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Markers of imminent myocardial infarction
Myocardial infarction is a leading cause of death globally but is notoriously difficult to predict. We aimed to identify biomarkers of an imminent...
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Macrophage-driven cardiac inflammation and healing: insights from homeostasis and myocardial infarction
Early and prompt reperfusion therapy has markedly improved the survival rates among patients enduring myocardial infarction (MI). Nonetheless, the...
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The interplay between T lymphocytes and macrophages in myocardial ischemia/reperfusion injury
Acute myocardial infarction is one of the most important causes of death in the world, causing a huge health and economic burden to the world. It is...
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MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction
Acute coronary artery blockage leads to acute myocardial infarction (AMI). Cardiomyocytes are terminally differentiated cells that rarely divide....
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Coronary lesion complexity in patients with heterozygous familial hypercholesterolemia hospitalized for acute myocardial infarction: data from the RICO survey
BackgroundAlthough patients with familial heterozygous hypercholesterolemia (FH) have a high risk of early myocardial infarction (MI), the coronary...
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Hirudin ameliorates myocardial ischemia–reperfusion injury in a rat model of hemorrhagic shock and resuscitation: roles of NLRP3-signaling pathway
Severe hemorrhage shock and resuscitation (HSR) has been reported to induce myocardial ischemia–reperfusion injury (MIRI), resulting in a poor...
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Development of a thick and functional human adipose-derived stem cell tissue sheet for myocardial infarction repair in rat hearts
BackgroundHeart failure (HF) is a major cause of death worldwide. The most effective treatment for HF is heart transplantation, but its use is...
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Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion
Post-injury dysfunction of humoral immunity accounts for infections and poor outcomes in cardiovascular diseases. Among immunoglobulins (Ig), IgA,...
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Myocardial Infarction with Non-obstructive Coronary Artery Disease: An Overview of Definition, Classification, Diagnostic Workup and Management
Myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) represents 5–10% of patients presenting with acute myocardial...
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Cardioprotective Effect of Empagliflozin in Rats with Isoproterenol-Induced Myocardial Infarction: Evaluation of Lipid Profile, Oxidative Stress, Inflammation, DNA Damage, and Apoptosis
AbstractThe antidiabetic drug empagliflozin is reported to have many cardioprotective effects. However, no studies have investigated the protective...
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Transcription factor Foxp1 stimulates angiogenesis in adult rats after myocardial infarction
Forkhead box protein P1 (FoxP1) is essential for cardiac development and the regulation of neovascularization, but its potential for cardiac...
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Upregulation of Hsp27 via further inhibition of histone H2A ubiquitination confers protection against myocardial ischemia/reperfusion injury by promoting glycolysis and enhancing mitochondrial function
Research suggests that ischemic glycolysis improves myocardial tolerance to anoxia and low-flow ischemia. The rate of glycolysis during ischemia...
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Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia
IntroductionAcute myocardial ischaemia and the transition from reversible to irreversible myocardial injury are associated with abnormal metabolic...
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Pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction
BackgroundProprotein convertase subtilisin/kexin type 9 (Pcsk9) correlated with incidence and prognosis of coronary heart disease. However, it is...
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Imaging Stem Cell-Based Myocardial Vasculoprotection
Treatment of myocardial infarction (MI) focuses on the rapid re-establishment of regional myocardial perfusion following a blockage in one or more of...
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Histone deacetylase HDAC4 participates in the pathological process of myocardial ischemia-reperfusion injury via MEKK1/JNK pathway by binding to miR-206
Histone deacetylases (HDACs) and microRNAs (miRs) have been reported to exert pivotal roles on the pathogenesis of myocardial ischemia-reperfusion...
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Sex-related differences in plasma amino acids of patients with ST-elevation myocardial infarction and glycine as risk marker of acute heart failure with preserved ejection fraction
Nowadays, the problem of preventing acute heart failure (AHF) in patients with ST-elevation myocardial infarction (STEMI) and preserved...
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Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms
Stable atherosclerotic plaques are characterized by a thick, extracellular matrix-rich fibrous cap populated by protective ACTA2 + myofibroblast...
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Ischemia–Reperfusion Injury: Molecular Mechanisms of Pathogenesis and Methods of Their Correction
Abstract —Ischemia–reperfusion is a cascade of complex and interrelated pathological processes underlying many human diseases, including such socially...
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Syndecan-4 is required for early-stage repair responses during zebrafish heart regeneration
BackgroundThe healing process after a myocardial infarction (MI) in humans involves complex events that replace damaged tissue with a fibrotic scar....
