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Markers of imminent myocardial infarction
Myocardial infarction is a leading cause of death globally but is notoriously difficult to predict. We aimed to identify biomarkers of an imminent...
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The roles of Th cells in myocardial infarction
Myocardial infarction, commonly known as a heart attack, is a serious condition caused by the abrupt stoppage of blood flow to a part of the heart,...
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Macrophage neogenin deficiency exacerbates myocardial remodeling and inflammation after acute myocardial infarction through JAK1-STAT1 signaling
Immune response plays a crucial role in post-myocardial infarction (MI) myocardial remodeling. Neogenin (Neo1), a multifunctional transmembrane...
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Post translational modifications of connexin 43 in ventricular arrhythmias after myocardial infarction
Ventricular arrhythmias are the leading cause of sudden cardiac death in patients after myocardial infarction (MI). Connexin43 (Cx43) is the most...
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CCR2 imaging in human ST-segment elevation myocardial infarction
Among the diverse populations of myeloid cells that reside within the healthy and diseased heart, C-C chemokine receptor type 2 (CCR2) is...
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Pyroptosis and mitochondrial function participated in miR-654-3p-protected against myocardial infarction
Myocardial infarction (MI) is one of the leading causes of heart failure with highly complicated pathogeneses. miR-654-3p has been recognized as a...
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Cardiac biomarkers and detection methods for myocardial infarction
BackgroundA significant heart attack known as a myocardial infarction (MI) occurs when the blood supply to the heart is suddenly interrupted, harming...
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Serum lipidomics reveals phosphatidylethanolamine and phosphatidylcholine disorders in patients with myocardial infarction and post-myocardial infarction-heart failure
BackgroundMyocardial infarction (MI) and post-MI-heart failure (pMIHF) are a major cause of death worldwide, however, the underlying mechanisms of...
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TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53
Efferocytosis and metabolic reprogramming of macrophages play crucial roles in myocardial infarction (MI) repair. TREM2 has been proven to...
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Anshen Shumai Decoction inhibits post-infarction inflammation and myocardial remodeling through suppression of the p38 MAPK/c-FOS/EGR1 pathway
Anshen Shumai Decoction (ASSMD) is traditionally employed to manage coronary artery disease arrhythmias. Its protective efficacy against myocardial...
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Modeling acute myocardial infarction and cardiac fibrosis using human induced pluripotent stem cell-derived multi-cellular heart organoids
Heart disease involves irreversible myocardial injury that leads to high morbidity and mortality rates. Numerous cell-based cardiac in vitro models...
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Macrophage-driven cardiac inflammation and healing: insights from homeostasis and myocardial infarction
Early and prompt reperfusion therapy has markedly improved the survival rates among patients enduring myocardial infarction (MI). Nonetheless, the...
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MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction
Acute coronary artery blockage leads to acute myocardial infarction (AMI). Cardiomyocytes are terminally differentiated cells that rarely divide....
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M2 macrophage-derived exosomes promote angiogenesis and improve cardiac function after myocardial infarction
BackgroundMyocardial infarction (MI) is a major cause of mortality and morbidity worldwide. The intercellular communication in post-infarction...
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Inflammation in myocardial infarction: roles of mesenchymal stem cells and their secretome
Inflammation plays crucial roles in the regulation of pathophysiological processes involved in injury, repair and remodeling of the infarcted heart;...
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LncRNA CCRR maintains Ca2+ homeostasis against myocardial infarction through the FTO-SERCA2a pathway
Cardiac conduction regulatory RNA (CCRR) has been documented as an antiarrhythmic lncRNA in our earlier investigation. This study aimed to evaluate...
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Advances in the study of exosomes derived from mesenchymal stem cells and cardiac cells for the treatment of myocardial infarction
Acute myocardial infarction has long been the leading cause of death in coronary heart disease, which is characterized by irreversible cardiomyocyte...
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Development of a thick and functional human adipose-derived stem cell tissue sheet for myocardial infarction repair in rat hearts
BackgroundHeart failure (HF) is a major cause of death worldwide. The most effective treatment for HF is heart transplantation, but its use is...
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ATR1 A1166C (rs5186), FII G20210A (rs1799963), FV G1691A (rs6025), FXIII 97G > T (rs11466016) and MTHFR A1298C (rs1801131) polymorphisms and the risk of ST-elevation myocardial infarction in young Mexican individuals
BackgroundPrevious studies had identified genetic variants associated with Myocardial Infarction, but results are inconclusive. We examined the...
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ADSC-derived exosomes attenuate myocardial infarction injury by promoting miR-205-mediated cardiac angiogenesis
BackgroundAcute myocardial infarction is a major health problem and is the leading cause of death worldwide. Myocardial apoptosis induced by...