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Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states
BackgroundRibosomal DNA (rDNA) displays substantial inter-individual genetic variation in human and mouse. A systematic analysis of how this...
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Genic constraint against nonsynonymous variation across the mouse genome
BackgroundSelective constraint, the depletion of variation due to negative selection, provides insights into the functional impact of variants and...
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Genetic variation in the Y chromosome and sex-biased DNA methylation in somatic cells in the mouse
Several lines of evidence suggest that the presence of the Y chromosome influences DNA methylation of autosomal loci. To better understand the impact...
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Detecting the effect of genetic diversity on brain composition in an Alzheimer’s disease mouse model
Alzheimer’s disease (AD) is broadly characterized by neurodegeneration, pathology accumulation, and cognitive decline. There is considerable...
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Gut microbial genetic variation modulates host lifespan, sleep, and motor performance
Recent studies have shown that gut microorganisms can modulate host lifespan and activities, including sleep quality and motor performance. However,...
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Analysis of structural variation among inbred mouse strains
Background‘ Long read ’ sequencing methods have been used to identify previously uncharacterized structural variants that cause human genetic...
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Contemporary Body Size Variation of Neotropical Rodents: Environmental and Genetic Effects
Body size is a pivotal ecological and evolutionary trait, as it can significantly impact both survival and reproductive success. To understand how...
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Variation of sexual dimorphism and asymmetry in disease expression of inflammatory arthritis among laboratory mouse models with different genomic backgrounds
Sex difference has shown in the arthritis diseases in human population and animal models. We investigate how the sex and symmetry vary among mouse...
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Phylogeographic relationships, structure, and genetic diversity of the Mexican endemic volcano Harvest Mouse Reithrodontomys chrysopsis (Rodentia, Cricetidae)
Genetic studies in the highlands of Mexico have revealed extensive intraspecific differentiation and highly structured genetic variation in rodents...
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Genetic architecture of protein expression and its regulation in the mouse brain
BackgroundNatural variation in protein expression is common in all organisms and contributes to phenotypic differences among individuals. While...
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Genetic map** and molecular mechanism behind color variation in the Asian vine snake
BackgroundReptiles exhibit a wide variety of skin colors, which serve essential roles in survival and reproduction. However, the molecular basis of...
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Genetic and Morphological Variability of the Ural Field Mouse (Apodemus (Sylvaemus) uralensis, Rodentia) in the North Caucasus
AbstractThe genetic and morphological variability of the southern form of the European chromosomal variety of the Ural field mouse Apodemus ( Sylvaemus...
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Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control
BackgroundGenetic variants can modulate phenotypic outcomes via epigenetic intermediates, for example at methylation quantitative trait loci (mQTL)....
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Every branch in its niche: intraspecific variation in habitat suitability of a widely distributed small mammal, the harvest mouse Micromys minutus
Climate and land use changes re-shape the distribution of species around the world, so understanding biogeographical patterns is key to protect and...
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Allelic to genome wide perspectives of swine genetic variation to litter size and its component traits
Litter size is a complex and sex limited trait that depends on various biological, managemental and environmental factors. Owing to its low...
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CRISMERE Chromosome Engineering in Mouse and Rat
CRISPR/Cas9 technology is a versatile tool for engineering biology that has dramatically transformed our ability to manipulate genomes. In this...
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Population-scale analysis of common and rare genetic variation associated with hearing loss in adults
To better understand the genetics of hearing loss, we performed a genome-wide association meta-analysis with 125,749 cases and 469,497 controls...
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Mouse Models for Hepatic Stellate Cell Activation and Liver Fibrosis Initiation
Liver fibrosis is a severe health problem worldwide with increasing incidence. However, specific drugs for treatment of hepatic fibrosis are...
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Genome-wide screening for genetic variants in polyadenylation signal (PAS) sites in mouse selection lines for fatness and leanness
Alternative polyadenylation (APA) determines mRNA stability, localisation, translation and protein function. Several diseases, including obesity,...
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Deciphering the impact of genetic variation on human polyadenylation using APARENT2
Background3′-end processing by cleavage and polyadenylation is an important and finely tuned regulatory process during mRNA maturation. Numerous...
