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Amino acid (acyl carrier protein) ligase-associated biosynthetic gene clusters reveal unexplored biosynthetic potential
This study aimed to evaluate the postulated cellular function of a novel family of amino acid (acyl carrier protein) ligases (AALs) in natural...
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Mining for NRPS and PKS Genes in Actinobacteria Using Whole-Genome Sequencing and Bioinformatic Tools
Antimicrobial resistance of pathogens against known antibiotics is a growing concern. It is a call of emergency to find an effective cure for...
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Biosynthetic Gene Cluster Analysis in Actinobacterial Genus Streptomyces
Secondary metabolites offer a wide variety of biologically active compounds with great potential in medicine, agriculture, or livestock. With the...
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Unveiling biosynthetic potential of an Arctic marine-derived strain Aspergillus sydowii MNP-2
BackgroundA growing number of studies have demonstrated that the polar regions have the potential to be a significant repository of microbial...
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In silico prediction of polyketide biosynthetic gene clusters in the genomes of Hypericum-borne endophytic fungi
BackgroundThe search for new bioactive natural compounds with anticancer activity is still of great importance. Even though their potential for...
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Exploring the biosynthetic gene clusters in Brevibacterium: a comparative genomic analysis of diversity and distribution
Exploring Brevibacterium strains from various ecosystems may lead to the discovery of new antibiotic-producing strains. Brevibacterium sp. H-BE7, a...
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A Bioinformatics Workflow for Investigating Fungal Biosynthetic Gene Clusters
Predicting secondary metabolite biosynthetic gene clusters is a routine analysis performed for each newly sequenced fungal genome. Yet, the...
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Cyanotoxins, biosynthetic gene clusters, and factors modulating cyanotoxin biosynthesis
Cyanobacterial harmful algal blooms (CHABs) are a global environmental concern that encompasses public health issues, water availability, and water...
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Exploring Newer Biosynthetic Gene Clusters in Marine Microbial Prospecting
Marine microbes genetically evolved to survive varying salinity, temperature, pH, and other stress factors by producing different bioactive...
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A widely distributed genus of soil Acidobacteria genomically enriched in biosynthetic gene clusters
Bacteria of the phylum Acidobacteria are one of the most abundant groups across soil ecosystems, yet they are represented by comparatively few...
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Manipulation and epigenetic control of silent biosynthetic pathways in actinobacteria
Most biosynthetic gene clusters (BGCs) of Actinobacteria are either silent or expressed less than the detectable level. The non-genetic approaches...
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Genome sequencing of Colletotrichum gloeosporioides ES026 reveals plausible pathway of HupA
BackgroundColletotrichum gloeosporioides ES026, isolated as an endophytic fungal strain, was found to produce the important medicinal compound...
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Biosynthetic Gene Cluster Analysis in Micromonospora Species Using ANTISMASH: Secondary Metabolite Genome Mining Pipeline
Micromonospora is a prolific producer of antibiotics. Producing more than about 700 antibiotic compounds, Micromonospora has received much attention...
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Mining biosynthetic gene clusters in Paenibacillus genomes to discover novel antibiotics
BackgroundBacterial antimicrobial resistance poses a severe threat to humanity, necessitating the urgent development of new antibiotics. Recent...
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New Report: Genome Mining Untaps the Antibiotics Biosynthetic Gene Cluster of Pseudoalteromonas xiamenensis STKMTI.2 from a Mangrove Soil Sediment
The marine bacterium Pseudoalteromonas xiamenensis STKMTI.2 was isolated from a mangrove soil sediment on Setokok Island, Batam, Indonesia. The...
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Comprehensive analysis of biosynthetic gene clusters in bacteria and discovery of Tumebacillus as a potential producer of natural products
Limited microbial genera such as Streptomyces have served as sources of natural products (NPs), whereas most others have been less investigated. The...
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Heterologous Production and Structure Determination of a New Lanthipeptide Sinosporapeptin Using a Cryptic Gene Cluster in an Actinobacterium Sinosporangium siamense
Lipolanthine is a subclass of lanthipeptide that has the modification of lipid moiety at the N -terminus. A cryptic biosynthetic gene cluster...
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Genome analysis of Cephalotrichum gorgonifer and identification of the biosynthetic pathway for rasfonin, an inhibitor of KRAS dependent cancer
BackgroundFungi are important sources for bioactive compounds that find their applications in many important sectors like in the pharma-, food- or...
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Molecular Biology of Non-ribosomal Peptide (NRP) and Polyketide (PK) Biosynthesis in Cyanobacteria
Secondary metabolites produced by cyanobacteria are numerous and structurally diverse, with a focus on non-ribosomal peptide and polyketide...
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Secondary metabolite gene clusters from the phytopathogenic fungus Gaeumannomyces tritici
The take-all disease is one of the most important maladies in cereals and grasses, being caused by the fungus Gaeumannomyces tritici . Secondary...
