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A role for worm cutl-24 in background- and parent-of-origin-dependent ER stress resistance
BackgroundOrganisms in the wild can acquire disease- and stress-resistance traits that outstrip the programs endogenous to humans. Finding the...
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Design and Self Assembly of Tri-Terpene Peptide Conjugates and Their Interactions with EGFR and EGFR Mutant Receptors: An In Silico and In Vitro Study
In this work, we designed new terpenoid-peptide conjugates to target the epidermal growth factor receptor (EGFR) and its double mutant EGFR...
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Mutant C. elegans mitofusin leads to selective removal of mtDNA heteroplasmic deletions across generations to maintain fitness
BackgroundMitochondrial DNA (mtDNA) is present at high copy numbers in animal cells, and though characterized by a single haplotype in each...
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Health and longevity studies in C. elegans: the “healthy worm database” reveals strengths, weaknesses and gaps of test compound-based studies
Several biogerontology databases exist that focus on genetic or gene expression data linked to health as well as survival, subsequent to compound...
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Possible repair of UV-damaged Spodoptera littoralis nucleopolyhedrovirus DNA via generation of mutant carrying photolyase gene with DNA repair activity
BackgroundBaculoviruses can be inactivated by ultraviolet (UV) light, which limits their application as an efficient biopesticide. In an attempt to...
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Bacterial vitamin B6 is required for post-embryonic development in C. elegans
Nutritional intake influences animal growth, reproductive capacity, and survival of animals. Under nutrition deficiency, animal developmental arrest...
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Aging atlas reveals cell-type-specific effects of pro-longevity strategies
Organismal aging involves functional declines in both somatic and reproductive tissues. Multiple strategies have been discovered to extend lifespan...
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Starvation resistance in the nematode Pristionchus pacificus requires a conserved supplementary nuclear receptor
Nuclear hormone receptors (NHRs) are a deeply-conserved superfamily of metazoan transcription factors, which fine-tune the expression of their...
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Automated recognition and analysis of head thrashes behavior in C. elegans
BackgroundLocomotive behaviors are a rapid evaluation indicator reflecting whether the nervous system of worms is damaged, and has been proved to be...
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Methods for Investigating Cell Division Mechanisms in C. elegans
The nematode Caenorhabditis elegans is a widely used model organism for the study of mitotic and meiotic cell division. These self-fertilizing worms...
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Cpx-signalling facilitates Hms-dependent biofilm formation by Yersinia pseudotuberculosis
Bacteria often reside in sessile communities called biofilms, where they adhere to a variety of surfaces and exist as aggregates in a viscous...
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Genetic Interaction, Epistasis, Modifiers
Biological processes in an organism are interconnected and regulated by a network of genes. Therefore, the genetic dissection of their functional...
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Rapid measurement of ageing by automated monitoring of movement of C. elegans populations
Finding new interventions that slow ageing and maintain human health is a huge challenge of our time. The nematode Caenorhabditis elegans offers a...
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Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog
The extremophile Alvinella pompejana , an annelid worm living on the edge of hydrothermal vents in the Pacific Ocean, is an excellent model system for...
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Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes
Aging is a primary risk factor for neurodegenerative disorders that involve protein aggregation. Because lowering body temperature is one of the most...
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ADARs regulate cuticle collagen expression and promote survival to pathogen infection
BackgroundIn all organisms, the innate immune system defends against pathogens through basal expression of molecules that provide critical barriers...
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Visualizing Phagocytic Cargo In Vivo from Engulfment to Resolution in Caenorhabditis elegans
The nematode Caenorhabditis elegans offers many experimental advantages to study conserved mechanisms of phagocytosis and phagocytic clearance. These...
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Juxtaposing Caenorhabditis elegans-Pathogenic Mould Model with Other Models; How Reliable Is This Nematode Model? A Mini Review
The application of Caenorhabditis elegans as a pathogenic model has spanned decades. Its use for pathogenic mould modeling has been attracting some...
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EAT-2 attenuates C. elegans development via metabolic remodeling in a chemically defined food environment
Dietary intake and nutrient composition regulate animal growth and development; however, the underlying mechanisms remain elusive. Our previous study...
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Modifier pathways in polyglutamine (PolyQ) diseases: from genetic screens to drug targets
Polyglutamine (PolyQ) diseases include a group of inherited neurodegenerative disorders caused by unstable expansions of CAG trinucleotide repeats in...
