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Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice
Cannabinoids are known to modulate oligodendrogenesis and developmental CNS myelination. However, the cell-autonomous action of these compounds on...
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LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination
A long-standing hypothesis proposes that certain RNA(s) must exhibit structural roles in microtubule assembly. Here, we identify a long noncoding RNA...
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Infants’ cortex undergoes microstructural growth coupled with myelination during development
Development of cortical tissue during infancy is critical for the emergence of typical brain functions in cortex. However, how cortical...
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Evaluation of in vivo lithium chloride effects as a GSK3-β inhibitor on human adipose derived stem cells differentiation into oligodendrocytes and re-myelination in an animal model of multiple sclerosis
BackgroundThe application of neuroprotective agents in combination with stem cells is considered a potential effective treatment for multiple...
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Relevance of biometals during neuronal differentiation and myelination: in vitro and in vivo studies
Biometals are essential during the development of the central nervous system (CNS) since they participate in the organization and regulation of...
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A novel RIP1/RIP3 dual inhibitor promoted OPC survival and myelination in a rat neonatal white matter injury model with hOPC graft
BackgroundThe dual inhibitors of receptor interacting protein kinase-1 and -3 (RIP1 and RIP3) play an important role in cell death processes and...
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Mouse Neural Stem Cell Differentiation and Human Adipose Mesenchymal Stem Cell Transdifferentiation Into Neuron- and Oligodendrocyte-like Cells With Myelination Potential
Stem cell therapy is an interesting approach for neural repair, once it can improve and increase processes, like angiogenesis, neurogenesis, and...
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Identification of Novel Serum Proteins Associated with Myelination and Cholesterol Transport in Neuromyelitis Optica Spectrum Disorders by Mass Spectrometry
Neuromyelitis optica spectrum disorders (NMOSD) is a demyelinating autoimmune disease affecting the central nervous system causing inflammatory...
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The evolution of human altriciality and brain development in comparative context
Human newborns are considered altricial compared with other primates because they are relatively underdeveloped at birth. However, in a broader...
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Superresolution live-cell imaging reveals that the localization of TMEM106B to filopodia in oligodendrocytes is compromised by the hypomyelination-related D252N mutation
Hypomyelination leukodystrophies constitute a group of heritable white matter disorders exhibiting defective myelin development. Initially identified...
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Seipin deficiency-induced lipid dysregulation leads to hypomyelination-associated cognitive deficits via compromising oligodendrocyte precursor cell differentiation
Seipin is one key mediator of lipid metabolism that is highly expressed in adipose tissues as well as in the brain. Lack of Seipin gene, Bscl2 , leads...
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Loss of miR-145 promotes remyelination and functional recovery in a model of chronic central demyelination
Strategies for treating progressive multiple sclerosis (MS) remain limited. Here, we found that miR-145-5p is overabundant uniquely in chronic lesion...
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The emerging role of galectins in (re)myelination and its potential for develo** new approaches to treat multiple sclerosis
Multiple sclerosis (MS) is an inflammatory, demyelinating and neurodegenerative disease of the central nervous system with unknown etiology....
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Transcriptional and metabolic effects of aspartate-glutamate carrier isoform 1 (AGC1) downregulation in mouse oligodendrocyte precursor cells (OPCs)
Aspartate–glutamate carrier isoform 1 (AGC1) is a carrier responsible for the export of mitochondrial aspartate in exchange for cytosolic glutamate...
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Elmo1 function, linked to Rac1 activity, regulates peripheral neuronal numbers and myelination in zebrafish
Peripheral nervous system development involves a tight coordination of neuronal birth and death and a substantial remodelling of the myelinating glia...
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Remyelination in PNS and CNS: current and upcoming cellular and molecular strategies to treat disabling neuropathies
Myelin is a lipid-rich nerve cover that consists of glial cell’s plasmalemma layers and accelerates signal conduction. Axon-myelin contact is a...
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ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation
BackgroundOligodendrocytes have robust regenerative ability and are key players in remyelination during physiological and pathophysiological states....
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TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits
Triggering receptor expressed on myeloid cells-2 (TREM2) has been implicated in susceptibility to neurodegenerative disease. Schwann cells (SCs), the...
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Epigenetic priming of immune/inflammatory pathways activation and abnormal activity of cell cycle pathway in a perinatal model of white matter injury
Prenatal inflammatory insults accompany prematurity and provoke diffuse white matter injury (DWMI), which is associated with increased risk of...
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Spatial and temporal heterogeneity in the lineage progression of fine oligodendrocyte subtypes
BackgroundOligodendrocytes are glial cells that support and insulate axons in the central nervous system through the production of myelin....
