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Muscle Progenitor Cell Fusion in the Maintenance of Skeletal Muscle
Skeletal muscle possesses a resident, multipotent stem cell population that is essential for its repair and maintenance throughout life. Here I...
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Insight into muscle stem cell regeneration and mechanobiology
Stem cells possess the unique ability to differentiate into specialized cell types. These specialized cell types can be used for regenerative...
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Regulation of muscle stem cell fate
Skeletal muscle plays a critical role in human health. Muscle stem cells (MuSCs) serve as the major cell type contributing to muscle regeneration by...
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Stem Cell Exhaustion
In a lifetime, several insults occur in human tissues and therefore, the regenerative and repair processes play a crucial role maintaining tissue...
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Extra Eyelid-Derived Muscle Stem Cells
Skeletal muscle stem cells (MuSCs) have been proposed as suitable candidates for cell therapy to muscular disorders since they exhibit a good...
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Mechanical compression creates a quiescent muscle stem cell niche
Tissue stem cell niches are regulated by their mechanical environment, notably the extracellular matrix (ECM). Skeletal muscles consist of bundled...
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Absence of the primary cilia formation gene Talpid3 impairs muscle stem cell function
Skeletal muscle stem cells (MuSC) are crucial for tissue homoeostasis and repair after injury. Following activation, they proliferate to generate...
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Visualizing MyoD Oscillations in Muscle Stem Cells
The bHLH transcription factor MyoD is a master regulator of myogenic differentiation, and its sustained expression in fibroblasts suffices to...
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Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing
The global loss of heterochromatin during ageing has been observed in eukaryotes from yeast to humans, and this has been proposed as one of the...
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Pax7 haploinsufficiency impairs muscle stem cell function in Cre-recombinase mice and underscores the importance of appropriate controls
Ever since its introduction as a genetic tool, the Cre-lox system has been widely used for molecular genetic studies in vivo in the context of health...
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Quantification of Muscle Stem Cell Differentiation Using Live-Cell Imaging and Eccentricity Measures
Culturing primary muscle stem cellsMuscle stem cells ex vivo is a useful method for studying this cell population in controlled environments. Primary...
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Stem Cell Therapy After Neurological Injuries
Axonal degeneration, inflammation, neuronal death, and cytoarchitectural distortion can result from neurological injuries in both the central and...
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Embryonic stem cell-derived mesenchymal stem cells alleviate skeletal muscle injury induced by acute compartment syndrome
BackgroundAcute compartment syndrome (ACS), a well-known complication of musculoskeletal injury, results in muscle necrosis and cell death. Embryonic...
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Application of Single-Cell Sequencing on Stem Cell Research
The variation and heterogeneity within cells are the fundamental features of stem cells. Each tissue has a resident stem cell niche compartmentalized...
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Single-Cell Transcriptomic Analysis of Mononuclear Cell Populations in Skeletal Muscle
Skeletal muscle possesses a remarkable regenerative capacity, mainly relying on a population of undifferentiated and unipotent muscle progenitors,...
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Stem Cell Culture Techniques
Stem cell culture is a crucial cell culture technique that involves diverse disciplines such as modern biotechnology. It is mainly used in the area...
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Co-cultures of Macrophages with Muscle Stem Cells with Fibroadipogenic Precursor Cells from Regenerating Skeletal Muscle
Adult muscle stem cells rebuild myofibers after damage. Although they are highly powerful to implement the adult myogenic program, they need...
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Muscle stem cell adaptations to cellular and environmental stress
BackgroundLifelong regeneration of the skeletal muscle is dependent on a rare population of resident skeletal muscle stem cells, also named...
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Differentiation of Human Fetal Muscle Stem Cells from Induced Pluripotent Stem Cells
Most muscular dystrophies are the result of genetic disorders. There is currently no effective treatment for these progressive diseases except...
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Adult stem cell sources for skeletal and smooth muscle tissue engineering
IntroductionTissue engineering is an innovative field with enormous developments in recent years. These advances are not only in the understanding of...
