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The mitochondrial carrier homolog 2 is involved in down-regulation of influenza A virus replication
BackgroundThe mitochondrial carrier homolog 2 (MTCH2) is a mitochondrial outer membrane protein regulating mitochondrial metabolism and functions in...
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Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans
Animals have internal clocks that generate biological rhythms. In mammals, clock genes such as Period form the circadian clock to generate...
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Mouse Models of Cell Cycle Regulators: New Paradigms
In yeast, a single cyclin-dependent kinase (Cdk) is able to regulate diverse cell cycle transitions (S and M phases) by associating with multiple...
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Enhancer of zeste homolog 2 promotes renal fibrosis after acute kidney injury by inducing epithelial-mesenchymal transition and activation of M2 macrophage polarization
Long-term follow-up data indicates that 1/4 patients with acute kidney injury (AKI) will develop to chronic kidney disease (CKD). Our previous...
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MiR-29a-3p mediates phosphatase and tensin homolog and inhibits osteoarthritis progression
Despite substantial progress in clinical trials of osteoarthritis (OA) gene therapy, the prevalence of OA is still on the rise. MiRNAs have a...
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Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice
Mitochondria in animals are associated with development, as well as physiological and pathological behaviors. Several conserved mitochondrial genes...
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Profiling of testis-specific or testis-predominant genes expressed in mouse male germ cell lines GC-1 and GC-2
BackgroundSpermatogenesis is a tightly organized process that utilizes an intrinsic genetic program composed of germ cell-specific genes. Although...
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A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response
Elevated serum urate (hyperuricemia) promotes crystalline monosodium urate tissue deposits and gout, with associated inflammation and increased...
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The landscape of the long non-coding RNAs in develo** mouse retinas
BackgroundThe long non-coding RNAs (lncRNAs) are critical regulators of diverse biological processes. Nevertheless, a global view of its expression...
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SIRT1 regulates hepatocyte programmed cell death via GSDME - IL18 axis in human and mouse liver transplantation
Sirtuin 1 (SIRT1) is a histone/protein deacetylase in the cellular response to inflammatory, metabolic, and oxidative stressors. We previously...
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scDiffCom: a tool for differential analysis of cell–cell interactions provides a mouse atlas of aging changes in intercellular communication
Dysregulation of intercellular communication is a hallmark of aging. To better quantify and explore changes in intercellular communication, we...
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Knockout mouse models as a resource for the study of rare diseases
Rare diseases (RDs) are a challenge for medicine due to their heterogeneous clinical manifestations and low prevalence. There is a lack of specific...
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Synergistic roles of the phospholipase B homolog Plb1 and the cAMP-dependent protein kinase Pka1 in the hypertonic stress response of Schizosaccharomyces pombe
The phospholipase B homolog Plb1 and the cAMP-dependent protein kinase (PKA) pathway are required by fission yeast, also known as to Schizosaccharomyce...
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Mouse models of spontaneous atrial fibrillation
Atrial fibrillation (AF) is the most common arrhythmia in adults, with a prevalence increasing with age. Current clinical management of AF is focused...
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Evaluation of SOX9-Positive Hepatocytes in Human Liver Specimens and Mature Mouse Hepatocytes
The liver has a remarkable regenerative capacity with different modes of regeneration according to the type and extent of an injury. It has been...
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Comprehensive analysis of N6-methyladenosine-related RNA methylation in the mouse hippocampus after acquired hearing loss
BackgroundThe mechanism underlying cognitive impairment after hearing loss (HL) remains unclear. N6-methyladenosine (m6A) is involved in many...
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Effect of liver receptor homolog-1 on cell apoptosis and steroid hormone secretion on granulosa cells from Hu sheep
The apoptosis of granulosa cells can result in follicular atresia, a key process in follicle selection and development. The related molecular...
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Protein arginine methyltransferase 1 regulates mouse enteroendocrine cell development and homeostasis
BackgroundThe adult intestinal epithelium is a complex, self-renewing tissue composed of specialized cell types with diverse functions. Intestinal...
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Efficient prime editing in mouse brain, liver and heart with dual AAVs
Realizing the promise of prime editing for the study and treatment of genetic disorders requires efficient methods for delivering prime editors (PEs)...
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TMEM30A is essential for hair cell polarity maintenance in postnatal mouse cochlea
BackgroundPhosphatidylserine is translocated to the inner leaflet of the phospholipid bilayer membrane by the flippase function of type IV P-tape...
