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Roles of Skeletal Muscle in Organ Development Prenatal Interdependence among Cells, Tissues, and Organs
Muscle is the only tissue of the four basic types that make the body that can be completely ablated while allowing fetal survival. This book is a...
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Respiratory Mechanics
A rising interest focusing on respiratory mechanics developed around 1950, in particular the link with muscular energetics was quite attractive; this...
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The extracellular matrix mechanics in the vasculature
Mechanical stimuli from the extracellular matrix (ECM) modulate vascular differentiation, morphogenesis and dysfunction of the vasculature. With...
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Basic Structure of Skeletal Muscle
Building on the foundational understanding established in the first chapter, Chap. 2 explores the burgeoning...
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Tools for studying and modulating (cardiac muscle) cell mechanics and mechanosensing across the scales
Cardiomyocytes generate force for the contraction of the heart to pump blood into the lungs and body. At the same time, they are exquisitely tuned to...
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Skeletal Muscle Formation, Regeneration, and Recovery from Injury
In this chapter, we embark on a journey through the remarkable world of skeletal muscle formation, regeneration, and recovery from injury. Skeletal...
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Mechanics of the Left Ventricle in Children Born Prematurely
AbstractAn increase in the birth rate of premature and low birth weight children at the current level of medical development requires the development...
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From amino-acid to disease: the effects of oxidation on actin-myosin interactions in muscle
Actin-myosin interactions form the basis of the force-producing contraction cycle within the sarcomere, serving as the primary mechanism for muscle...
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Cardiac sarcomere mechanics in health and disease
The sarcomere is the fundamental structural and functional unit of striated muscle and is directly responsible for most of its mechanical properties....
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Mechanics of Lung Development
We summarize how skeletal muscle and lung developmental biology fields have been bridged to benefit from mouse genetic engineering technologies and...
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Interplay between mechanics and signalling in regulating cell fate
Mechanical signalling affects multiple biological processes during development and in adult organisms, including cell fate transitions, cell...
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The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction
Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal and heart muscle cells. Dystrophin connects the actin...
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Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis
Skeletal muscle is dynamically controlled by the balance of protein synthesis and degradation. Here we discover an unexpected function for the...
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Mechanical stretch leads to increased caveolin-1 content and mineralization potential in extracellular vesicles from vascular smooth muscle cells
BackgroundHypertension-induced mechanical stress on vascular smooth muscle cells (VSMCs) is a known risk factor for vascular remodeling, including...
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Force and kinetics of fast and slow muscle myosin determined with a synthetic sarcomere–like nanomachine
Myosin II is the muscle molecular motor that works in two bipolar arrays in each thick filament of the striated (skeletal and cardiac) muscle,...
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Insight into muscle stem cell regeneration and mechanobiology
Stem cells possess the unique ability to differentiate into specialized cell types. These specialized cell types can be used for regenerative...
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The influence of biological sex in human skeletal muscle transcriptome during ageing
Sex is a crucial biological variable, and influence of biological sex on the change of gene expression in ageing skeletal muscle has not yet been...
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Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure
In striated muscle, the sarcomeric protein myosin-binding protein-C (MyBP-C) is bound to the myosin thick filament and is predicted to stabilize...
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The 50th anniversary of the European Society for Muscle Research: a journey through half a century of scientific advances
The European Society for Muscle Research (ESMR) started in 1971 as “European Muscle Club” in a joint initiative of Marcus Schaub, Eduard Jenny and...
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Mechanics and functional consequences of nuclear deformations
As the home of cellular genetic information, the nucleus has a critical role in determining cell fate and function in response to various signals and...
