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Phospholipid Peroxidation in Health and Disease
Phospholipid peroxidation plays a crucial role in modulating the fluidity, integrity, and stability of cellular and organelle membranes. This process... -
Chromatographic purification of small extracellular vesicles using an affinity column for phospholipid membranes
ObjectivesThis study aimed to investigate whether chromatography using an ExoPUA column, an affinity column for phospholipid membranes, could...
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AMPK, a key molecule regulating aging-related myocardial ischemia-reperfusion injury
Aging leads to the threat of more diseases to the biological anatomical structure and the decline of disease resistance, increasing the incidence and...
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ATR1 A1166C (rs5186), FII G20210A (rs1799963), FV G1691A (rs6025), FXIII 97G > T (rs11466016) and MTHFR A1298C (rs1801131) polymorphisms and the risk of ST-elevation myocardial infarction in young Mexican individuals
BackgroundPrevious studies had identified genetic variants associated with Myocardial Infarction, but results are inconclusive. We examined the...
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Crosstalk between macrophages and cardiac cells after myocardial infarction
Cardiovascular diseases, such as myocardial infarction (MI), are a leading cause of death worldwide. Acute MI (AMI) inflicts massive injury to the...
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Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia
IntroductionAcute myocardial ischaemia and the transition from reversible to irreversible myocardial injury are associated with abnormal metabolic...
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Ferroptosis: A Promising Therapeutic Target for Cardiovascular Diseases
Cardiovascular diseases (CVDs) refer to a group of conditions that affect the heart and blood vessels and are a leading cause of death worldwide.... -
Regulation of cardiac ferroptosis in diabetic human heart failure: uncovering molecular pathways and key targets
Diabetes significantly increases the risk of heart failure by inducing myocardial cell death, potentially through ferroptosis—an iron-dependent,...
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Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome
Barth syndrome (BTHS) is a life-threatening genetic disorder with unknown pathogenicity caused by mutations in TAFAZZIN ( TAZ ) that affect remodeling...
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The Role of Arachidonic Acid Metabolism in Myocardial Ischemia–Reperfusion Injury
Patients with myocardial ischemic diseases or who are undergoing one of various heart treatments, such as open heart surgery, coronary artery bypass...
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Pellino1 deficiency reprograms cardiomyocytes energy metabolism in lipopolysaccharide-induced myocardial dysfunction
Pellino1 has been shown to regulate proinflammatory genes by activating the nuclear factor kappa B (NF-κB) and Toll-like receptor (TLR) signaling...
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Research progress on post-translational modification of proteins and cardiovascular diseases
Cardiovascular diseases (CVDs) such as atherosclerosis, myocardial remodeling, myocardial ischemia-reperfusion (I/R) injury, heart failure, and...
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Molecular mechanisms of ferroptosis in cardiovascular disease
Ferroptosis is a newly recognized type of regulated cell death that is characterized by the accumulation of iron and lipid peroxides in cells....
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Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis
The glutathione (GSH) system is considered to be one of the most powerful endogenous antioxidant systems in the cardiovascular system due to its key...
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Comprehensive analysis of transcriptomics and metabolomics to understand chronic ethanol induced murine cardiotoxicity
Alcohol abuse has attracted public attention and long-term alcohol exposure can lead to alcohol-featured non-ischemic dilated cardiomyopathy....
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Noncoding RNAs regulating ferroptosis in cardiovascular diseases: novel roles and therapeutic strategies
The morbidity and mortality rates of cardiovascular diseases (CVDs) are increasing; thus, they impose substantial health and economic burdens...
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Ferroptosis in cardiovascular diseases: role and mechanism
In multicellular organisms, regulatory cell death is a crucial aspect of growth and development. Ferroptosis, which was postulated roughly ten years...
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Discovering a New Metabolic Pathway. Early Work with My Friend, Viswanathan Natarajan
This article summarizes our early work with Viswanathan Natarajan in the 1980s at the University of Minnesota’s Hormel Institute, when he was at the...
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Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease
Mitochondria are highly dynamic organelles that participate in ATP generation and involve calcium homeostasis, oxidative stress response, and...
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Overview of Chemistry and Medicinal Effects of Major Spices
Spices, apart from imparting flavor and aroma to foods, have also been recognized for their health-beneficial attributes since time immemorial,...