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Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure
In striated muscle, the sarcomeric protein myosin-binding protein-C (MyBP-C) is bound to the myosin thick filament and is predicted to stabilize...
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Organisational alteration of cardiac myofilament proteins by hyperglycaemia in mouse embryonic stem cell-derived cardiomyocytes
The exposure of the develo** foetal heart to hyperglycaemia in mothers with diabetes mellitus is a major risk factor for foetal cardiac...
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Fast and slow skeletal myosin binding protein-C and aging
Aging is associated with skeletal muscle strength decline and cardiac diastolic dysfunction. The structural arrangements of the sarcomeric proteins,...
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Protein Phosphatase Signaling in Cardiac Myocytes
A delicate balance of protein phosphorylation, performed by protein kinases, and dephosphorylation, performed by protein phosphatases, is required...
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Alpha and beta myosin isoforms and human atrial and ventricular contraction
Human atrial and ventricular contractions have distinct mechanical characteristics including speed of contraction, volume of blood delivered and the...
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Caenorhabditis elegans ETR-1/CELF has broad effects on the muscle cell transcriptome, including genes that regulate translation and neuroblast migration
Migration of neuroblasts and neurons from their birthplace is central to the formation of neural circuits and networks. ETR-1 is the Caenorhabditis...
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Tropomyosin 3 (TPM3) function in skeletal muscle and in myopathy
The tropomyosin genes ( TPM1-4 ) contribute to the functional diversity of skeletal muscle fibers. Since its discovery in 1988, the TPM3 gene has been...
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A systematic review on active sites and functions of PIM-1 protein
The Proviral Integration of Molony murine leukemia virus (PIM)-1 protein contributes to the solid cancers and hematologic malignancies, cell growth,...
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Beyond Chaperoning: UCS Proteins Emerge as Regulators of Myosin-Mediated Cellular Processes
The UCS (UNC-45/CRO1/She4p) family of proteins has emerged as chaperones specific for the folding, assembly, and function of myosin. UCS proteins...
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Sex-specific cardiovascular remodeling leads to a divergent sex-dependent development of heart failure in aged hypertensive rats
IntroductionThe prevalence of heart failure with preserved ejection fraction (HFpEF) is continuously rising and predominantly affects older women...
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Protein nanomechanics in biological context
How proteins respond to pulling forces, or protein nanomechanics, is a key contributor to the form and function of biological systems. Indeed, the...
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Basic Structure of Skeletal Muscle
Building on the foundational understanding established in the first chapter, Chap. 2 explores the burgeoning...
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Early Divergence of the C-Terminal Variable Region of Troponin T Via a Pair of Mutually Exclusive Alternatively Spliced Exons Followed by a Selective Fixation in Vertebrate Heart
Troponin T (TnT) is the thin filament anchoring subunit of troponin complex and plays an organizer role in the Ca 2+ -regulation of striated muscle...
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Cardiac Mechanoperception and Mechanotransduction: Mechanisms of Stretch Sensing in Cardiomyocytes and Implications for Cardiomyopathy
The precise mechanisms, how (1) cardiomyocytes sense information about mechanical load and cellular stretch and strain and how (2) downstream signal...
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Evolution of the N-Terminal Regulation of Cardiac Troponin I for Heart Function of Tetrapods: Lungfish Presents an Example of the Emergence of Novel Submolecular Structure to Lead the Capacity of Adaptation
Troponin-based Ca 2+ regulation of striated muscle contraction emerged approximately 700 million years ago with largely conserved functions during...
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Motor neurons and endothelial cells additively promote development and fusion of human iPSC-derived skeletal myocytes
BackgroundNeurovascular cells have wide-ranging implications on skeletal muscle biology regulating myogenesis, maturation, and regeneration. Although...
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The Molecular Basis of the Frank-Starling Law of the Heart: A Possible Role for PIEZO1?
The Frank-Starling Law was proposed over 100 years ago, but it remains to be fully explained at the molecular level. The Law states that when the...
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Calcium-Dependent Signaling in Cardiac Myocytes
Calcium (Ca) is a key regulator of cardiac function. Through interactions with various molecular binding partners, Ca controls both acute processes,...
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Role of the interaction between troponin T and AMP deaminase by zinc bridge in modulating muscle contraction and ammonia production
The N-terminal region of troponin T (TnT) does not bind any protein of the contractile machinery and the role of its hypervariability remains...
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Stress Kinase Signaling in Cardiac Myocytes
Stress-response kinases, the mitogen-activated protein kinases (MAPKs), are activated in response to the challenge of a myriad of stressors. c-jun...