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Design and Production of Heart Chamber-Specific AAV9 Vectors
Adeno-associated virus serotype 9 (AAV9) is often used in heart research involving gene delivery due to its cardiotropism, high transduction...
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Crosstalk between cardiomyocytes and noncardiomyocytes is essential to prevent cardiomyocyte apoptosis induced by proteasome inhibition
Heart is a multi-cellular organ made up of various cell types interacting with each other. Cardiomyocytes may benefit or suffer from crosstalk with...
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Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation
BackgroundObsessive-compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive actions, that presents the involvement of the...
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The ATPase BRG1/SMARCA4 is a protein interaction platform that recruits BAF subunits and the transcriptional repressor REST/NRSF in neural progenitor cells
The BAF complex (SWI/SNF) is an ATP-dependent chromatin remodeler that adapts the structural organization of the chromatin. Despite a growing...
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Differential responses of sorghum genotypes to drought stress revealed by physio-chemical and transcriptional analysis
Sorghum is an essential food crop for millions of people in the semi-arid regions of the world, where its production is severely limited by drought...
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RNA-Mediated Metabolic Defects in Microsatellite Expansion Diseases
Many incurable neurological and neuromuscular diseases are caused by microsatellite expansions consisted of 3–6 nucleotide repeat units. The expanded...
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Quantitative assessment of near-infrared fluorescent proteins
Recent progress in fluorescent protein development has generated a large diversity of near-infrared fluorescent proteins (NIR FPs), which are rapidly...
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Der Insektenkörper
Insekten sind Arthropoda (Gliederfüßer) mit einem in Kopf (Caput), Brust (Thorax) und Hinterleib (Abdomen) gegliederten Körper (◘ Abb. 2.1). Diese...
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ACTN3 genotype distribution across horses representing different utility types and breeds
In horses, the identification of the genetic background of phenotypic variation, especially with regard to performance characteristics and...
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Iron-regulated small RNA expression as Neisseria gonorrhoeae FA 1090 transitions into stationary phase growth
BackgroundFor most pathogens, iron (Fe) homeostasis is crucial for maintenance within the host and the ability to cause disease. The primary...
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Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage
Leucine-rich repeat kinase 2 ( LRRK2 ), originally identified as a causative genetic factor in Parkinson’s disease, is now associated with a number of...
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RE1 silencing transcription factor (REST) negatively regulates ALL1-fused from chromosome 1q (AF1q) gene transcription
BackgroundALL1-fused from chromosome 1q (AF1q), originally considered as an oncogenic factor, has been implicated in neuronal development; however,...
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Alzheimer’s Disease and ncRNAs
Alzheimer’s disease is a devastating neurodegenerative disorder affecting a significant portion of the world’s rapidly growing aging population. In...
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Identification of REST targets in the Xenopus tropicalis genome
BackgroundA major role of REST (repressor element-1 silencing transcription factor) is to inhibit the expression of neuronal genes in neural stem...
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Epigenetic regulators sculpt the plastic brain
BackgroundEpigenetic regulation is a level of transcriptional regulation that occurs in addition to the genetic programming found in biological...
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Genetic Ablation, Sensitization, and Isolation of Neurons Using Nitroreductase and Tetrodotoxin-Insensitive Channels
Advances in genetic technologies enable the highly selective expression of transgenes in targeted neuronal cell types. Transgene expression can be...
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The quest for mammalian Polycomb response elements: are we there yet?
A long-standing mystery in the field of Polycomb and Trithorax regulation is how these proteins, which are highly conserved between flies and...
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Nucleotide sequence conservation of novel and established cis-regulatory sites within the tyrosine hydroxylase gene promoter
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis and its gene proximal promoter (< 1 kb upstream from the...
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Silencer-delimited transgenesis: NRSE/RE1 sequences promote neural-specific transgene expression in a NRSF/REST-dependent manner
BackgroundWe have investigated a simple strategy for enhancing transgene expression specificity by leveraging genetic silencer elements. The approach...
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The Impact of Oxidative Stress on Dopaminergic Neurotransmission
Dopamine neurotransmission has a demonstrated relevance for a number of neurodegenerative and movement disorders as well as psychiatric conditions...