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Design Principles and Benefits of Spatially Explicit Models of Myofilament Function
Spatially explicit models of muscle contraction include fine-scale details about the spatial, kinetic, and/or mechanical properties of the biological...
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Muscle growth and plasticity in teleost fish: the significance of evolutionarily diverse sarcomeric proteins
The skeletal muscle of teleost fish is remarkable in its capacity for indeterminate growth and phenotypic plasticity to function across different...
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Fast and slow skeletal myosin binding protein-C and aging
Aging is associated with skeletal muscle strength decline and cardiac diastolic dysfunction. The structural arrangements of the sarcomeric proteins,...
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Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy
Alterations of serine/threonine phosphorylation of the cardiac proteome are a hallmark of heart failure. However, the contribution of tyrosine...
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Hallmark Features of the Tropomyosin Regulatory Function in Several Variants of Congenital Myopathy
AbstractCongenital myopathies are a group of clinically and genetically heterogeneous diseases, which are united by primary lesions of...
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Simulated microgravity attenuates myogenesis and contractile function of 3D engineered skeletal muscle tissues
While the effects of microgravity on inducing skeletal muscle atrophy have been extensively studied, the impacts of microgravity on myogenesis and...
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Sex-specific cardiovascular remodeling leads to a divergent sex-dependent development of heart failure in aged hypertensive rats
IntroductionThe prevalence of heart failure with preserved ejection fraction (HFpEF) is continuously rising and predominantly affects older women...
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Striated muscle proteins are regulated both by mechanical deformation and by chemical post-translational modification
All cells sense force and build their cytoskeleton to optimize function. How is this achieved? Two major systems are involved. The first is that load...
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Mechanosignaling pathways alter muscle structure and function by post-translational modification of existing sarcomeric proteins to optimize energy usage
A transduced mechanical signal arriving at its destination in muscle alters sarcomeric structure and function. A major question addressed is how...
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In vitro CSC-derived cardiomyocytes exhibit the typical microRNA-mRNA blueprint of endogenous cardiomyocytes
miRNAs modulate cardiomyocyte specification by targeting mRNAs of cell cycle regulators and acting in cardiac muscle lineage gene regulatory loops....
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Epigenetic control of skeletal muscle atrophy
Skeletal muscular atrophy is a complex disease involving a large number of gene expression regulatory networks and various biological processes....
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Cardiac Mechanoperception and Mechanotransduction: Mechanisms of Stretch Sensing in Cardiomyocytes and Implications for Cardiomyopathy
The precise mechanisms, how (1) cardiomyocytes sense information about mechanical load and cellular stretch and strain and how (2) downstream signal...
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Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle
Muscle contraction is driven by the molecular machinery of the sarcomere. As phosphorylation is a critical regulator of muscle function, the...
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Protein Phosphatase Signaling in Cardiac Myocytes
A delicate balance of protein phosphorylation, performed by protein kinases, and dephosphorylation, performed by protein phosphatases, is required...
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Role of the interaction between troponin T and AMP deaminase by zinc bridge in modulating muscle contraction and ammonia production
The N-terminal region of troponin T (TnT) does not bind any protein of the contractile machinery and the role of its hypervariability remains...
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Basic Structure of Skeletal Muscle
Building on the foundational understanding established in the first chapter, Chap. 2 explores the burgeoning...
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Truncation of the N-terminus of cardiac troponin I initiates adaptive remodeling of the myocardial proteosome via phosphorylation of mechano-sensitive signaling pathways
The cardiac isoform of troponin I has a unique N-terminal extension (~ 1–30 amino acids), which contributes to the modulation of cardiac contraction...
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Calcium-Dependent Signaling in Cardiac Myocytes
Calcium (Ca) is a key regulator of cardiac function. Through interactions with various molecular binding partners, Ca controls both acute processes,...
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From amino-acid to disease: the effects of oxidation on actin-myosin interactions in muscle
Actin-myosin interactions form the basis of the force-producing contraction cycle within the sarcomere, serving as the primary mechanism for muscle...
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The Molecular Basis of the Frank-Starling Law of the Heart: A Possible Role for PIEZO1?
The Frank-Starling Law was proposed over 100 years ago, but it remains to be fully explained at the molecular level. The Law states that when the...