pluripotent stem cells (PSCs) transition between cell states in vitro, reflecting developmental changes in the early embryo. PSCs can be stabilized...
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Assessing the Ability of Human Dendritic Cells to Stimulate Naive CD4+ and CD8+ T Cells
Dendritic cells orient T cell responses via antigen presentation and provision of polarizing signals. The ability of human dendritic cells to...
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Study of bacterial respiratory infections and antimicrobial susceptibility profile among antibiotics naive outpatients visiting Meru teaching and referral hospital, Meru County, Kenya in 2018
ObjectiveRespiratory tract infections cause significant morbidity and mortality globally and are the most common infectious diseases in humans. This...
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Risk Factor Prediction by Naive Bayes Classifier, Logistic Regression Models, Various Classification and Regression Machine Learning Techniques
Cardiovascular disease (CVD) is globally considered as the leading cause of death. As per the World Health Organization, cardiovascular diseases...
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In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states
Following implantation, the naive pluripotent epiblast of the mouse blastocyst generates a rosette, undergoes lumenogenesis and forms the primed...
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Effect of naive and cancer-educated fibroblasts on colon cancer cell circadian growth rhythm
Opportunistic modification of the tumour microenvironment by cancer cells enhances tumour expansion and consequently eliminates tumour suppressor...
